iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045743

UUCD1 version

UUC-HoS-01254

Ensembl Protein ID

ENSP00000311949.6

UniProt Accession

Q58WW2; A2A295; B4DNB8; Q7L8I0; Q8IXH3; Q8TB19; DCAF6_HUMAN

Genbank Protein ID

AAX09330.1; ABG76793.1; AAO15301.1; BAG60180.1; CAI20078.1; CAI20078.1; CAI20078.1; CAI20078.1; CAI22478.1; CAI22478.1; CAI22478.1; CAI22478.1; CAI22481.1; CAI22481.1; CAI22481.1; CAI22481.1; CAI22625.1; CAI22625.1; CAI22625.1; CAI22625.1; CAM28213.1; CAM28213.1; CAM28213.1; CAM28213.1; CAM28292.1; CAM28292.1; CAM28292.1; CAM28292.1; CAM28293.1; CAM28293.1; CAM28293.1; CAM28293.1; CAM28303.1; CAM28303.1; CAM28303.1; CAM28303.1; EAW90809.1; AAH25262.2; CAB66672.2

Protein Name

DDB1- and CUL4-associated factor 6; Androgen receptor complex-associated protein; IQ motif and WD repeat-containing protein 1; Nuclear receptor interaction protein

Genbank Nucleotide ID

AY766164; DQ768089; AF116725; AK297847; Z97876; AL031287; AL033531; AL033532; AL033531; AL031287; AL033532; Z97876; AL031287; AL033531; AL033532; Z97876; AL033532; AL031287; AL033531; Z97876; Z97876; AL031287; AL033531; AL033532; AL033531; AL031287; AL033532; Z97876; AL031287; AL033531; AL033532; Z97876; AL033532; AL031287; AL033531; Z97876; CH471067; BC025262; AL136738

Gene Name

DCAF6; IQWD1; MSTP055

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143164.15	ENST00000367843.7	ENSP00000356817.3
ENSG00000143164.15	ENST00000470721.5	ENSP00000432304.1
ENSG00000143164.15	ENST00000312263.10	ENSP00000311949.6
ENSG00000143164.15	ENST00000367840.3	ENSP00000356814.3
ENSG00000143164.15	ENST00000432587.6	ENSP00000396238.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-16	60.3	92	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgti 25
           gH + +++ +f    +d+ +vs+s+Dg+i
   Q: 92   GHRANIFSAKFlpctNDKQIVSCSGDGVI 120
           8************9777**********98 PP

Organism

Homo sapiens

Functional Description
(View)

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH DGCVNTICWN 60
DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA KFLPCTNDKQ IVSCSGDGVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTTATCGA GGAGCCGGTG GTAGGTGGCC CGCAGGCCTC GGGCACCGGC GGCCGACATC 60
GCCGCCGAGG GATCGTTGGC AGCCGGGTGG GAGCGTGGCT GTGTTCTCGT CCCTGGCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50096--IQ
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005634--C:nucleus
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination

KEGG

hsa:55827

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001399	Ailuropoda melanoleuca	93.91	0.00e+00	869.00
IUUC-Apl-003181	Anas platyrhynchos	80.21	0.00e+00	1206.00
IUUC-Aca-004953	Anolis carolinensis	85.58	0.00e+00	677.00
IUUC-Acl-008211	Aspergillus clavatus	27.64	4.00e-27	117.00
IUUC-Afu-008828	Aspergillus fumigatus	28.05	7.00e-28	119.00
IUUC-Ate-010555	Aspergillus terreus	25.85	3.00e-25	111.00
IUUC-Ame-011314	Astyanax mexicanus	85.59	0.00e+00	665.00
IUUC-Bta-013552	Bos taurus	90.23	0.00e+00	1481.00
IUUC-Cja-019015	Callithrix jacchus	98.91	0.00e+00	869.00
IUUC-Cfa-021249	Canis familiaris	96.30	0.00e+00	834.00
IUUC-Cpo-021903	Cavia porcellus	94.13	0.00e+00	862.00
IUUC-Csa-023744	Chlorocebus sabaeus	99.13	0.00e+00	870.00
IUUC-Cho-024527	Choloepus hoffmanni	80.36	5.00e-178	618.00
IUUC-Dre-028040	Danio rerio	86.16	0.00e+00	667.00
IUUC-Dno-029777	Dasypus novemcinctus	96.74	0.00e+00	848.00
IUUC-Dor-030879	Dipodomys ordii	86.96	0.00e+00	798.00
IUUC-Ete-032607	Echinops telfairi	68.59	4.00e-140	492.00
IUUC-Eca-033396	Equus caballus	94.08	0.00e+00	1403.00
IUUC-Eeu-034944	Erinaceus europaeus	70.74	6.00e-147	515.00
IUUC-Fca-036020	Felis catus	89.11	0.00e+00	1455.00
IUUC-Fal-037527	Ficedula albicollis	74.19	0.00e+00	1141.00
IUUC-Gmo-039347	Gadus morhua	83.19	0.00e+00	638.00
IUUC-Gga-040564	Gallus gallus	77.88	0.00e+00	1213.00
IUUC-Gac-042029	Gasterosteus aculeatus	84.46	0.00e+00	649.00
IUUC-Ggo-045634	Gorilla gorilla	98.81	0.00e+00	714.00
IUUC-Itr-048064	Ictidomys tridecemlineatus	92.51	0.00e+00	1430.00
IUUC-Lch-050457	Latimeria chalumnae	81.64	0.00e+00	700.00
IUUC-Loc-052880	Lepisosteus oculatus	87.22	0.00e+00	667.00
IUUC-Lma-053032	Leptosphaeria maculans	29.74	1.00e-27	119.00
IUUC-Laf-053836	Loxodonta africana	90.38	0.00e+00	1143.00
IUUC-Mcc-055749	Macaca mulatta	99.13	0.00e+00	868.00
IUUC-Mga-059293	Meleagris gallopavo	75.78	0.00e+00	1115.00
IUUC-Mmr-060923	Microcebus murinus	97.61	0.00e+00	870.00
IUUC-Mdo-063056	Monodelphis domestica	83.33	0.00e+00	1304.00
IUUC-Mmu-063121	Mus musculus	86.21	0.00e+00	1456.00
IUUC-Mpu-066035	Mustela putorius furo	91.69	0.00e+00	766.00
IUUC-Mlu-067903	Myotis lucifugus	88.91	0.00e+00	1402.00
IUUC-Nfi-068606	Neosartorya fischeri	27.76	2.00e-27	118.00
IUUC-Nle-069415	Nomascus leucogenys	99.53	0.00e+00	826.00
IUUC-Opr-070809	Ochotona princeps	78.53	5.00e-141	495.00
IUUC-Ont-071470	Oreochromis niloticus	84.46	0.00e+00	649.00
IUUC-Oan-072748	Ornithorhynchus anatinus	89.85	1.00e-131	462.00
IUUC-Ocu-073865	Oryctolagus cuniculus	91.08	0.00e+00	1390.00
IUUC-Ola-086755	Oryzias latipes	83.33	0.00e+00	644.00
IUUC-Oga-088309	Otolemur garnettii	79.13	0.00e+00	700.00
IUUC-Oar-090264	Ovis aries	96.30	0.00e+00	864.00
IUUC-Ptr-090603	Pan troglodytes	99.57	0.00e+00	873.00
IUUC-Pan-092480	Papio anubis	97.14	0.00e+00	1562.00
IUUC-Psi-092973	Pelodiscus sinensis	80.95	0.00e+00	957.00
IUUC-Pfo-096506	Poecilia formosa	83.90	0.00e+00	644.00
IUUC-Pab-097581	Pongo abelii	91.14	0.00e+00	1425.00
IUUC-Pca-100155	Procavia capensis	88.67	0.00e+00	748.00
IUUC-Pva-103022	Pteropus vampyrus	97.18	0.00e+00	704.00
IUUC-Pte-104187	Pyrenophora teres	30.00	2.00e-28	121.00
IUUC-Pyt-104546	Pyrenophora triticirepentis	29.35	3.00e-27	117.00
IUUC-Rno-105851	Rattus norvegicus	92.83	0.00e+00	863.00
IUUC-Sha-106790	Sarcophilus harrisii	80.25	0.00e+00	1283.00
IUUC-Sja-107779	Schizosaccharomyces japonicus	32.59	8.00e-35	142.00
IUUC-Spo-108129	Schizosaccharomyces pombe	31.86	2.00e-33	138.00
IUUC-Ssc-115801	Sus scrofa	83.45	5.00e-121	427.00
IUUC-Tgu-116760	Taeniopygia guttata	79.10	0.00e+00	1154.00
IUUC-Tru-118422	Takifugu rubripes	84.18	0.00e+00	644.00
IUUC-Tni-120340	Tetraodon nigroviridis	84.57	0.00e+00	641.00
IUUC-Tbe-127997	Tupaia belangeri	74.71	6.00e-166	578.00
IUUC-Ttr-129311	Tursiops truncatus	87.85	0.00e+00	744.00
IUUC-Vpa-130145	Vicugna pacos	96.02	0.00e+00	783.00
IUUC-Xtr-132496	Xenopus tropicalis	63.21	0.00e+00	982.00
IUUC-Xma-133610	Xiphophorus maculatus	84.75	0.00e+00	647.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence