iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.40e-13	48.4	321	377

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +k ++++l+d++aq+++eL +k+G  ++++   + de+W +g    +gk GlfP  +v+ l
   Q: 321  QKPQCRALFDFDAQSEGELDFKEGTLIELV--SQIDENWYEG--RVNGKTGLFPVTYVQVL 377
           6779**************************..999*******..8************9865 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis (PubMed:14622579, PubMed:21029864). By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion (PubMed:21029864). In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels (PubMed:22157748). Plays a minor role in responses to mechanical stimuli (PubMed:17928447). Plays a minor role in unc-26/synaptojanin localization to synapses (PubMed:14622579).

Protein Sequence
(Fasta)

MSLSGLRKQF NKANQYLSET MGAAEPTKLD DVFNEMEKNV DTTYNLITDL VAGTNEYLQP 60
NPATRAKMAT QVALSKVRGT TKTSPYPQTE GMLADVMQKY GQQLGDNSDL GKSLNDAAET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAATGTCG TTGTCGGGGT TACGTAAGCA ATTCAACAAG GCGAATCAAT ACCTTTCGGA 60
GACGATGGGC GCCGCAGAGC CAACAAAACT TGACGATGTG TTCAATGAAA TGGAGAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0472--Membrane
KW-1210--Necrosis
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR028501--Endophilin-A
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50002--SH3

Pfam

PF03114--BAR
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00721--BAR
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0016020--C:membrane
GO:0031594--C:neuromuscular junction
GO:0008021--C:synaptic vesicle
GO:0072583--P:clathrin-dependent endocytosis
GO:0010940--P:positive regulation of necrotic cell death
GO:0012501--P:programmed cell death

KEGG

cel:CELE_T04D1.3

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001598	Ailuropoda melanoleuca	45.26	2.00e-89	320.00
IUUC-Apl-004209	Anas platyrhynchos	44.35	3.00e-84	303.00
IUUC-Aca-004816	Anolis carolinensis	45.55	1.00e-95	342.00
IUUC-Ame-011714	Astyanax mexicanus	45.29	3.00e-98	350.00
IUUC-Bgr-012305	Blumeria graminis	37.74	3.00e-09	56.60
IUUC-Bta-012875	Bos taurus	45.31	4.00e-95	340.00
IUUC-Bci-013864	Botrytis cinerea	39.62	5.00e-10	59.30
IUUC-Bdi-014394	Brachypodium distachyon	47.83	6.00e-07	47.40
IUUC-Cja-019400	Callithrix jacchus	45.55	4.00e-92	329.00
IUUC-Cfa-020979	Canis familiaris	43.60	2.00e-83	301.00
IUUC-Cpo-021364	Cavia porcellus	44.99	1.00e-84	305.00
IUUC-Csa-023447	Chlorocebus sabaeus	44.76	1.00e-89	322.00
IUUC-Cho-024348	Choloepus hoffmanni	43.72	1.00e-93	335.00
IUUC-Cin-025799	Ciona intestinalis	44.39	1.00e-86	311.00
IUUC-Csv-026266	Ciona savignyi	42.06	1.00e-80	291.00
IUUC-Cne-026909	Cryptococcus neoformans	51.92	3.00e-12	65.10
IUUC-Dre-028063	Danio rerio	45.81	3.00e-97	347.00
IUUC-Dno-029219	Dasypus novemcinctus	45.81	6.00e-91	326.00
IUUC-Dor-030288	Dipodomys ordii	38.85	4.00e-76	276.00
IUUC-Dse-031521	Dothistroma septosporum	45.90	1.00e-11	63.50
IUUC-Dme-031633	Drosophila melanogaster	45.14	8.00e-94	335.00
IUUC-Ete-032686	Echinops telfairi	40.60	9.00e-76	275.00
IUUC-Eca-033209	Equus caballus	44.27	3.00e-87	313.00
IUUC-Eeu-034924	Erinaceus europaeus	44.24	1.00e-93	335.00
IUUC-Fca-036354	Felis catus	42.31	3.00e-85	306.00
IUUC-Fal-036965	Ficedula albicollis	45.43	4.00e-91	326.00
IUUC-Gmo-038951	Gadus morhua	42.15	2.00e-76	278.00
IUUC-Gga-041064	Gallus gallus	46.60	4.00e-95	340.00
IUUC-Gac-042642	Gasterosteus aculeatus	44.53	3.00e-88	317.00
IUUC-Ggo-045448	Gorilla gorilla	44.50	2.00e-91	328.00
IUUC-Hsa-046112	Homo sapiens	44.50	3.00e-91	327.00
IUUC-Itr-048752	Ictidomys tridecemlineatus	44.76	3.00e-92	330.00
IUUC-Kpa-049352	Komagataella pastoris	47.17	3.00e-11	62.00
IUUC-Lch-050556	Latimeria chalumnae	46.79	7.00e-97	345.00
IUUC-Loc-052711	Lepisosteus oculatus	48.04	2.00e-102	363.00
IUUC-Laf-053698	Loxodonta africana	46.09	4.00e-97	346.00
IUUC-Mcc-055620	Macaca mulatta	42.97	3.00e-82	297.00
IUUC-Meu-056119	Macropus eugenii	43.72	2.00e-93	333.00
IUUC-Mga-059193	Meleagris gallopavo	45.90	9.00e-89	318.00
IUUC-Mvi-060542	Microbotryum violaceum	50.00	9.00e-11	58.90
IUUC-Mmr-061056	Microcebus murinus	42.86	2.00e-91	327.00
IUUC-Mdo-062217	Monodelphis domestica	43.72	6.00e-94	335.00
IUUC-Mmu-063596	Mus musculus	45.36	1.00e-92	332.00
IUUC-Mpu-066681	Mustela putorius furo	43.36	1.00e-92	331.00
IUUC-Mlu-067212	Myotis lucifugus	41.36	2.00e-87	314.00
IUUC-Nle-069316	Nomascus leucogenys	45.14	3.00e-86	310.00
IUUC-Opr-070661	Ochotona princeps	45.97	1.00e-92	332.00
IUUC-Ont-072622	Oreochromis niloticus	45.55	6.00e-97	345.00
IUUC-Oan-073674	Ornithorhynchus anatinus	43.17	9.00e-87	312.00
IUUC-Ocu-074005	Oryctolagus cuniculus	43.81	5.00e-93	332.00
IUUC-Ola-086645	Oryzias latipes	44.50	2.00e-95	340.00
IUUC-Oga-088627	Otolemur garnettii	44.57	2.00e-90	324.00
IUUC-Oar-089220	Ovis aries	45.38	3.00e-85	307.00
IUUC-Ptr-090943	Pan troglodytes	44.65	2.00e-93	333.00
IUUC-Pan-092153	Papio anubis	44.76	1.00e-89	322.00
IUUC-Psi-093052	Pelodiscus sinensis	45.55	1.00e-96	345.00
IUUC-Pma-094657	Petromyzon marinus	43.28	3.00e-81	293.00
IUUC-Pfo-096876	Poecilia formosa	44.39	4.00e-88	316.00
IUUC-Pab-097667	Pongo abelii	37.98	1.00e-64	238.00
IUUC-Pca-100102	Procavia capensis	42.97	1.00e-86	311.00
IUUC-Pva-102745	Pteropus vampyrus	43.46	2.00e-92	331.00
IUUC-Rno-105425	Rattus norvegicus	44.87	7.00e-91	325.00
IUUC-Sha-106675	Sarcophilus harrisii	44.36	2.00e-92	330.00
IUUC-Sar-113540	Sorex araneus	42.35	1.00e-81	294.00
IUUC-Ssc-115548	Sus scrofa	45.03	9.00e-92	328.00
IUUC-Tgu-117366	Taeniopygia guttata	44.50	7.00e-95	338.00
IUUC-Tru-118509	Takifugu rubripes	45.03	7.00e-96	342.00
IUUC-Tsy-119366	Tarsius syrichta	44.81	1.00e-84	305.00
IUUC-Tni-120585	Tetraodon nigroviridis	43.46	9.00e-89	318.00
IUUC-Tbe-127252	Tupaia belangeri	39.08	2.00e-29	122.00
IUUC-Ttr-128449	Tursiops truncatus	44.26	2.00e-85	307.00
IUUC-Vpa-130032	Vicugna pacos	38.19	2.00e-62	231.00
IUUC-Xtr-131935	Xenopus tropicalis	46.13	8.00e-89	318.00
IUUC-Xma-132985	Xiphophorus maculatus	44.65	5.00e-88	316.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence