iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003358

Ensembl Protein ID

ENSAPLP00000002850.1

UniProt Accession

U3I6H9; U3I6H9_ANAPL

Genbank Protein ID

ENSAPLP00000002850

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADON01126906

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000003323.1	ENSAPLT00000003444.1	ENSAPLP00000002850.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-100	336.8	137	488
UBD/ZnF/ZnF_UBP	1.70e-25	88.7	9	82

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 137  TGLRNLGNTCFMNAILQSLSNIQQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 225
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    +   ++ +++   +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 226  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSVILQE-NSSLTASSKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 313
           *****************************663333333333333.3334445788999999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 314  PFLDLSLDIPSQFRNKRTknqengpmcTLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 400
           **********66654444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+lf
   Q: 401  KVDTYVEFPLRgLDMKCYLLEPENSGPESCLYDLAAVVVHHGsGVGSGHYTAYAAH-EGRWFHFNDSTVTLTDEETVVK---AKAYILF 485
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 486  YVE 488
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 5    vcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           vc++++++W+cLtc+sv+CGRyv+gHa+kHye++q p+                ++++s++s+ycY+cdd+v++
   Q: 9    VCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPMtnhkktekqekvqhtvCMDCSSYSTYCYRCDDFVVN 82
           7***********************************************************************85 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

VTFFMSFVVC RSNKSPWVCL TCSSVHCGRY VNGHAKKHYE DAQIPMTNHK KTEKQEKVQH 60
TVCMDCSSYS TYCYRCDDFV VNDTKLGLVQ KVREHLQNLE NSAFTSDRHR KRKLLENSSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACTTTTT TCATGTCTTT TGTAGTGTGC CGGTCAAATA AAAGTCCATG GGTCTGTCTG 60
ACGTGCTCGA GTGTCCATTG TGGAAGGTGG GTACTAAGTA TTAGTTTGAA AAACGTTTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	95.51	0.00e+00	882.00
IUUC-Aca-004454	Anolis carolinensis	93.57	0.00e+00	816.00
IUUC-Ame-011544	Astyanax mexicanus	77.41	0.00e+00	691.00
IUUC-Bta-012738	Bos taurus	95.52	0.00e+00	866.00
IUUC-Cel-018186	Caenorhabditis elegans	37.85	1.00e-55	210.00
IUUC-Cja-018893	Callithrix jacchus	95.71	0.00e+00	876.00
IUUC-Cfa-020607	Canis familiaris	95.71	0.00e+00	865.00
IUUC-Cpo-021828	Cavia porcellus	94.08	0.00e+00	847.00
IUUC-Csa-023884	Chlorocebus sabaeus	96.47	0.00e+00	770.00
IUUC-Cho-024863	Choloepus hoffmanni	85.51	0.00e+00	741.00
IUUC-Dre-028452	Danio rerio	74.49	0.00e+00	705.00
IUUC-Dno-029531	Dasypus novemcinctus	94.34	0.00e+00	865.00
IUUC-Dor-030913	Dipodomys ordii	86.53	9.00e-175	605.00
IUUC-Ete-032611	Echinops telfairi	90.00	0.00e+00	811.00
IUUC-Eca-033622	Equus caballus	95.33	0.00e+00	867.00
IUUC-Eeu-035268	Erinaceus europaeus	91.00	0.00e+00	795.00
IUUC-Fca-035801	Felis catus	94.55	0.00e+00	899.00
IUUC-Fal-036749	Ficedula albicollis	96.75	0.00e+00	872.00
IUUC-Gmo-039598	Gadus morhua	77.96	0.00e+00	728.00
IUUC-Gga-040883	Gallus gallus	99.40	0.00e+00	903.00
IUUC-Gac-042235	Gasterosteus aculeatus	77.60	0.00e+00	706.00
IUUC-Ggo-044767	Gorilla gorilla	90.02	0.00e+00	828.00
IUUC-Hsa-046581	Homo sapiens	95.71	0.00e+00	900.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	95.92	0.00e+00	866.00
IUUC-Lch-049732	Latimeria chalumnae	91.43	0.00e+00	863.00
IUUC-Loc-052371	Lepisosteus oculatus	89.59	0.00e+00	846.00
IUUC-Laf-054565	Loxodonta africana	95.31	0.00e+00	864.00
IUUC-Mcc-055522	Macaca mulatta	95.92	0.00e+00	903.00
IUUC-Meu-056754	Macropus eugenii	87.16	3.00e-161	561.00
IUUC-Mga-060095	Meleagris gallopavo	99.11	0.00e+00	662.00
IUUC-Mmr-060839	Microcebus murinus	95.92	0.00e+00	865.00
IUUC-Mdo-062339	Monodelphis domestica	97.70	0.00e+00	763.00
IUUC-Mmu-063638	Mus musculus	94.29	0.00e+00	834.00
IUUC-Mpu-066647	Mustela putorius furo	96.32	0.00e+00	755.00
IUUC-Mlu-067921	Myotis lucifugus	93.70	0.00e+00	880.00
IUUC-Nle-069752	Nomascus leucogenys	96.12	0.00e+00	904.00
IUUC-Opr-070636	Ochotona princeps	84.66	0.00e+00	720.00
IUUC-Ont-071638	Oreochromis niloticus	76.84	0.00e+00	703.00
IUUC-Oan-073417	Ornithorhynchus anatinus	91.22	0.00e+00	840.00
IUUC-Ocu-074620	Oryctolagus cuniculus	94.08	0.00e+00	853.00
IUUC-Ola-087281	Oryzias latipes	79.03	0.00e+00	632.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.33	5.00e-49	187.00
IUUC-Oga-088448	Otolemur garnettii	94.90	0.00e+00	891.00
IUUC-Oar-090132	Ovis aries	95.71	0.00e+00	865.00
IUUC-Ptr-090696	Pan troglodytes	94.94	0.00e+00	902.00
IUUC-Pan-092124	Papio anubis	95.71	0.00e+00	898.00
IUUC-Psi-093801	Pelodiscus sinensis	97.70	0.00e+00	761.00
IUUC-Pma-094472	Petromyzon marinus	73.68	4.00e-96	343.00
IUUC-Pfo-096330	Poecilia formosa	79.23	0.00e+00	736.00
IUUC-Pab-098191	Pongo abelii	95.92	0.00e+00	903.00
IUUC-Pca-100341	Procavia capensis	93.87	0.00e+00	654.00
IUUC-Pva-103177	Pteropus vampyrus	95.10	0.00e+00	852.00
IUUC-Rno-105048	Rattus norvegicus	92.89	0.00e+00	818.00
IUUC-Sha-107429	Sarcophilus harrisii	97.56	0.00e+00	881.00
IUUC-Sar-113024	Sorex araneus	93.60	0.00e+00	806.00
IUUC-Ssc-115749	Sus scrofa	93.59	2.00e-149	520.00
IUUC-Tgu-117277	Taeniopygia guttata	97.35	0.00e+00	908.00
IUUC-Tru-117844	Takifugu rubripes	78.41	0.00e+00	730.00
IUUC-Tsy-119456	Tarsius syrichta	92.84	0.00e+00	856.00
IUUC-Tni-120251	Tetraodon nigroviridis	75.41	0.00e+00	749.00
IUUC-Tbe-127423	Tupaia belangeri	89.18	0.00e+00	782.00
IUUC-Ttr-128401	Tursiops truncatus	89.16	0.00e+00	784.00
IUUC-Vpa-130549	Vicugna pacos	84.73	2.00e-161	560.00
IUUC-Xtr-131892	Xenopus tropicalis	83.17	0.00e+00	751.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence