iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143674.10	ENST00000366623.7	ENSP00000355582.3
ENSG00000143674.10	ENST00000366624.7	ENSP00000355583.3
ENSG00000143674.10	ENST00000366622.1	ENSP00000355581.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	RAID2
Protein-protein Interaction
IID	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-13	52.3	44	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvkelegkrGlfPenFvek 61
            +lydyea  +deL+l++G  v+v+      + degW+ g  + + + G+fP+n+v+ 
   Q: 44   AALYDYEARGEDELSLRRGQLVEVLsqdAAVSGDEGWWAG--QVQRRLGIFPANYVAP 99
           69***********************54444578*******..7*************86 PP

Organism

Homo sapiens

Functional Description
(View)

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Protein Sequence
(Fasta)

MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR 60
RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGCCTGG GCACGACCAT GGTGGGACGT CGCCCGCGGC TTCGGGGACC GCTGCGGCAG 60
CAGAGGCGGC TGGCCAGGAA CGCGGGCCGA GGCTGGACCC TTTGGGCAGC TAGCCCGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR016231--MLK1/MLK2/MLK4
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0042803--F:protein homodimerization activity
GO:0007257--P:activation of JUN kinase activity
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation

KEGG

hsa:84451

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005356	Anolis carolinensis	64.52	0.00e+00	1107.00
IUUC-Ame-011769	Astyanax mexicanus	59.23	0.00e+00	929.00
IUUC-Bta-012631	Bos taurus	75.21	0.00e+00	1166.00
IUUC-Cja-019307	Callithrix jacchus	89.58	0.00e+00	1467.00
IUUC-Cfa-020962	Canis familiaris	77.65	0.00e+00	1164.00
IUUC-Cpo-021521	Cavia porcellus	84.36	0.00e+00	919.00
IUUC-Csa-023781	Chlorocebus sabaeus	94.52	0.00e+00	1449.00
IUUC-Dre-027645	Danio rerio	67.68	0.00e+00	877.00
IUUC-Gmo-039264	Gadus morhua	67.28	0.00e+00	851.00
IUUC-Gga-040976	Gallus gallus	69.62	0.00e+00	1184.00
IUUC-Gac-042068	Gasterosteus aculeatus	67.33	0.00e+00	862.00
IUUC-Ggo-044536	Gorilla gorilla	97.58	0.00e+00	1602.00
IUUC-Loc-052411	Lepisosteus oculatus	59.05	0.00e+00	901.00
IUUC-Mcc-055881	Macaca mulatta	95.17	0.00e+00	1444.00
IUUC-Mdo-062770	Monodelphis domestica	83.87	0.00e+00	1108.00
IUUC-Mmu-063237	Mus musculus	68.33	0.00e+00	999.00
IUUC-Ont-071825	Oreochromis niloticus	67.52	0.00e+00	871.00
IUUC-Ocu-074362	Oryctolagus cuniculus	81.09	0.00e+00	1189.00
IUUC-Oga-087967	Otolemur garnettii	83.94	0.00e+00	1288.00
IUUC-Pfo-096763	Poecilia formosa	56.80	0.00e+00	899.00
IUUC-Rno-105010	Rattus norvegicus	68.59	0.00e+00	999.00
IUUC-Ssc-115831	Sus scrofa	77.40	0.00e+00	1159.00
IUUC-Tru-117957	Takifugu rubripes	57.53	0.00e+00	907.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence