iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000139842.14	ENST00000375440.8	ENSP00000364589.4
ENSG00000139842.14	ENST00000488558.2	ENSP00000480367.1
ENSG00000139842.14	ENST00000326335.8	ENSP00000322132.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB	SCOP
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/Cullin	Cullin_N_terminal	19276361

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.80e-220	735.5	65	660

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkifayl 90
           kl+eav+++++++s+++++eely+av+nlc++kv+ +lYk+l++++e+++ +q+   +e+s d+  +Lk++n++W+++++q+ ++r+if++l
   Q: 65   KLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVqAQILPFREDSLDSVlFLKKINTCWQDHCRQMIMIRSIFLFL 156
           5899**********************************************99**************************************** PP
   S: 91   drtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefy 180
           drtyv +++++ ++++++l+l+r++i++d  +++++++ +l lie+eR+geavdr+ll+++  +l++L     ++yk+sFE kfle+t+ +y
   Q: 157  DRTYVLQNSTLPSIWDMGLELFRTHIISDkmVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDL-----QVYKDSFELKFLEETNCLY 243
           ****************************************************************9998.....9****************** PP
   S: 181  kaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLlsrvlnglee 271
           +ae ++++qe+ev eYl++v +rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++my+L+srv+ g + 
   Q: 244  AAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILqKGLDHLLDENRVPDLAQMYQLFSRVRGGQQA 335
           **********************************************************9989****************************** PP
   S: 272  llkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.EllAryiDqlLrk 362
           ll++++++ik+ g+a+++++ek+kd   +V++ll++k+k++++++ +F+++++F++ ++++fetf+nk+     +++p El+A+++D++Lr+
   Q: 336  LLQHWSEYIKTFGTAIVINPEKDKD---MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKR-----PNKPaELIAKHVDSKLRA 419
           *************************...*****************************************.....66666************* PP
   S: 363  sskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkee 454
           ++k++t+eele++ldk++++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+d+++S+d++ +Fk++
   Q: 420  GNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQH 511
           ******************************************************************************************** PP
   S: 455  kenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLaf 546
           ++n+++s  ++l+v++L++g+Wpt++ +e v+L++e+ k++e f++fYl khsgRkLqWq+tlg+a lkae+k+gk+e+qVs fQ++vLL+f
   Q: 512  MQNQSDSGPIDLTVNILTMGYWPTYTPME-VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMF 602
           *************************9999.************************************************************** PP
   S: 547  nnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           n+ + +s+ee+k+at+++++eLrrtlqsL+++k++vl k+p++ke+e++d+f++N ef
   Q: 603  NEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEF 660
           *******************************************************998 PP

Organism

Homo sapiens

Functional Description
(View)

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

Protein Sequence
(Fasta)

MADEAPRKGS FSALVGRTNG LTKPAALAAA PAKPGGAGGS KKLVIKNFRD RPRLPDNYTQ 60
DTWRKLHEAV RAVQSSTSIR YNLEELYQAV ENLCSHKVSP MLYKQLRQAC EDHVQAQILP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCATCCCG CATCCTGCTG GGAAACAGCG TCCATCCGAC ACAGCACCGC CCACAGCGGG 60
CCCTCGGCGT GGCCCGCAGG CCCTTCGGAC CGCCTGGGAG CGCGGCCACA CGTGCCAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0007050--P:cell cycle arrest
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0070911--P:global genome nucleotide-excision repair
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0006295--P:nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296--P:nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0006293--P:nucleotide-excision repair, preincision complex stabilization
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0016032--P:viral process

KEGG

hsa:8451

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001592	Ailuropoda melanoleuca	93.20	0.00e+00	1365.00
IUUC-Apl-003269	Anas platyrhynchos	91.97	0.00e+00	1327.00
IUUC-Afl-008567	Aspergillus flavus	39.16	4.00e-138	485.00
IUUC-Afu-008833	Aspergillus fumigatus	38.46	2.00e-132	466.00
IUUC-Ani-009373	Aspergillus nidulans	39.79	1.00e-138	487.00
IUUC-Ang-009622	Aspergillus niger	39.04	9.00e-138	484.00
IUUC-Aor-010241	Aspergillus oryzae	38.76	1.00e-134	473.00
IUUC-Ate-010251	Aspergillus terreus	39.95	1.00e-142	500.00
IUUC-Bgr-012219	Blumeria graminis	36.79	1.00e-116	414.00
IUUC-Bta-012355	Bos taurus	94.17	0.00e+00	1377.00
IUUC-Bci-013744	Botrytis cinerea	39.61	1.00e-130	460.00
IUUC-Cja-019861	Callithrix jacchus	99.30	0.00e+00	1443.00
IUUC-Cfa-021009	Canis familiaris	93.56	0.00e+00	1426.00
IUUC-Cpo-021867	Cavia porcellus	94.86	0.00e+00	1437.00
IUUC-Csa-024139	Chlorocebus sabaeus	99.74	0.00e+00	1479.00
IUUC-Cho-024899	Choloepus hoffmanni	97.02	0.00e+00	1016.00
IUUC-Cin-025727	Ciona intestinalis	62.70	0.00e+00	770.00
IUUC-Csv-026117	Ciona savignyi	53.89	0.00e+00	867.00
IUUC-Cme-027355	Cyanidioschyzon merolae	34.14	3.00e-117	416.00
IUUC-Dno-028879	Dasypus novemcinctus	87.09	0.00e+00	1333.00
IUUC-Dor-030698	Dipodomys ordii	95.13	0.00e+00	1417.00
IUUC-Dme-031652	Drosophila melanogaster	66.90	0.00e+00	954.00
IUUC-Ete-033101	Echinops telfairi	89.33	0.00e+00	1271.00
IUUC-Eca-033696	Equus caballus	93.78	0.00e+00	1372.00
IUUC-Fca-036333	Felis catus	94.37	0.00e+00	1369.00
IUUC-Fal-036995	Ficedula albicollis	91.93	0.00e+00	1345.00
IUUC-Fox-037854	Fusarium oxysporum	39.30	4.00e-126	445.00
IUUC-Fso-038138	Fusarium solani	39.20	4.00e-130	458.00
IUUC-Gga-040358	Gallus gallus	89.18	0.00e+00	1369.00
IUUC-Gma-043960	Glycine max	59.44	0.00e+00	848.00
IUUC-Itr-048182	Ictidomys tridecemlineatus	95.10	0.00e+00	1303.00
IUUC-Lch-050417	Latimeria chalumnae	86.82	0.00e+00	1333.00
IUUC-Laf-054100	Loxodonta africana	94.03	0.00e+00	1368.00
IUUC-Mcc-055168	Macaca mulatta	99.54	0.00e+00	1322.00
IUUC-Meu-056492	Macropus eugenii	73.71	2.00e-171	596.00
IUUC-Mga-059866	Meleagris gallopavo	92.28	0.00e+00	1336.00
IUUC-Mmr-061551	Microcebus murinus	95.26	0.00e+00	1422.00
IUUC-Mdo-062215	Monodelphis domestica	91.37	0.00e+00	1403.00
IUUC-Mmu-063402	Mus musculus	95.13	0.00e+00	1433.00
IUUC-Mpu-066383	Mustela putorius furo	94.11	0.00e+00	1366.00
IUUC-Mlu-067450	Myotis lucifugus	89.66	0.00e+00	1340.00
IUUC-Ncr-068950	Neurospora crassa	36.33	3.00e-120	426.00
IUUC-Nle-069606	Nomascus leucogenys	99.87	0.00e+00	1481.00
IUUC-Opr-070671	Ochotona princeps	85.21	5.00e-118	418.00
IUUC-Oan-073299	Ornithorhynchus anatinus	88.80	0.00e+00	1354.00
IUUC-Ocu-074731	Oryctolagus cuniculus	94.99	0.00e+00	1442.00
IUUC-Oin-079399	Oryza indica	60.47	0.00e+00	724.00
IUUC-Oar-089346	Ovis aries	93.31	0.00e+00	1367.00
IUUC-Ptr-091177	Pan troglodytes	100.00	0.00e+00	1482.00
IUUC-Pan-092191	Papio anubis	99.08	0.00e+00	1469.00
IUUC-Pab-097622	Pongo abelii	99.47	0.00e+00	1473.00
IUUC-Pca-100391	Procavia capensis	84.63	0.00e+00	999.00
IUUC-Pgr-103334	Puccinia graminis	36.48	4.00e-106	379.00
IUUC-Rno-105829	Rattus norvegicus	94.99	0.00e+00	1439.00
IUUC-Sha-106762	Sarcophilus harrisii	93.61	0.00e+00	1330.00
IUUC-Sre-114943	Sporisorium reilianum	38.75	5.00e-132	465.00
IUUC-Ssc-116133	Sus scrofa	92.51	0.00e+00	1383.00
IUUC-Tgu-116961	Taeniopygia guttata	91.54	0.00e+00	1341.00
IUUC-Tre-121907	Trichoderma reesei	39.53	4.00e-132	465.00
IUUC-Tvi-122568	Trichoderma virens	39.00	1.00e-131	463.00
IUUC-Tme-127162	Tuber melanosporum	40.99	3.00e-140	493.00
IUUC-Ttr-128326	Tursiops truncatus	88.94	0.00e+00	1181.00
IUUC-Uma-129531	Ustilago maydis	39.71	4.00e-114	405.00
IUUC-Vvi-131133	Vitis vinifera	58.91	0.00e+00	855.00
IUUC-Xtr-132761	Xenopus tropicalis	81.94	0.00e+00	1256.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence