iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/Other	E2/Other	17825256; 19101823; 20018847; 21264253

Organism

Homo sapiens

Functional Description
(View)

E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.

Protein Sequence
(Fasta)

MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK 60
EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGGTGGCT CACGCCTGTA ATCCCAGCAC CTTGGGAGGC TGAGGCAGGT GGATCACCTG 60
AGGTCAGGAG TTCAAGACCA ACCTGGCCAA CATGGCGAAA CCCGGTCTCT ACTAAAAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016135--UBQ-conjugating_enzyme/RWD
IPR014806--Ufc1

Pfam

PF08694--UFC1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0071568--F:UFM1 transferase activity
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0034976--P:response to endoplasmic reticulum stress

KEGG

hsa:51506

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000219	Aegilops tauschii	68.35	2.00e-30	124.00
IUUC-Aml-001773	Ailuropoda melanoleuca	97.60	2.00e-96	343.00
IUUC-Atr-002519	Amborella trichopoda	65.84	1.00e-67	248.00
IUUC-Aca-004597	Anolis carolinensis	89.02	5.00e-88	316.00
IUUC-Aly-005549	Arabidopsis lyrata	66.67	5.00e-66	243.00
IUUC-Ath-007416	Arabidopsis thaliana	66.67	5.00e-66	243.00
IUUC-Ame-011281	Astyanax mexicanus	87.35	4.00e-87	313.00
IUUC-Bta-012940	Bos taurus	99.40	1.00e-97	348.00
IUUC-Bdi-014987	Brachypodium distachyon	62.96	5.00e-62	229.00
IUUC-Bol-016532	Brassica oleracea	66.05	5.00e-66	243.00
IUUC-Bra-017971	Brassica rapa	66.05	3.00e-66	243.00
IUUC-Cel-018620	Caenorhabditis elegans	71.88	7.00e-72	262.00
IUUC-Cja-019762	Callithrix jacchus	100.00	2.00e-97	347.00
IUUC-Cfa-021172	Canis familiaris	98.80	2.00e-97	347.00
IUUC-Cpo-021575	Cavia porcellus	99.40	2.00e-97	347.00
IUUC-Cre-022894	Chlamydomonas reinhardtii	60.62	3.00e-60	224.00
IUUC-Csa-024240	Chlorocebus sabaeus	95.81	1.00e-93	335.00
IUUC-Cho-024457	Choloepus hoffmanni	100.00	4.00e-29	120.00
IUUC-Cin-025708	Ciona intestinalis	77.44	7.00e-77	279.00
IUUC-Csv-026307	Ciona savignyi	78.05	3.00e-77	280.00
IUUC-Cgl-026671	Colletotrichum gloeosporioides	24.47	3.10e-02	32.30
IUUC-Dre-027752	Danio rerio	87.80	7.00e-88	315.00
IUUC-Dno-028957	Dasypus novemcinctus	97.90	2.00e-82	297.00
IUUC-Dor-030637	Dipodomys ordii	99.40	1.00e-97	348.00
IUUC-Dme-032033	Drosophila melanogaster	79.27	3.00e-81	293.00
IUUC-Ete-033056	Echinops telfairi	97.01	1.00e-95	341.00
IUUC-Eca-034260	Equus caballus	100.00	5.00e-98	349.00
IUUC-Eeu-034785	Erinaceus europaeus	60.00	1.00e-19	87.80
IUUC-Fca-035879	Felis catus	99.40	4.00e-96	343.00
IUUC-Gmo-039023	Gadus morhua	82.82	6.00e-85	306.00
IUUC-Gga-040475	Gallus gallus	84.03	3.00e-73	266.00
IUUC-Gac-041574	Gasterosteus aculeatus	78.66	7.00e-79	285.00
IUUC-Gma-043338	Glycine max	63.58	2.00e-65	241.00
IUUC-Ggo-044713	Gorilla gorilla	98.43	3.00e-73	266.00
IUUC-Hvu-047147	Hordeum vulgare	63.35	1.00e-61	228.00
IUUC-Itr-048742	Ictidomys tridecemlineatus	100.00	5.00e-98	349.00
IUUC-Lch-049654	Latimeria chalumnae	87.43	7.00e-89	319.00
IUUC-Lpe-051422	Leersia perrieri	63.35	4.00e-62	230.00
IUUC-Loc-051920	Lepisosteus oculatus	89.63	2.00e-89	321.00
IUUC-Laf-054338	Loxodonta africana	100.00	5.00e-98	349.00
IUUC-Mcc-054927	Macaca mulatta	100.00	5.00e-98	349.00
IUUC-Meu-056831	Macropus eugenii	96.34	3.00e-93	333.00
IUUC-Mtr-058091	Medicago truncatula	64.20	6.00e-65	239.00
IUUC-Mga-059933	Meleagris gallopavo	75.76	1.00e-44	170.00
IUUC-Mmr-061433	Microcebus murinus	98.80	2.00e-97	347.00
IUUC-Mdo-061994	Monodelphis domestica	95.73	1.00e-92	331.00
IUUC-Mmu-063398	Mus musculus	97.01	3.00e-96	343.00
IUUC-Mac-064536	Musa acuminata	62.35	3.00e-63	234.00
IUUC-Mpu-066795	Mustela putorius furo	99.40	1.00e-97	348.00
IUUC-Mlu-067983	Myotis lucifugus	97.60	9.00e-96	342.00
IUUC-Nle-069720	Nomascus leucogenys	100.00	5.00e-63	231.00
IUUC-Opr-070723	Ochotona princeps	99.40	1.00e-97	348.00
IUUC-Ont-071509	Oreochromis niloticus	80.49	1.00e-80	291.00
IUUC-Oan-073541	Ornithorhynchus anatinus	89.36	7.00e-23	98.20
IUUC-Ocu-074044	Oryctolagus cuniculus	100.00	9.00e-96	342.00
IUUC-Oba-075612	Oryza barthii	62.96	4.00e-62	230.00
IUUC-Obr-076432	Oryza brachyantha	62.96	4.00e-62	230.00
IUUC-Ogl-077071	Oryza glaberrima	62.96	4.00e-62	230.00
IUUC-Ogu-078427	Oryza glumaepatula	62.96	4.00e-62	230.00
IUUC-Oin-079963	Oryza indica	62.96	4.00e-62	230.00
IUUC-Olo-080455	Oryza longistaminata	62.96	4.00e-62	230.00
IUUC-Oni-082562	Oryza nivara	62.96	4.00e-62	230.00
IUUC-Opu-083688	Oryza punctata	62.73	1.00e-61	229.00
IUUC-Oru-084472	Oryza rufipogon	62.96	4.00e-62	230.00
IUUC-Osa-085623	Oryza sativa	62.96	4.00e-62	230.00
IUUC-Oga-088366	Otolemur garnettii	100.00	5.00e-98	349.00
IUUC-Oar-089754	Ovis aries	98.80	4.00e-97	346.00
IUUC-Ptr-090679	Pan troglodytes	99.40	9.00e-98	348.00
IUUC-Psi-093472	Pelodiscus sinensis	92.74	4.00e-68	249.00
IUUC-Ppa-095568	Physcomitrella patens	67.90	5.00e-68	249.00
IUUC-Pfo-097314	Poecilia formosa	79.88	8.00e-80	288.00
IUUC-Pab-098562	Pongo abelii	99.40	1.00e-97	348.00
IUUC-Pop-099506	Populus trichocarpa	64.20	3.00e-65	241.00
IUUC-Pca-101030	Procavia capensis	89.76	3.00e-85	306.00
IUUC-Ppe-101757	Prunus persica	64.81	1.00e-65	241.00
IUUC-Pva-102948	Pteropus vampyrus	98.80	3.00e-97	347.00
IUUC-Rno-105014	Rattus norvegicus	98.20	4.00e-97	346.00
IUUC-Sha-107297	Sarcophilus harrisii	95.21	2.00e-94	337.00
IUUC-Sit-110317	Setaria italica	62.35	3.00e-61	227.00
IUUC-Sly-111332	Solanum lycopersicum	64.81	4.00e-65	240.00
IUUC-Stu-112719	Solanum tuberosum	64.81	4.00e-65	240.00
IUUC-Sbi-114869	Sorghum bicolor	62.35	2.00e-61	228.00
IUUC-Ssc-116009	Sus scrofa	100.00	5.00e-98	349.00
IUUC-Tru-117527	Takifugu rubripes	82.32	6.00e-82	296.00
IUUC-Tsy-119195	Tarsius syrichta	95.04	1.00e-76	277.00
IUUC-Tni-120417	Tetraodon nigroviridis	80.49	8.00e-81	292.00
IUUC-Tca-120972	Theobroma cacao	66.05	6.00e-66	243.00
IUUC-Tae-124763	Triticum aestivum	63.35	2.00e-61	228.00
IUUC-Tur-126831	Triticum urartu	63.35	1.00e-61	228.00
IUUC-Tbe-128019	Tupaia belangeri	100.00	4.00e-82	296.00
IUUC-Ttr-129013	Tursiops truncatus	99.40	1.00e-97	348.00
IUUC-Vvi-131214	Vitis vinifera	64.81	1.00e-64	238.00
IUUC-Xtr-132182	Xenopus tropicalis	88.41	2.00e-88	317.00
IUUC-Xma-133877	Xiphophorus maculatus	79.88	1.00e-79	288.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence