iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141750.6	ENST00000333461.5	ENSP00000327509.5
ENSG00000141750.6	ENST00000584501.1	ENSP00000463299.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Variation
ClinVar
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-13	51.9	294	350

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++   +ly + +q++++L l+ Gd + ++  ++ +e+W+kg  +   + G+fP+nFv++++
   Q: 294  MYSYVALYKFLPQENNDLALQPGDRIMLV--DDSNEDWWKG--KIGDRVGFFPANFVQRVR 350
           567789**********************9..999*******..89*************996 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MTEMSEKENE PDDAATHSPP GTVSALQETK LQRFKRSLSL KTILRSKSLE NFFLRSGSEL 60
KCPTEVLLTP PTPLPPPSPP PTASDRGLAT PSPSPCPVPR PLAALKPVRL HSFQEHVFKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGGCG GGCGCAGCGG ACGGCGGAGC CGGCTGGACA CGGACAGCTC CTTGGCTCCC 60
TCCCTCGGCT CATCCCCGCG GCCCCACTTC CCTCCTCCCC GCGCTGCGAG CAGCATCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002219--PE/DAG-bd
IPR001452--SH3_domain

PROSITE

PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0035556--P:intracellular signal transduction

KEGG

hsa:342667

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001739	Ailuropoda melanoleuca	86.62	0.00e+00	632.00
IUUC-Aca-004347	Anolis carolinensis	66.67	9.00e-139	486.00
IUUC-Ame-011746	Astyanax mexicanus	51.47	4.00e-79	288.00
IUUC-Bta-012329	Bos taurus	92.60	0.00e+00	683.00
IUUC-Cja-019986	Callithrix jacchus	85.13	2.00e-162	565.00
IUUC-Cfa-020849	Canis familiaris	92.70	0.00e+00	629.00
IUUC-Cpo-021826	Cavia porcellus	77.62	2.00e-167	582.00
IUUC-Csa-023790	Chlorocebus sabaeus	97.57	0.00e+00	669.00
IUUC-Csv-026345	Ciona savignyi	30.77	1.00e-26	114.00
IUUC-Eca-034070	Equus caballus	89.81	0.00e+00	638.00
IUUC-Eeu-035137	Erinaceus europaeus	90.45	4.00e-177	613.00
IUUC-Fca-036390	Felis catus	92.21	0.00e+00	655.00
IUUC-Gmo-039419	Gadus morhua	44.91	2.00e-86	312.00
IUUC-Gac-042459	Gasterosteus aculeatus	52.14	1.00e-96	346.00
IUUC-Itr-048035	Ictidomys tridecemlineatus	92.46	0.00e+00	667.00
IUUC-Kpa-049104	Komagataella pastoris	51.02	2.00e-11	63.20
IUUC-Lch-050190	Latimeria chalumnae	61.14	9.00e-114	403.00
IUUC-Loc-052543	Lepisosteus oculatus	54.91	4.00e-116	411.00
IUUC-Laf-054534	Loxodonta africana	89.54	0.00e+00	649.00
IUUC-Mcc-055463	Macaca mulatta	98.30	0.00e+00	674.00
IUUC-Meu-056629	Macropus eugenii	84.86	2.00e-92	332.00
IUUC-Mmr-061393	Microcebus murinus	89.32	0.00e+00	631.00
IUUC-Mdo-062672	Monodelphis domestica	87.38	0.00e+00	634.00
IUUC-Mmu-064387	Mus musculus	93.43	0.00e+00	638.00
IUUC-Mpu-065879	Mustela putorius furo	82.69	2.00e-176	611.00
IUUC-Mlu-067429	Myotis lucifugus	90.17	0.00e+00	657.00
IUUC-Opr-071082	Ochotona princeps	89.32	0.00e+00	672.00
IUUC-Ont-071356	Oreochromis niloticus	50.12	2.00e-96	345.00
IUUC-Ocu-074933	Oryctolagus cuniculus	91.24	0.00e+00	650.00
IUUC-Ola-086933	Oryzias latipes	54.66	1.00e-82	300.00
IUUC-Oga-088347	Otolemur garnettii	94.89	0.00e+00	670.00
IUUC-Oar-090001	Ovis aries	87.07	3.00e-158	551.00
IUUC-Ptr-090540	Pan troglodytes	83.94	3.00e-166	577.00
IUUC-Pan-092116	Papio anubis	90.27	0.00e+00	657.00
IUUC-Pno-095097	Phaeosphaeria nodorum	41.27	5.00e-08	51.60
IUUC-Pfo-096764	Poecilia formosa	52.24	8.00e-83	301.00
IUUC-Pab-097620	Pongo abelii	98.30	0.00e+00	676.00
IUUC-Pca-100584	Procavia capensis	81.75	5.00e-162	563.00
IUUC-Pva-102318	Pteropus vampyrus	82.97	7.00e-171	593.00
IUUC-Rno-105365	Rattus norvegicus	93.43	0.00e+00	672.00
IUUC-Sha-106697	Sarcophilus harrisii	84.65	1.00e-169	588.00
IUUC-Ssc-115284	Sus scrofa	92.96	0.00e+00	670.00
IUUC-Tru-117801	Takifugu rubripes	52.27	1.00e-90	326.00
IUUC-Tni-120544	Tetraodon nigroviridis	46.35	7.00e-85	307.00
IUUC-Xtr-131960	Xenopus tropicalis	64.29	3.00e-120	425.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence