iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046493

Ensembl Protein ID

ENSP00000266458.5

UniProt Accession

Q9H0R8; B4E0Y7; Q6FIE6; GBRL1_HUMAN

Genbank Protein ID

AAK55962.1; AAK20399.1; AEZ06294.1; CAB66611.1; BAG64599.1; CAG38511.1; EAW96164.1; AAH09309.1; AAH28315.1

Protein Name

Gamma-aminobutyric acid receptor-associated protein-like 1; Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1

Genbank Nucleotide ID

AF287012; AF087847; JN663881; AL136676; AK303581; CR533480; AC115676; BC009309; BC028315

Gene Name

GABARAPL1; GEC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000139112.10	ENST00000539408.5	ENSP00000443122.1
ENSG00000139112.10	ENST00000266458.9	ENSP00000266458.5
ENSG00000139112.10	ENST00000421801.6	ENSP00000411256.2
ENSG00000139112.10	ENST00000545047.5	ENSP00000441165.1
ENSG00000139112.10	ENST00000541960.5	ENSP00000445709.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/ATG8	ATG8	19533740; 23721406

Classification

Family	E-value	Score	Start	End
ULD/UBL/ATG8	5.10e-53	179.3	14	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 2    rkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgfl 93
           rk+e+ekir+k+pd++Pviveka+k+++p+ldk+kylvPsdltvgq++++irkr++lr+edalf++vnn+++++sat++++ye++++ed+fl
   Q: 14   RKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFL 105
           89****************************************************************************************** PP
   S: 94   yvayaseetfG 104
           yvay++e+++G
   Q: 106  YVAYSDESVYG 116
           **********9 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Protein Sequence
(Fasta)

MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF 60
YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK 117

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCAGCGG AACGCGCAGA GGGCACGGTG CAAGCACGGG ACAGCTCTGC ATTGGCCAAA 60
GGGATCCCAG GAGGCCTGGC CCTCTTTTCT CCTGAGGCTG GATCCCAACC AGCAGGAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-1185--Reference proteome

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0044297--C:cell body
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0032839--C:dendrite cytoplasm
GO:0032590--C:dendrite membrane
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0005622--C:intracellular
GO:0005874--C:microtubule
GO:0048487--F:beta-tubulin binding
GO:0050811--F:GABA receptor binding
GO:0030957--F:Tat protein binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0097352--P:autophagosome maturation
GO:0016236--P:macroautophagy

KEGG

hsa:23710

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002173	Ailuropoda melanoleuca	100.00	7.00e-65	238.00
IUUC-Apl-003994	Anas platyrhynchos	100.00	1.00e-64	237.00
IUUC-Aca-004544	Anolis carolinensis	94.87	4.00e-60	222.00
IUUC-Bta-012584	Bos taurus	100.00	6.00e-65	238.00
IUUC-Cja-019701	Callithrix jacchus	100.00	6.00e-65	238.00
IUUC-Cfa-020883	Canis familiaris	100.00	6.00e-65	238.00
IUUC-Cpo-022522	Cavia porcellus	100.00	6.00e-65	238.00
IUUC-Csa-024162	Chlorocebus sabaeus	100.00	6.00e-65	238.00
IUUC-Cho-025008	Choloepus hoffmanni	95.73	9.00e-62	228.00
IUUC-Dno-030014	Dasypus novemcinctus	100.00	3.00e-65	239.00
IUUC-Eca-033464	Equus caballus	100.00	6.00e-65	238.00
IUUC-Eeu-034826	Erinaceus europaeus	76.92	2.00e-46	176.00
IUUC-Fca-036435	Felis catus	100.00	2.00e-64	237.00
IUUC-Fal-037143	Ficedula albicollis	100.00	1.00e-64	237.00
IUUC-Gga-040919	Gallus gallus	100.00	6.00e-65	238.00
IUUC-Gma-044021	Glycine max	57.39	4.00e-38	149.00
IUUC-Ggo-044931	Gorilla gorilla	100.00	6.00e-65	238.00
IUUC-Itr-048838	Ictidomys tridecemlineatus	100.00	1.00e-64	237.00
IUUC-Laf-054083	Loxodonta africana	100.00	5.00e-65	239.00
IUUC-Mcc-055410	Macaca mulatta	100.00	6.00e-65	238.00
IUUC-Meu-056010	Macropus eugenii	100.00	6.00e-65	238.00
IUUC-Mga-060108	Meleagris gallopavo	100.00	1.00e-64	237.00
IUUC-Mmr-060690	Microcebus murinus	100.00	6.00e-65	238.00
IUUC-Mdo-062279	Monodelphis domestica	100.00	2.00e-65	240.00
IUUC-Mmu-063624	Mus musculus	100.00	6.00e-65	238.00
IUUC-Mpu-066745	Mustela putorius furo	100.00	6.00e-65	238.00
IUUC-Oan-073612	Ornithorhynchus anatinus	98.85	7.00e-47	177.00
IUUC-Ocu-073934	Oryctolagus cuniculus	100.00	5.00e-65	238.00
IUUC-Oga-088360	Otolemur garnettii	100.00	6.00e-65	238.00
IUUC-Oar-089396	Ovis aries	100.00	1.00e-64	238.00
IUUC-Ptr-091136	Pan troglodytes	94.87	1.00e-60	224.00
IUUC-Psi-093055	Pelodiscus sinensis	100.00	6.00e-65	238.00
IUUC-Pfo-096947	Poecilia formosa	61.54	6.00e-32	129.00
IUUC-Pva-103103	Pteropus vampyrus	100.00	6.00e-65	238.00
IUUC-Rno-105347	Rattus norvegicus	100.00	6.00e-65	238.00
IUUC-Sha-106802	Sarcophilus harrisii	100.00	4.00e-65	239.00
IUUC-Ssc-115683	Sus scrofa	99.15	1.00e-64	237.00
IUUC-Tgu-116669	Taeniopygia guttata	100.00	7.00e-65	238.00
IUUC-Tsy-118919	Tarsius syrichta	100.00	6.00e-65	238.00
IUUC-Tca-121335	Theobroma cacao	58.26	7.00e-34	136.00
IUUC-Tbe-128099	Tupaia belangeri	76.92	2.00e-46	176.00
IUUC-Ttr-128712	Tursiops truncatus	100.00	6.00e-65	238.00
IUUC-Vpa-130227	Vicugna pacos	100.00	3.00e-47	179.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence