iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.40e-12	47.7	30	84

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvkelegkrGlfPenFve 60
            +lydyea  +deL+l++G  v+v+      + degW+ g  + + + G+fP+ +v+
   Q: 30   AALYDYEARGEDELSLRRGQLVEVLsqdAAVSGDEGWWAG--QVQRRLGIFPASYVA 84
           69***********************54444578*******..7************97 PP

Organism

Mus musculus

Functional Description
(View)

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity).

Protein Sequence
(Fasta)

MALPVAEGTA DTPLSPARDD SGSTSSGMWA ALYDYEARGE DELSLRRGQL VEVLSQDAAV 60
SGDEGWWAGQ VQRRLGIFPA SYVAPCGPVP PPAPPPPRPC SPVHVDFERL ELKELIGAGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACCGCCA CCGGTTGTCC GCGCTAGCGG CTGCGGGGAA GAACTAGCCA AACTGGAGGC 60
AGAGCAGAGG TCAGAGCCCC CGGGCAGTGG TCGTAACCTC TGTAGTCCTG CTCCAGCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR016231--MLK1/MLK2/MLK4
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0007257--P:activation of JUN kinase activity

KEGG

mmu:234878

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005356	Anolis carolinensis	54.71	0.00e+00	922.00
IUUC-Bta-012631	Bos taurus	62.36	0.00e+00	933.00
IUUC-Cja-019307	Callithrix jacchus	65.19	0.00e+00	1034.00
IUUC-Cfa-020962	Canis familiaris	63.83	0.00e+00	964.00
IUUC-Cpo-021521	Cavia porcellus	82.90	0.00e+00	895.00
IUUC-Csa-023781	Chlorocebus sabaeus	65.87	0.00e+00	1012.00
IUUC-Dre-027645	Danio rerio	66.52	0.00e+00	827.00
IUUC-Gmo-039264	Gadus morhua	62.80	0.00e+00	793.00
IUUC-Gga-040976	Gallus gallus	58.33	0.00e+00	1010.00
IUUC-Ggo-044536	Gorilla gorilla	69.26	0.00e+00	1068.00
IUUC-Hsa-045686	Homo sapiens	67.60	0.00e+00	1017.00
IUUC-Mcc-055881	Macaca mulatta	65.16	0.00e+00	1000.00
IUUC-Mdo-062770	Monodelphis domestica	73.41	0.00e+00	970.00
IUUC-Ont-071825	Oreochromis niloticus	63.12	0.00e+00	825.00
IUUC-Ocu-074362	Oryctolagus cuniculus	67.91	0.00e+00	976.00
IUUC-Oga-087967	Otolemur garnettii	67.84	0.00e+00	1049.00
IUUC-Pfo-096763	Poecilia formosa	68.95	0.00e+00	812.00
IUUC-Rno-105010	Rattus norvegicus	88.92	0.00e+00	1393.00
IUUC-Ssc-115831	Sus scrofa	74.58	0.00e+00	913.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence