iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045862

UUCD1 version

UUC-HoS-00405

Ensembl Protein ID

ENSP00000355958.4

UniProt Accession

Q9NZJ0; A8K8H8; D3DT98; Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; DTL_HUMAN

Genbank Protein ID

AAK54706.1; ABG23317.1; AAF35182.1; BAA91355.1; BAA91552.1; BAA91586.1; BAB55267.1; BAF85032.1; CAH70697.1; CAH70697.1; CAH70697.1; CAH73803.1; CAH73803.1; CAH73803.1; EAW93395.1; EAW93397.1; AAH33540.1; AAH33297.1

Protein Name

Denticleless protein homolog; DDB1- and CUL4-associated factor 2; Lethal(2) denticleless protein homolog; Retinoic acid-regulated nuclear matrix-associated protein

Genbank Nucleotide ID

AF345896; DQ641253; AF195765; AK000742; AK001206; AK001261; AK027651; AK292343; AL606468; AC092814; AL592297; AL592297; AC092814; AL606468; CH471100; CH471100; BC033540; BC033297

Gene Name

DTL; CDT2; CDW1; DCAF2; L2DTL; RAMP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143476.17	ENST00000366991.4	ENSP00000355958.4
ENSG00000143476.17	ENST00000542077.5	ENSP00000443870.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	19595719; 20932471; 21035370; 18703516; 20086099; 19081066

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-33	114.1	358	395

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           gH+ +vt++++  sd t ++++sdD+t+k+W+l +g  
   Q: 358  GHSQEVTSVCWcpSDfTKIATCSDDNTLKIWRLNRGLE 395
           8***********999*****************988866 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613).

Protein Sequence
(Fasta)

MLFNSVLRQP QLGVLRNGWS SQYPLQSLLT GYQCSGNDEH TSYGETGVPV PPFGCTFSSA 60
PNMEHVLAVA NEEGFVRLYN TESQSFRKKC FKEWMAHWNA VFDLAWVPGE LKLVTAAGDQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTACGCATG CGCCCTGGTC ACCCCGCGGT TTGTCCGCGC CTCTGCTACC CCCTGCGCAG 60
GCGCTCAAGG AGCTCTTGGA CTCCAGGTTC CCGCGGCTGG GAGAAAAGGA GGCGGGGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005694--C:chromosome
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0006260--P:DNA replication
GO:0031572--P:G2 DNA damage checkpoint
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:51514

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002111	Ailuropoda melanoleuca	93.29	0.00e+00	1266.00
IUUC-Atr-003097	Amborella trichopoda	35.36	4.00e-63	236.00
IUUC-Apl-004088	Anas platyrhynchos	62.89	0.00e+00	806.00
IUUC-Aca-004732	Anolis carolinensis	56.94	0.00e+00	684.00
IUUC-Aly-005686	Arabidopsis lyrata	33.15	1.00e-57	217.00
IUUC-Ath-006970	Arabidopsis thaliana	33.24	7.00e-57	214.00
IUUC-Acl-008219	Aspergillus clavatus	24.72	2.00e-22	101.00
IUUC-Afu-008784	Aspergillus fumigatus	24.84	4.00e-23	103.00
IUUC-Ani-009304	Aspergillus nidulans	26.75	2.00e-18	87.80
IUUC-Ang-009842	Aspergillus niger	24.52	1.00e-24	108.00
IUUC-Aor-009883	Aspergillus oryzae	25.28	1.00e-22	102.00
IUUC-Ate-010454	Aspergillus terreus	26.71	8.00e-23	101.00
IUUC-Ame-010949	Astyanax mexicanus	47.77	3.00e-166	578.00
IUUC-Bta-012333	Bos taurus	90.55	0.00e+00	1221.00
IUUC-Bci-013733	Botrytis cinerea	26.86	1.00e-21	98.60
IUUC-Bdi-014494	Brachypodium distachyon	33.89	3.00e-55	209.00
IUUC-Bol-015301	Brassica oleracea	35.44	2.00e-57	216.00
IUUC-Bra-017384	Brassica rapa	33.33	1.00e-57	217.00
IUUC-Cel-018498	Caenorhabditis elegans	27.60	4.00e-32	133.00
IUUC-Cja-019534	Callithrix jacchus	97.54	0.00e+00	1367.00
IUUC-Cfa-020847	Canis familiaris	93.01	0.00e+00	1233.00
IUUC-Cpo-021695	Cavia porcellus	89.65	0.00e+00	1201.00
IUUC-Cre-022762	Chlamydomonas reinhardtii	29.10	5.00e-41	164.00
IUUC-Csa-023748	Chlorocebus sabaeus	98.36	0.00e+00	1358.00
IUUC-Cho-024445	Choloepus hoffmanni	73.56	0.00e+00	952.00
IUUC-Cgl-026664	Colletotrichum gloeosporioides	24.50	3.00e-17	84.00
IUUC-Cne-027008	Cryptococcus neoformans	23.91	1.00e-12	70.10
IUUC-Dre-027536	Danio rerio	46.10	1.00e-162	566.00
IUUC-Dno-030035	Dasypus novemcinctus	82.35	0.00e+00	1140.00
IUUC-Dor-030814	Dipodomys ordii	82.34	5.00e-141	495.00
IUUC-Dse-031354	Dothistroma septosporum	23.85	6.00e-26	112.00
IUUC-Dme-031691	Drosophila melanogaster	42.33	1.00e-81	298.00
IUUC-Ete-032814	Echinops telfairi	81.01	0.00e+00	815.00
IUUC-Eca-033332	Equus caballus	93.15	0.00e+00	1240.00
IUUC-Fca-035571	Felis catus	93.15	0.00e+00	1232.00
IUUC-Fal-037421	Ficedula albicollis	61.01	0.00e+00	779.00
IUUC-Fox-038069	Fusarium oxysporum	23.19	8.00e-16	79.00
IUUC-Fso-038192	Fusarium solani	22.72	3.00e-16	80.50
IUUC-Gmo-039365	Gadus morhua	66.10	1.00e-158	553.00
IUUC-Ggr-039904	Gaeumannomyces graminis	24.56	4.00e-16	80.10
IUUC-Gga-041153	Gallus gallus	61.90	0.00e+00	797.00
IUUC-Gac-041984	Gasterosteus aculeatus	61.38	4.00e-160	558.00
IUUC-Gma-043734	Glycine max	35.08	3.00e-56	213.00
IUUC-Ggo-044419	Gorilla gorilla	99.32	0.00e+00	1349.00
IUUC-Hvu-047728	Hordeum vulgare	33.06	3.00e-58	219.00
IUUC-Itr-048786	Ictidomys tridecemlineatus	93.70	0.00e+00	1302.00
IUUC-Lch-050616	Latimeria chalumnae	54.91	0.00e+00	669.00
IUUC-Lpe-051222	Leersia perrieri	33.81	3.00e-55	209.00
IUUC-Loc-052564	Lepisosteus oculatus	52.19	2.00e-175	608.00
IUUC-Lma-053098	Leptosphaeria maculans	25.22	4.00e-25	109.00
IUUC-Laf-053892	Loxodonta africana	88.93	0.00e+00	1169.00
IUUC-Mcc-055854	Macaca mulatta	98.08	0.00e+00	1350.00
IUUC-Mor-057144	Magnaporthe oryzae	26.55	1.00e-16	81.60
IUUC-Mtr-058510	Medicago truncatula	33.43	4.00e-54	206.00
IUUC-Mla-058823	Melampsora laricipopulina	25.64	6.00e-21	95.90
IUUC-Mga-060128	Meleagris gallopavo	61.55	0.00e+00	805.00
IUUC-Mvi-060475	Microbotryum violaceum	31.50	1.00e-42	167.00
IUUC-Mmr-061331	Microcebus murinus	94.11	0.00e+00	1259.00
IUUC-Mdo-063020	Monodelphis domestica	73.61	0.00e+00	1013.00
IUUC-Mmu-063713	Mus musculus	89.45	0.00e+00	1152.00
IUUC-Mac-064653	Musa acuminata	33.51	5.00e-56	212.00
IUUC-Mpu-066490	Mustela putorius furo	93.01	0.00e+00	1231.00
IUUC-Mlu-067900	Myotis lucifugus	90.27	0.00e+00	1184.00
IUUC-Nfi-068433	Neosartorya fischeri	25.05	2.00e-24	107.00
IUUC-Ncr-068776	Neurospora crassa	27.90	4.00e-26	113.00
IUUC-Nle-069675	Nomascus leucogenys	93.43	0.00e+00	1235.00
IUUC-Opr-070769	Ochotona princeps	68.63	0.00e+00	803.00
IUUC-Ont-071441	Oreochromis niloticus	62.53	2.00e-155	543.00
IUUC-Oan-072757	Ornithorhynchus anatinus	68.73	0.00e+00	906.00
IUUC-Ocu-074670	Oryctolagus cuniculus	94.93	0.00e+00	1292.00
IUUC-Oba-075844	Oryza barthii	32.68	5.00e-54	205.00
IUUC-Obr-076625	Oryza brachyantha	35.75	1.00e-58	220.00
IUUC-Ogl-077771	Oryza glaberrima	32.68	5.00e-54	205.00
IUUC-Ogu-078475	Oryza glumaepatula	31.56	2.00e-46	180.00
IUUC-Oin-079958	Oryza indica	32.68	4.00e-54	205.00
IUUC-Olo-080311	Oryza longistaminata	32.01	4.00e-45	175.00
IUUC-Ome-081985	Oryza meridionalis	31.84	9.00e-53	201.00
IUUC-Oni-082921	Oryza nivara	32.68	4.00e-54	205.00
IUUC-Opu-083174	Oryza punctata	31.44	1.00e-54	207.00
IUUC-Oru-084338	Oryza rufipogon	31.33	4.00e-54	205.00
IUUC-Osa-085609	Oryza sativa	41.11	5.00e-19	87.80
IUUC-Olu-087907	Ostreococcus lucimarinus	26.39	8.00e-29	121.00
IUUC-Oga-088358	Otolemur garnettii	94.52	0.00e+00	1328.00
IUUC-Oar-089994	Ovis aries	90.41	0.00e+00	1217.00
IUUC-Ptr-091338	Pan troglodytes	99.59	0.00e+00	1393.00
IUUC-Pan-091759	Papio anubis	98.22	0.00e+00	1353.00
IUUC-Psi-093211	Pelodiscus sinensis	59.65	0.00e+00	702.00
IUUC-Pma-094588	Petromyzon marinus	59.15	4.00e-99	354.00
IUUC-Pno-094964	Phaeosphaeria nodorum	25.69	4.00e-26	113.00
IUUC-Ppa-095159	Physcomitrella patens	37.88	7.00e-63	234.00
IUUC-Pfo-096592	Poecilia formosa	43.32	4.00e-146	511.00
IUUC-Pab-098597	Pongo abelii	82.35	0.00e+00	1048.00
IUUC-Pop-099255	Populus trichocarpa	36.44	5.00e-61	228.00
IUUC-Pca-100593	Procavia capensis	72.92	0.00e+00	890.00
IUUC-Ppe-101333	Prunus persica	34.96	8.00e-56	211.00
IUUC-Pva-102283	Pteropus vampyrus	88.63	0.00e+00	1162.00
IUUC-Pgr-103383	Puccinia graminis	27.56	1.00e-21	98.20
IUUC-Ptt-103974	Puccinia triticina	29.33	4.00e-20	92.80
IUUC-Pte-104329	Pyrenophora teres	24.73	2.00e-24	107.00
IUUC-Pyt-104424	Pyrenophora triticirepentis	24.89	6.00e-24	105.00
IUUC-Rno-105720	Rattus norvegicus	87.53	0.00e+00	1121.00
IUUC-Sha-106891	Sarcophilus harrisii	69.14	0.00e+00	895.00
IUUC-Sja-107723	Schizosaccharomyces japonicus	27.52	1.00e-26	114.00
IUUC-Spo-108060	Schizosaccharomyces pombe	25.69	4.00e-20	92.80
IUUC-Ssl-108481	Sclerotinia sclerotiorum	27.61	1.00e-18	88.60
IUUC-Sit-109862	Setaria italica	33.05	5.00e-55	208.00
IUUC-Sly-111468	Solanum lycopersicum	34.35	1.00e-58	221.00
IUUC-Stu-112346	Solanum tuberosum	33.90	4.00e-56	212.00
IUUC-Sar-113734	Sorex araneus	80.45	1.00e-102	367.00
IUUC-Sbi-114076	Sorghum bicolor	33.43	1.00e-56	214.00
IUUC-Sre-114918	Sporisorium reilianum	22.94	4.00e-14	73.60
IUUC-Ssc-115561	Sus scrofa	90.01	0.00e+00	1203.00
IUUC-Tgu-117011	Taeniopygia guttata	62.99	0.00e+00	778.00
IUUC-Tru-118411	Takifugu rubripes	60.45	8.00e-152	530.00
IUUC-Tsy-119367	Tarsius syrichta	83.97	0.00e+00	1089.00
IUUC-Tni-120301	Tetraodon nigroviridis	59.68	8.00e-152	530.00
IUUC-Tca-121265	Theobroma cacao	34.71	6.00e-58	218.00
IUUC-Tre-121997	Trichoderma reesei	25.89	4.00e-18	86.70
IUUC-Tvi-122292	Trichoderma virens	25.91	5.00e-19	89.70
IUUC-Tae-123660	Triticum aestivum	31.94	1.00e-56	214.00
IUUC-Tur-126794	Triticum urartu	30.93	4.00e-42	166.00
IUUC-Tme-127090	Tuber melanosporum	25.24	5.00e-17	82.00
IUUC-Tbe-127646	Tupaia belangeri	89.74	0.00e+00	790.00
IUUC-Ttr-128171	Tursiops truncatus	91.23	0.00e+00	1239.00
IUUC-Uma-129525	Ustilago maydis	25.64	4.00e-20	93.60
IUUC-Vda-129871	Verticillium dahliae	28.57	3.00e-19	90.50
IUUC-Vpa-130554	Vicugna pacos	80.33	4.00e-147	515.00
IUUC-Vvi-131698	Vitis vinifera	34.48	2.00e-59	223.00
IUUC-Xtr-131962	Xenopus tropicalis	56.99	0.00e+00	753.00
IUUC-Xma-133803	Xiphophorus maculatus	44.52	1.00e-155	543.00
IUUC-Zma-135693	Zea mays	31.56	7.00e-54	205.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence