iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000142347.16	ENST00000338257.12	ENSP00000344871.6
ENSG00000142347.16	ENST00000598005.1	ENSP00000469098.1
ENSG00000142347.16	ENST00000598321.5	ENSP00000469387.1
ENSG00000142347.16	ENST00000596675.1	ENSP00000469668.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.50e-13	49.7	1045	1098

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++++ly+y +q+ deL+++  +v++++   e   gW+kg   l+g++GlfP n+vek+
   Q: 1045 RCRALYQYVGQDVDELSFNVNEVIEIL--MEDPSGWWKG--RLHGQEGLFPGNYVEKI 1098
           699************************..88899*****..9*************996 PP

Organism

Homo sapiens

Functional Description
(View)

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

Protein Sequence
(Fasta)

MGSKERFHWQ SHNVKQSGVD DMVLLPQITE DAIAANLRKR FMDDYIFTYI GSVLISVNPF 60
KQMPYFTDRE IDLYQGAAQY ENPPHIYALT DNMYRNMLID CENQCVIISG ESGAGKTVAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCAAGTTCT GACCCCTCCC TTCAGGCTCA GAGCCCCAAA CAGCCAGCTC CCCGCCCCCC 60
TCCACACCCA GCTTCCCTCC CCCATGGCCT CGGCCCCTCC CGCCAAAGGA AGTGAGAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0505--Motor protein
KW-0518--Myosin
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR027401--Myosin-like_IQ_dom
IPR001609--Myosin_head_motor_dom
IPR010926--Myosin_TH1
IPR027417--P-loop_NTPase
IPR001452--SH3_domain

PROSITE

PS50096--IQ
PS51456--MYOSIN_MOTOR
PS50002--SH3
PS51757--TH1

Pfam

PF00063--Myosin_head
PF06017--Myosin_TH1
PF14604--SH3_9

PRINTS

PR00193--MYOSINHEAVY
PR00452--SH3DOMAIN

SMART

SM00242--MYSc
SM00326--SH3

Gene Ontology

GO:0016461--C:unconventional myosin complex
GO:0003779--F:actin binding
GO:0005524--F:ATP binding
GO:0003774--F:motor activity

KEGG

hsa:4542

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002158	Ailuropoda melanoleuca	94.62	0.00e+00	2081.00
IUUC-Apl-003803	Anas platyrhynchos	81.34	0.00e+00	1811.00
IUUC-Ago-007771	Ashbya gossypii	56.86	5.00e-12	65.50
IUUC-Acl-008168	Aspergillus clavatus	43.62	0.00e+00	748.00
IUUC-Afl-008552	Aspergillus flavus	45.31	0.00e+00	751.00
IUUC-Afu-008958	Aspergillus fumigatus	45.19	0.00e+00	722.00
IUUC-Ang-009818	Aspergillus niger	43.72	0.00e+00	754.00
IUUC-Aor-009891	Aspergillus oryzae	45.31	0.00e+00	751.00
IUUC-Ate-010325	Aspergillus terreus	43.81	0.00e+00	749.00
IUUC-Ame-011335	Astyanax mexicanus	77.04	0.00e+00	1743.00
IUUC-Bta-012409	Bos taurus	95.17	0.00e+00	2093.00
IUUC-Cel-018582	Caenorhabditis elegans	55.26	0.00e+00	1186.00
IUUC-Cfa-020409	Canis familiaris	92.53	0.00e+00	2057.00
IUUC-Cpo-021332	Cavia porcellus	92.03	0.00e+00	2103.00
IUUC-Dre-027687	Danio rerio	76.13	0.00e+00	1724.00
IUUC-Eca-033919	Equus caballus	81.29	0.00e+00	1677.00
IUUC-Fca-036174	Felis catus	88.73	0.00e+00	1887.00
IUUC-Fal-037393	Ficedula albicollis	82.84	0.00e+00	1815.00
IUUC-Gga-040323	Gallus gallus	82.99	0.00e+00	1838.00
IUUC-Ggo-045277	Gorilla gorilla	97.44	0.00e+00	2097.00
IUUC-Itr-048108	Ictidomys tridecemlineatus	93.21	0.00e+00	2056.00
IUUC-Loc-052303	Lepisosteus oculatus	78.83	0.00e+00	1758.00
IUUC-Laf-054277	Loxodonta africana	79.42	0.00e+00	1622.00
IUUC-Mcc-054773	Macaca mulatta	98.28	0.00e+00	2181.00
IUUC-Mmr-061357	Microcebus murinus	94.90	0.00e+00	2115.00
IUUC-Mdo-062467	Monodelphis domestica	87.88	0.00e+00	1989.00
IUUC-Mmu-063711	Mus musculus	93.72	0.00e+00	2076.00
IUUC-Mpu-066658	Mustela putorius furo	94.90	0.00e+00	2098.00
IUUC-Nfi-068411	Neosartorya fischeri	45.67	0.00e+00	720.00
IUUC-Ont-072236	Oreochromis niloticus	77.09	0.00e+00	1718.00
IUUC-Oan-073284	Ornithorhynchus anatinus	79.64	6.00e-179	620.00
IUUC-Ocu-074538	Oryctolagus cuniculus	94.62	0.00e+00	2111.00
IUUC-Ola-086639	Oryzias latipes	75.72	0.00e+00	1686.00
IUUC-Oga-088985	Otolemur garnettii	94.80	0.00e+00	2066.00
IUUC-Oar-089266	Ovis aries	88.33	0.00e+00	1885.00
IUUC-Pan-092029	Papio anubis	98.46	0.00e+00	2185.00
IUUC-Psi-094016	Pelodiscus sinensis	63.20	0.00e+00	1300.00
IUUC-Pfo-096319	Poecilia formosa	76.43	0.00e+00	1720.00
IUUC-Rno-105992	Rattus norvegicus	93.72	0.00e+00	2080.00
IUUC-Sha-107424	Sarcophilus harrisii	86.31	0.00e+00	1973.00
IUUC-Ssc-115400	Sus scrofa	95.90	0.00e+00	2096.00
IUUC-Tru-118665	Takifugu rubripes	75.66	0.00e+00	1720.00
IUUC-Tre-122048	Trichoderma reesei	43.70	0.00e+00	734.00
IUUC-Vda-130020	Verticillium dahliae	44.38	0.00e+00	724.00
IUUC-Xtr-131936	Xenopus tropicalis	77.69	0.00e+00	1781.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence