iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000140854.12	ENST00000379661.7	ENSP00000368982.3
ENSG00000140854.12	ENST00000566726.5	ENSP00000455270.1
ENSG00000140854.12	ENST00000569627.1	ENSP00000457046.1
ENSG00000140854.12	ENST00000563462.1	ENSP00000457334.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.30e-45	151.0	145	180
UBD/Beta-Prp	1.20e-59	203.7	15	258

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl gh++
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKA 106
           67788888999888899*************************************************************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls 187
           +++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht++v+ ++
   Q: 107  NICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTGPVNVVE 196
           **********************************9.9********************************************9.********* PP
   S: 188  fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           f++n   l+sgs d+t+++wdl++ ++v   +g   +v+sv f p++  l+sg +D s+r++ 
   Q: 197  FHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYG 258
           *****************************************************766.556543 PP

Organism

Homo sapiens

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCTCTGAG CCGGAGGTTT TGTTGTGAGG GTCGGTTGTC AAGCAGCGGC CAATCAAGGC 60
AGGGGATGGA GGCAAGTGGG GGTCGCGCCT GGAGCGGAGC CTCGGCCTCC GGAGCCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0451--Lissencephaly
KW-0493--Microtubule
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030426--C:growth cone
GO:0008352--C:katanin complex
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0030496--C:midbody
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0046982--F:protein heterodimerization activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007067--P:mitotic nuclear division
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0010942--P:positive regulation of cell death
GO:0031117--P:positive regulation of microtubule depolymerization
GO:0010976--P:positive regulation of neuron projection development
GO:0006605--P:protein targeting

KEGG

hsa:10300

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	46.30	2.00e-86	315.00
IUUC-Aml-002187	Ailuropoda melanoleuca	89.66	0.00e+00	1111.00
IUUC-Atr-002899	Amborella trichopoda	42.95	9.00e-103	368.00
IUUC-Apl-003305	Anas platyrhynchos	77.70	0.00e+00	1024.00
IUUC-Aca-004635	Anolis carolinensis	80.34	0.00e+00	971.00
IUUC-Aly-005711	Arabidopsis lyrata	51.50	1.00e-101	364.00
IUUC-Ath-007606	Arabidopsis thaliana	51.50	2.00e-101	363.00
IUUC-Ame-010870	Astyanax mexicanus	56.97	3.00e-98	352.00
IUUC-Bta-012527	Bos taurus	95.63	0.00e+00	1202.00
IUUC-Bdi-014652	Brachypodium distachyon	50.61	4.00e-104	373.00
IUUC-Bol-015242	Brassica oleracea	50.50	7.00e-100	358.00
IUUC-Bra-017390	Brassica rapa	50.83	2.00e-100	360.00
IUUC-Cja-019706	Callithrix jacchus	97.41	0.00e+00	1128.00
IUUC-Cfa-020139	Canis familiaris	81.12	0.00e+00	776.00
IUUC-Cpo-021710	Cavia porcellus	95.11	0.00e+00	1175.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.47	6.00e-69	255.00
IUUC-Csa-023546	Chlorocebus sabaeus	99.24	0.00e+00	1090.00
IUUC-Cin-025156	Ciona intestinalis	42.11	2.00e-157	549.00
IUUC-Csv-025962	Ciona savignyi	49.66	1.00e-89	323.00
IUUC-Dre-028215	Danio rerio	62.29	0.00e+00	860.00
IUUC-Dno-029314	Dasypus novemcinctus	94.81	0.00e+00	1129.00
IUUC-Dor-030482	Dipodomys ordii	96.03	0.00e+00	1225.00
IUUC-Dme-032188	Drosophila melanogaster	39.81	1.00e-59	224.00
IUUC-Eca-034143	Equus caballus	95.73	0.00e+00	1199.00
IUUC-Fca-035924	Felis catus	96.79	0.00e+00	1174.00
IUUC-Fal-037387	Ficedula albicollis	79.21	0.00e+00	1005.00
IUUC-Gmo-038692	Gadus morhua	65.28	8.00e-155	540.00
IUUC-Gga-040597	Gallus gallus	79.18	0.00e+00	1053.00
IUUC-Gac-042004	Gasterosteus aculeatus	61.99	0.00e+00	834.00
IUUC-Gma-044134	Glycine max	33.38	5.00e-108	385.00
IUUC-Ggo-044761	Gorilla gorilla	99.69	0.00e+00	1134.00
IUUC-Hvu-047649	Hordeum vulgare	51.06	2.00e-104	373.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	95.11	0.00e+00	1156.00
IUUC-Lch-049674	Latimeria chalumnae	68.14	0.00e+00	931.00
IUUC-Lpe-051554	Leersia perrieri	49.58	5.00e-107	382.00
IUUC-Loc-052623	Lepisosteus oculatus	66.81	0.00e+00	906.00
IUUC-Laf-054587	Loxodonta africana	96.50	0.00e+00	1181.00
IUUC-Mcc-055851	Macaca mulatta	99.54	0.00e+00	1134.00
IUUC-Meu-056704	Macropus eugenii	90.27	0.00e+00	1193.00
IUUC-Mtr-058053	Medicago truncatula	52.49	1.00e-104	374.00
IUUC-Mga-059608	Meleagris gallopavo	78.66	0.00e+00	1040.00
IUUC-Mmr-061154	Microcebus murinus	94.66	0.00e+00	1131.00
IUUC-Mdo-062365	Monodelphis domestica	86.52	0.00e+00	1123.00
IUUC-Mmu-063754	Mus musculus	95.14	0.00e+00	1160.00
IUUC-Mac-064667	Musa acuminata	52.38	7.00e-101	360.00
IUUC-Mpu-066245	Mustela putorius furo	96.18	0.00e+00	1128.00
IUUC-Mlu-067692	Myotis lucifugus	95.99	0.00e+00	1157.00
IUUC-Nle-070051	Nomascus leucogenys	96.34	0.00e+00	1112.00
IUUC-Opr-070855	Ochotona princeps	95.57	0.00e+00	1176.00
IUUC-Ont-071883	Oreochromis niloticus	59.26	0.00e+00	830.00
IUUC-Oan-073293	Ornithorhynchus anatinus	89.92	0.00e+00	1041.00
IUUC-Ocu-074644	Oryctolagus cuniculus	96.64	0.00e+00	1194.00
IUUC-Oba-075448	Oryza barthii	54.85	1.00e-106	381.00
IUUC-Obr-076385	Oryza brachyantha	50.76	5.00e-106	379.00
IUUC-Ogl-077427	Oryza glaberrima	51.66	2.00e-107	383.00
IUUC-Ogu-079022	Oryza glumaepatula	48.88	4.00e-98	352.00
IUUC-Oin-079811	Oryza indica	49.56	3.00e-104	373.00
IUUC-Olo-080245	Oryza longistaminata	49.56	2.00e-104	373.00
IUUC-Ome-081239	Oryza meridionalis	51.08	8.00e-104	371.00
IUUC-Oni-082640	Oryza nivara	54.85	1.00e-106	381.00
IUUC-Opu-083748	Oryza punctata	51.52	4.00e-107	382.00
IUUC-Oru-084609	Oryza rufipogon	54.85	1.00e-106	381.00
IUUC-Osa-086267	Oryza sativa	48.88	4.00e-98	353.00
IUUC-Ola-087483	Oryzias latipes	56.56	0.00e+00	640.00
IUUC-Oga-087964	Otolemur garnettii	95.73	0.00e+00	1197.00
IUUC-Oar-089483	Ovis aries	94.12	0.00e+00	1155.00
IUUC-Ptr-091387	Pan troglodytes	99.85	0.00e+00	1170.00
IUUC-Pan-092623	Papio anubis	99.54	0.00e+00	1134.00
IUUC-Psi-093830	Pelodiscus sinensis	81.69	0.00e+00	1058.00
IUUC-Pma-094135	Petromyzon marinus	46.00	2.00e-40	159.00
IUUC-Ppa-095379	Physcomitrella patens	54.79	6.00e-98	352.00
IUUC-Pfo-096755	Poecilia formosa	58.14	0.00e+00	807.00
IUUC-Pab-097564	Pongo abelii	98.28	0.00e+00	999.00
IUUC-Pop-099149	Populus trichocarpa	52.49	3.00e-104	373.00
IUUC-Pca-100357	Procavia capensis	99.52	3.00e-126	445.00
IUUC-Ppe-101237	Prunus persica	52.49	4.00e-104	372.00
IUUC-Pva-102397	Pteropus vampyrus	92.06	0.00e+00	1092.00
IUUC-Rno-105349	Rattus norvegicus	95.11	0.00e+00	1204.00
IUUC-Smo-109409	Selaginella moellendorffii	54.27	9.00e-102	364.00
IUUC-Sit-110360	Setaria italica	51.52	6.00e-107	382.00
IUUC-Sly-111307	Solanum lycopersicum	52.82	2.00e-99	357.00
IUUC-Stu-112462	Solanum tuberosum	52.40	8.00e-96	344.00
IUUC-Sar-112953	Sorex araneus	82.02	5.00e-109	388.00
IUUC-Sbi-114389	Sorghum bicolor	46.98	1.00e-94	340.00
IUUC-Ssc-115949	Sus scrofa	93.86	0.00e+00	886.00
IUUC-Tgu-117461	Taeniopygia guttata	78.38	0.00e+00	1033.00
IUUC-Tru-117865	Takifugu rubripes	58.29	0.00e+00	792.00
IUUC-Tsy-119036	Tarsius syrichta	84.08	3.00e-87	315.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.88	0.00e+00	783.00
IUUC-Tca-121185	Theobroma cacao	51.50	3.00e-101	363.00
IUUC-Tae-125263	Triticum aestivum	51.36	1.00e-104	374.00
IUUC-Tur-126181	Triticum urartu	47.96	1.00e-94	341.00
IUUC-Tbe-127518	Tupaia belangeri	81.88	0.00e+00	646.00
IUUC-Ttr-128172	Tursiops truncatus	96.34	0.00e+00	1157.00
IUUC-Vvi-131489	Vitis vinifera	53.16	1.00e-104	374.00
IUUC-Xtr-132915	Xenopus tropicalis	73.17	0.00e+00	971.00
IUUC-Xma-134133	Xiphophorus maculatus	57.85	0.00e+00	796.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence