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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046372
Ensembl Protein ID ENSP00000354878.5
UniProt Accession Q7Z4S6; A8MX28; B0I1R9; B9EGE4; F5H0C3; F5H219; Q2UVF1; Q6UKL9; Q7Z668; Q86WZ5; Q8IVZ8; Q9C0F5; Q9NXU4; Q9Y590; KI21A_HUMAN
Genbank Protein ID AAR04774.1; CAJ45483.1; AAP97680.1; BAG06720.1; AAD42883.1; BAA90916.1; EAW57803.1; AAH41430.1; AAH47572.1; AAI36415.1; BAB21799.2; CAD97863.1
Protein Name Kinesin-like protein KIF21A; Kinesin-like protein KIF2; Renal carcinoma antigen NY-REN-62
Genbank Nucleotide ID AY368076; AM177179; AF450487; AB290166; AC084373; AK000059; CH471111; BC041430; BC047572; BC136414; AB051495; BX537855
Gene Name KIF21A; KIAA1708; KIF2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000139116.18 ENST00000636569.1 ENSP00000490369.1
ENSG00000139116.18 ENST00000361961.7 ENSP00000354851.3
ENSG00000139116.18 ENST00000551264.5 ENSP00000448792.1
ENSG00000139116.18 ENST00000552961.5 ENSP00000447765.1
ENSG00000139116.18 ENST00000544797.6 ENSP00000445606.2
ENSG00000139116.18 ENST00000361418.9 ENSP00000354878.5
ENSG00000139116.18 ENST00000541463.6 ENSP00000438075.2
ENSG00000139116.18 ENST00000547108.5 ENSP00000449698.1
ENSG00000139116.18 ENST00000551066.1 ENSP00000447070.1
ENSG00000139116.18 ENST00000552908.1 ENSP00000449700.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.60e-29 100.6 1345 1379
UBD/Beta-Prp 2.40e-43 150.1 1449 1662
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           gHt  v c++ +d+ll +Gs D t+kvW+l tg  
   Q: 1345 GHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQE 1379
           899*****99767*****************99976 PP
   

   UBD/Beta-Prp
   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sg.dklvsGshdrtirvwdletgqclee..... 131
           + e++++++ ++p+g +++ +++ ++++ wdl+ ++ + +l+gh   v++l++++  sg d +++Gs+d +i+++d+ +g          
   Q: 1449 SGENQINQIALNPTG-TFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQisSGqDLIITGSKDHYIKMFDVTEGALGTVspthn 1537
           56789*********9.999************************************98778*****************9998765467788 PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlngh 221
           ++ +h + +  +++++  + l+sGs D+ ++ Wdl +++ll++   +h+d v  l + ++ + l+sg + g +k+w++ t   v +++gh
   Q: 1538 FEPPHYDGIEALTIQG--DNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGH 1625
           9999999999999999..7799**********************999******************************************* PP
   S: 222  tdnvksvrfspnderlvsgssDgsiriW...dlrsgdll 257
           +++++ + +   ++++ ++++D+++riW   +l+ g++ 
   Q: 1626 DSPINAICVN--STHIFTAADDRTVRIWkarNLQDGQIS 1662
           *****99888..****************99999988876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
 Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
Protein Sequence
(Fasta)
MLGAPDESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 60
QEQIYIQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIVEEE LGIISRAVKH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046372|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGAGCCCG GAGCGCCCTG GCGGGCGTGG AGTCCCCAGC CTGGCCGCTG GGAGGCCGCG 60
TCCCCACCGG AGGGGGCAGG GCGCACTCAC CCGGCCGCCC TGAGGCCGCT GGCGGCCTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046372|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0493--Microtubule
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00225--Kinesin
PF00400--WD40
PRINTS

PR00380--KINESINHEAVY
SMART

SM00129--KISc
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003777--F:microtubule motor activity
GO:0007018--P:microtubule-based movement
KEGG hsa:55605
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001391 Ailuropoda melanoleuca 95.34 0.00e+00 3067.00
IUUC-Apl-003353 Anas platyrhynchos 84.65 0.00e+00 2652.00
IUUC-Aca-004467 Anolis carolinensis 84.20 0.00e+00 2738.00
IUUC-Ame-011430 Astyanax mexicanus 65.00 0.00e+00 1294.00
IUUC-Bta-013485 Bos taurus 95.26 0.00e+00 2964.00
IUUC-Cel-018402 Caenorhabditis elegans 53.49 9.00e-150 525.00
IUUC-Cja-019385 Callithrix jacchus 95.26 0.00e+00 3019.00
IUUC-Cfa-020986 Canis familiaris 96.10 0.00e+00 2997.00
IUUC-Cpo-022297 Cavia porcellus 92.30 0.00e+00 2885.00
IUUC-Csa-023685 Chlorocebus sabaeus 97.73 0.00e+00 3093.00
IUUC-Cho-024531 Choloepus hoffmanni 92.72 0.00e+00 1094.00
IUUC-Cin-025160 Ciona intestinalis 47.66 9.00e-89 321.00
IUUC-Csv-026158 Ciona savignyi 57.81 2.00e-178 620.00
IUUC-Dre-028532 Danio rerio 67.26 0.00e+00 2108.00
IUUC-Dno-029972 Dasypus novemcinctus 91.96 0.00e+00 2797.00
IUUC-Ete-032872 Echinops telfairi 80.64 0.00e+00 1047.00
IUUC-Eca-033518 Equus caballus 96.09 0.00e+00 3034.00
IUUC-Fca-036197 Felis catus 95.75 0.00e+00 3000.00
IUUC-Fal-037534 Ficedula albicollis 84.39 0.00e+00 2675.00
IUUC-Gga-040687 Gallus gallus 83.83 0.00e+00 2623.00
IUUC-Gac-041626 Gasterosteus aculeatus 67.79 0.00e+00 2187.00
IUUC-Ggo-044457 Gorilla gorilla 99.28 0.00e+00 3095.00
IUUC-Lch-049786 Latimeria chalumnae 59.65 0.00e+00 1875.00
IUUC-Loc-052689 Lepisosteus oculatus 74.82 0.00e+00 2372.00
IUUC-Laf-054018 Loxodonta africana 90.08 0.00e+00 2779.00
IUUC-Mcc-055558 Macaca mulatta 98.86 0.00e+00 3121.00
IUUC-Meu-056080 Macropus eugenii 88.79 0.00e+00 997.00
IUUC-Mga-059283 Meleagris gallopavo 83.73 0.00e+00 2603.00
IUUC-Mmr-060773 Microcebus murinus 94.86 0.00e+00 2950.00
IUUC-Mdo-062688 Monodelphis domestica 90.10 0.00e+00 2635.00
IUUC-Mmu-063997 Mus musculus 92.84 0.00e+00 2889.00
IUUC-Mpu-066354 Mustela putorius furo 94.63 0.00e+00 3005.00
IUUC-Mlu-067599 Myotis lucifugus 95.14 0.00e+00 2959.00
IUUC-Nle-069477 Nomascus leucogenys 99.34 0.00e+00 3128.00
IUUC-Opr-070188 Ochotona princeps 81.26 0.00e+00 1804.00
IUUC-Ont-071938 Oreochromis niloticus 69.60 0.00e+00 2189.00
IUUC-Oan-073055 Ornithorhynchus anatinus 88.47 0.00e+00 2655.00
IUUC-Ocu-074302 Oryctolagus cuniculus 92.38 0.00e+00 2959.00
IUUC-Ola-087491 Oryzias latipes 63.95 0.00e+00 1885.00
IUUC-Oga-088799 Otolemur garnettii 94.95 0.00e+00 2709.00
IUUC-Oar-089629 Ovis aries 93.34 0.00e+00 2934.00
IUUC-Pan-092214 Papio anubis 97.13 0.00e+00 3080.00
IUUC-Psi-093757 Pelodiscus sinensis 82.26 0.00e+00 2529.00
IUUC-Pfo-097448 Poecilia formosa 61.83 0.00e+00 1911.00
IUUC-Pab-097984 Pongo abelii 99.22 0.00e+00 3091.00
IUUC-Pca-101061 Procavia capensis 79.32 0.00e+00 1463.00
IUUC-Pva-102306 Pteropus vampyrus 93.85 0.00e+00 2910.00
IUUC-Rno-105354 Rattus norvegicus 91.22 0.00e+00 2811.00
IUUC-Sha-106938 Sarcophilus harrisii 89.38 0.00e+00 1821.00
IUUC-Ssc-115810 Sus scrofa 95.35 0.00e+00 2974.00
IUUC-Tgu-117076 Taeniopygia guttata 82.42 0.00e+00 2543.00
IUUC-Tru-117904 Takifugu rubripes 62.92 0.00e+00 1975.00
IUUC-Tsy-119020 Tarsius syrichta 95.00 0.00e+00 2997.00
IUUC-Tni-120813 Tetraodon nigroviridis 66.88 0.00e+00 2130.00
IUUC-Tbe-127494 Tupaia belangeri 82.54 0.00e+00 1042.00
IUUC-Ttr-128393 Tursiops truncatus 87.93 0.00e+00 2741.00
IUUC-Vpa-130675 Vicugna pacos 82.27 0.00e+00 776.00
IUUC-Xtr-132829 Xenopus tropicalis 78.41 0.00e+00 2537.00
Created Date 25-Jun-2017

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