iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071883

Ensembl Protein ID

ENSONIP00000004180.1

UniProt Accession

I3J5P0; I3J5P0_ORENI

Genbank Protein ID

ENSONIP00000004180

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

AERX01000472

Gene Name

katnb1; KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000003323.1	ENSONIT00000004181.1	ENSONIP00000004180.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-44	148.3	145	180
UBD/Beta-Prp	6.50e-60	203.2	16	280

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt  v++laf +d + l+s+sdD+t+k+WDl +g+
   Q: 145  GHTQAVRSLAFsPDgKWLASASDDCTVKLWDLAQGK 180
           8***********999*****************9987 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           +++h s i+c++  + +++llatg++d ++ +w v++ +++ sl gh+++v ++ f+ +++  v gs+ + i+vwdl++ k+++tl gh
   Q: 16   FEAHFSSISCLALgKSSGRLLATGGEDCRVNIWAVSKANCIMSLTGHKNPVECIHFNVSEEQVVAGSQSGSIRVWDLEAAKILRTLMGH 104
           67888999999999*************************************************************************** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdlet.gqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           +++++sl f+p gd+l+s s d  i++wd++  g++++   +gh+++v++++++pdg+ l+s+s+D tv+lWdl++gk ++++++ ht 
   Q: 105  KANITSLGFHPFGDFLASSSMDTNIKLWDVRRkGYVFR--YKGHTQAVRSLAFSPDGKWLASASDDCTVKLWDLAQGKTITEFKS-HTA 190
           ******************************86156665..********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisv 270
           +v+ ++f++n   l+sgs d+t+klwdl++ +++ +l+g t++v+++ fsp++  l+sg+ D s+r++  + + +  +++    +v+ v
   Q: 191  PVNIIQFHPNEYLLASGSSDRTIKLWDLEKFTMIGSLEGDTTPVRCICFSPDGSCLYSGATD-SLRVFGWEPDRCFDAVSVGWGKVSDV 278
           ***********************************************************977.56666668999998888888777777 PP
   S: 271  av 272
           a 
   Q: 279  AI 280
           76 PP

Organism

Oreochromis niloticus

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Protein Sequence
(Fasta)

MAASSTTKIA WRLQEFEAHF SSISCLALGK SSGRLLATGG EDCRVNIWAV SKANCIMSLT 60
GHKNPVECIH FNVSEEQVVA GSQSGSIRVW DLEAAKILRT LMGHKANITS LGFHPFGDFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCCT CCAGCACCAC CAAGATCGCA TGGCGCCTTC GTGAGTATTA AAGTTACTCA 60
GACAGTCATC ACACCCTTCC TGTCCAGCAG CCCAGCCTGA CCTGAATTTG TCCCTCCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0030901--P:midbrain development
GO:0007067--P:mitotic nuclear division

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	45.45	3.00e-78	287.00
IUUC-Aml-002187	Ailuropoda melanoleuca	58.06	0.00e+00	741.00
IUUC-Atr-002899	Amborella trichopoda	46.96	9.00e-97	348.00
IUUC-Apl-003305	Anas platyrhynchos	60.09	0.00e+00	795.00
IUUC-Aca-004635	Anolis carolinensis	59.20	0.00e+00	750.00
IUUC-Aly-005711	Arabidopsis lyrata	51.50	5.00e-100	358.00
IUUC-Ath-007606	Arabidopsis thaliana	51.50	5.00e-100	359.00
IUUC-Ame-010870	Astyanax mexicanus	59.58	3.00e-108	385.00
IUUC-Bta-012527	Bos taurus	59.26	0.00e+00	776.00
IUUC-Bdi-014652	Brachypodium distachyon	50.83	2.00e-98	353.00
IUUC-Bol-015242	Brassica oleracea	50.48	2.00e-99	357.00
IUUC-Bra-017390	Brassica rapa	50.49	3.00e-99	356.00
IUUC-Cja-019706	Callithrix jacchus	66.75	4.00e-148	518.00
IUUC-Cfa-020139	Canis familiaris	49.75	4.00e-137	481.00
IUUC-Cpo-021710	Cavia porcellus	59.41	0.00e+00	778.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	40.33	4.00e-68	253.00
IUUC-Csa-023546	Chlorocebus sabaeus	64.76	8.00e-141	494.00
IUUC-Cin-025156	Ciona intestinalis	44.70	1.00e-82	300.00
IUUC-Csv-025962	Ciona savignyi	46.71	2.00e-79	288.00
IUUC-Dre-028215	Danio rerio	66.76	0.00e+00	897.00
IUUC-Dno-029314	Dasypus novemcinctus	66.50	2.00e-152	532.00
IUUC-Dor-030482	Dipodomys ordii	58.98	0.00e+00	790.00
IUUC-Dme-032188	Drosophila melanogaster	37.75	4.00e-61	229.00
IUUC-Eca-034143	Equus caballus	58.56	0.00e+00	763.00
IUUC-Fca-035924	Felis catus	58.44	0.00e+00	765.00
IUUC-Fal-037387	Ficedula albicollis	58.96	0.00e+00	796.00
IUUC-Gmo-038692	Gadus morhua	70.43	3.00e-169	588.00
IUUC-Gga-040597	Gallus gallus	58.03	0.00e+00	816.00
IUUC-Gac-042004	Gasterosteus aculeatus	77.41	0.00e+00	1069.00
IUUC-Gma-044134	Glycine max	52.82	3.00e-98	353.00
IUUC-Ggo-044761	Gorilla gorilla	65.76	9.00e-148	517.00
IUUC-Hsa-045698	Homo sapiens	66.75	3.00e-154	538.00
IUUC-Hvu-047649	Hordeum vulgare	50.50	4.00e-98	353.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	59.18	0.00e+00	753.00
IUUC-Lch-049674	Latimeria chalumnae	55.84	0.00e+00	758.00
IUUC-Lpe-051554	Leersia perrieri	51.49	5.00e-100	359.00
IUUC-Loc-052623	Lepisosteus oculatus	66.39	0.00e+00	919.00
IUUC-Laf-054587	Loxodonta africana	58.87	0.00e+00	795.00
IUUC-Mcc-055851	Macaca mulatta	65.76	9.00e-148	517.00
IUUC-Meu-056704	Macropus eugenii	58.87	0.00e+00	824.00
IUUC-Mtr-058053	Medicago truncatula	52.82	4.00e-102	365.00
IUUC-Mga-059608	Meleagris gallopavo	57.81	0.00e+00	806.00
IUUC-Mmr-061154	Microcebus murinus	57.57	0.00e+00	755.00
IUUC-Mdo-062365	Monodelphis domestica	58.01	0.00e+00	786.00
IUUC-Mmu-063754	Mus musculus	58.50	0.00e+00	765.00
IUUC-Mac-065100	Musa acuminata	50.00	1.00e-96	347.00
IUUC-Mpu-066245	Mustela putorius furo	66.27	8.00e-153	534.00
IUUC-Mlu-067692	Myotis lucifugus	58.74	0.00e+00	751.00
IUUC-Nle-070051	Nomascus leucogenys	65.51	2.00e-146	512.00
IUUC-Opr-070855	Ochotona princeps	59.69	0.00e+00	764.00
IUUC-Oan-073293	Ornithorhynchus anatinus	59.85	0.00e+00	726.00
IUUC-Ocu-074644	Oryctolagus cuniculus	59.12	0.00e+00	770.00
IUUC-Oba-075448	Oryza barthii	51.16	3.00e-99	356.00
IUUC-Obr-076385	Oryza brachyantha	50.83	5.00e-99	355.00
IUUC-Ogl-077427	Oryza glaberrima	51.16	2.00e-99	357.00
IUUC-Ogu-078062	Oryza glumaepatula	46.26	2.00e-88	320.00
IUUC-Oin-079811	Oryza indica	51.19	2.00e-96	347.00
IUUC-Olo-080245	Oryza longistaminata	51.19	3.00e-96	346.00
IUUC-Ome-081239	Oryza meridionalis	51.36	2.00e-96	347.00
IUUC-Oni-082640	Oryza nivara	51.16	3.00e-99	356.00
IUUC-Opu-083748	Oryza punctata	51.49	1.00e-99	358.00
IUUC-Oru-084609	Oryza rufipogon	51.16	3.00e-99	356.00
IUUC-Osa-085801	Oryza sativa	46.64	9.00e-90	325.00
IUUC-Ola-087483	Oryzias latipes	69.90	0.00e+00	846.00
IUUC-Oga-087964	Otolemur garnettii	58.72	0.00e+00	776.00
IUUC-Oar-089483	Ovis aries	58.95	0.00e+00	752.00
IUUC-Ptr-091387	Pan troglodytes	66.75	3.00e-154	538.00
IUUC-Pan-092623	Papio anubis	65.76	9.00e-148	517.00
IUUC-Psi-093830	Pelodiscus sinensis	59.19	0.00e+00	803.00
IUUC-Pma-094135	Petromyzon marinus	40.13	2.00e-30	125.00
IUUC-Ppa-095379	Physcomitrella patens	53.08	6.00e-92	332.00
IUUC-Pfo-096755	Poecilia formosa	76.17	0.00e+00	1117.00
IUUC-Pab-097564	Pongo abelii	52.60	5.00e-164	571.00
IUUC-Pop-099149	Populus trichocarpa	52.82	5.00e-102	365.00
IUUC-Pca-100357	Procavia capensis	73.33	2.00e-94	340.00
IUUC-Ppe-101237	Prunus persica	52.49	8.00e-101	361.00
IUUC-Pva-102397	Pteropus vampyrus	55.89	0.00e+00	699.00
IUUC-Rno-105349	Rattus norvegicus	59.43	0.00e+00	783.00
IUUC-Smo-109409	Selaginella moellendorffii	52.23	4.00e-95	342.00
IUUC-Sit-110360	Setaria italica	51.16	6.00e-99	355.00
IUUC-Sly-111307	Solanum lycopersicum	51.66	3.00e-96	346.00
IUUC-Stu-112462	Solanum tuberosum	51.19	2.00e-92	333.00
IUUC-Sar-112953	Sorex araneus	59.65	9.00e-79	288.00
IUUC-Sbi-114389	Sorghum bicolor	44.97	1.00e-87	318.00
IUUC-Ssc-115949	Sus scrofa	55.34	7.00e-156	543.00
IUUC-Tgu-117461	Taeniopygia guttata	57.94	0.00e+00	809.00
IUUC-Tru-117865	Takifugu rubripes	74.22	0.00e+00	1081.00
IUUC-Tsy-119036	Tarsius syrichta	70.08	9.00e-50	191.00
IUUC-Tni-120903	Tetraodon nigroviridis	69.15	0.00e+00	983.00
IUUC-Tca-121185	Theobroma cacao	51.16	3.00e-99	357.00
IUUC-Tae-125263	Triticum aestivum	50.83	2.00e-98	353.00
IUUC-Tur-126181	Triticum urartu	46.10	9.00e-88	318.00
IUUC-Tbe-127518	Tupaia belangeri	60.50	6.00e-69	255.00
IUUC-Ttr-128172	Tursiops truncatus	57.57	0.00e+00	744.00
IUUC-Vvi-131489	Vitis vinifera	53.49	4.00e-102	365.00
IUUC-Xtr-132915	Xenopus tropicalis	57.72	0.00e+00	797.00
IUUC-Xma-134133	Xiphophorus maculatus	75.74	0.00e+00	1106.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence