iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.30e-44	147.9	192	222
UBD/Beta-Prp	3.90e-61	208.5	13	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkgh 93
           +h++s++  +++ p ++lla+ + d++i++w ++  +    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl+gh
   Q: 13   AHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWicKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTLEGH 104
           688999999999*********************9877654566689******************************99999*********** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llrtltgghtd 181
           e++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ + ++  +  tl+g h++
   Q: 105  ENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDwvCCATLEG-HES 195
           ******************************9987776566*********************************9977754499****9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklw 207
            v sl+fd++g++l+s+s+d+tv++w
   Q: 196  TVWSLAFDPSGQRLASCSDDRTVRIW 221
           ************************** PP

Organism

Homo sapiens

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGCCGAG GTGAGGGGAG CGACTACAAC TCCCAGAGGG TATGGCGGCC GCAGCAGTGG 60
GCAGTTGAGT TTCCGGGGCG ACCCAGGTCC TCCGGCGGAA GCGGGAGCCT CTGTCGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly
GO:0008284--P:positive regulation of cell proliferation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

hsa:9391

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	48.00	1.00e-66	248.00
IUUC-Aml-001317	Ailuropoda melanoleuca	96.76	0.00e+00	634.00
IUUC-Atr-003029	Amborella trichopoda	51.91	3.00e-94	338.00
IUUC-Apl-004042	Anas platyrhynchos	76.52	1.00e-56	211.00
IUUC-Aly-006458	Arabidopsis lyrata	48.41	7.00e-86	310.00
IUUC-Ath-006671	Arabidopsis thaliana	48.41	2.00e-85	309.00
IUUC-Ago-007820	Ashbya gossypii	40.59	7.00e-60	224.00
IUUC-Acl-008042	Aspergillus clavatus	31.57	4.00e-50	192.00
IUUC-Afl-008639	Aspergillus flavus	32.38	6.00e-53	201.00
IUUC-Afu-008899	Aspergillus fumigatus	35.51	5.00e-49	188.00
IUUC-Ani-009453	Aspergillus nidulans	32.38	5.00e-51	195.00
IUUC-Ang-009758	Aspergillus niger	34.66	3.00e-51	196.00
IUUC-Aor-010212	Aspergillus oryzae	32.38	6.00e-53	201.00
IUUC-Ate-010314	Aspergillus terreus	32.37	2.00e-52	200.00
IUUC-Ame-010676	Astyanax mexicanus	77.25	2.00e-157	548.00
IUUC-Bgr-012095	Blumeria graminis	30.46	2.00e-38	153.00
IUUC-Bta-012884	Bos taurus	93.51	6.00e-177	613.00
IUUC-Bci-013622	Botrytis cinerea	32.56	1.00e-37	150.00
IUUC-Bdi-014614	Brachypodium distachyon	48.82	1.00e-85	310.00
IUUC-Bol-016439	Brassica oleracea	47.35	4.00e-83	301.00
IUUC-Bra-016830	Brassica rapa	46.61	5.00e-82	297.00
IUUC-Cel-018709	Caenorhabditis elegans	39.76	3.00e-63	235.00
IUUC-Cja-019822	Callithrix jacchus	98.53	0.00e+00	647.00
IUUC-Cfa-020823	Canis familiaris	97.35	0.00e+00	638.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	47.41	9.00e-81	293.00
IUUC-Csa-023754	Chlorocebus sabaeus	100.00	0.00e+00	654.00
IUUC-Cin-025395	Ciona intestinalis	57.31	2.00e-116	411.00
IUUC-Csv-025943	Ciona savignyi	55.26	5.00e-112	397.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	33.67	2.00e-36	147.00
IUUC-Cne-026939	Cryptococcus neoformans	32.59	2.00e-49	189.00
IUUC-Cme-027239	Cyanidioschyzon merolae	40.93	2.00e-44	173.00
IUUC-Dre-028172	Danio rerio	76.95	1.00e-155	542.00
IUUC-Dno-029472	Dasypus novemcinctus	95.56	1.00e-153	535.00
IUUC-Dor-031134	Dipodomys ordii	85.25	5.00e-154	536.00
IUUC-Dse-031535	Dothistroma septosporum	30.09	4.00e-47	182.00
IUUC-Dme-032020	Drosophila melanogaster	59.09	7.00e-118	416.00
IUUC-Eca-033700	Equus caballus	97.94	0.00e+00	642.00
IUUC-Eeu-035010	Erinaceus europaeus	94.40	1.00e-177	615.00
IUUC-Fca-036309	Felis catus	88.82	2.00e-172	598.00
IUUC-Fal-037243	Ficedula albicollis	73.95	3.00e-86	310.00
IUUC-Fox-038058	Fusarium oxysporum	32.82	2.00e-43	171.00
IUUC-Fso-038459	Fusarium solani	35.43	2.00e-39	156.00
IUUC-Gmo-039375	Gadus morhua	75.52	1.00e-140	492.00
IUUC-Ggr-040002	Gaeumannomyces graminis	35.67	1.00e-40	160.00
IUUC-Gga-040294	Gallus gallus	77.98	6.00e-130	456.00
IUUC-Gac-042499	Gasterosteus aculeatus	74.78	5.00e-139	487.00
IUUC-Gma-043543	Glycine max	48.97	3.00e-87	315.00
IUUC-Ggo-045181	Gorilla gorilla	100.00	0.00e+00	654.00
IUUC-Hvu-047341	Hordeum vulgare	57.45	9.00e-56	209.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	97.94	0.00e+00	642.00
IUUC-Kpa-049353	Komagataella pastoris	37.39	6.00e-57	214.00
IUUC-Lch-049763	Latimeria chalumnae	80.24	2.00e-160	558.00
IUUC-Lpe-051500	Leersia perrieri	44.74	2.00e-81	296.00
IUUC-Loc-052021	Lepisosteus oculatus	80.54	2.00e-153	535.00
IUUC-Lma-053331	Leptosphaeria maculans	35.00	1.00e-55	211.00
IUUC-Laf-054558	Loxodonta africana	95.28	2.00e-180	624.00
IUUC-Mcc-055374	Macaca mulatta	99.71	0.00e+00	651.00
IUUC-Meu-056042	Macropus eugenii	77.24	3.00e-112	397.00
IUUC-Mor-057187	Magnaporthe oryzae	35.48	1.00e-38	154.00
IUUC-Mtr-058072	Medicago truncatula	48.51	1.00e-86	313.00
IUUC-Mla-059108	Melampsora laricipopulina	31.59	1.00e-51	197.00
IUUC-Mga-059370	Meleagris gallopavo	63.93	3.00e-101	361.00
IUUC-Mvi-060495	Microbotryum violaceum	36.81	7.00e-58	218.00
IUUC-Mmr-060902	Microcebus murinus	97.64	0.00e+00	638.00
IUUC-Mdo-062510	Monodelphis domestica	92.92	3.00e-171	594.00
IUUC-Mmu-063575	Mus musculus	94.99	0.00e+00	625.00
IUUC-Mac-065322	Musa acuminata	50.74	2.00e-91	328.00
IUUC-Mpu-065925	Mustela putorius furo	96.76	0.00e+00	634.00
IUUC-Mlu-067755	Myotis lucifugus	96.76	0.00e+00	632.00
IUUC-Nfi-068327	Neosartorya fischeri	31.22	9.00e-49	187.00
IUUC-Ncr-068845	Neurospora crassa	33.23	7.00e-33	135.00
IUUC-Nle-069406	Nomascus leucogenys	97.35	0.00e+00	633.00
IUUC-Opr-070416	Ochotona princeps	75.81	6.00e-133	467.00
IUUC-Ont-071936	Oreochromis niloticus	75.67	2.00e-142	498.00
IUUC-Oan-073452	Ornithorhynchus anatinus	92.73	3.00e-76	277.00
IUUC-Ocu-074791	Oryctolagus cuniculus	95.87	0.00e+00	630.00
IUUC-Oba-075636	Oryza barthii	49.55	7.00e-89	320.00
IUUC-Obr-076742	Oryza brachyantha	48.60	3.00e-77	281.00
IUUC-Ogl-077766	Oryza glaberrima	49.55	7.00e-89	320.00
IUUC-Ogu-079039	Oryza glumaepatula	49.55	3.00e-89	321.00
IUUC-Oin-079315	Oryza indica	49.32	6.00e-78	284.00
IUUC-Olo-080669	Oryza longistaminata	44.01	6.00e-81	294.00
IUUC-Ome-081490	Oryza meridionalis	49.55	5.00e-89	320.00
IUUC-Oni-082572	Oryza nivara	49.55	7.00e-89	320.00
IUUC-Opu-083732	Oryza punctata	49.70	6.00e-89	320.00
IUUC-Oru-084763	Oryza rufipogon	49.55	7.00e-89	320.00
IUUC-Osa-085372	Oryza sativa	49.55	7.00e-89	320.00
IUUC-Ola-087379	Oryzias latipes	73.53	1.00e-138	485.00
IUUC-Olu-087801	Ostreococcus lucimarinus	36.01	1.00e-44	173.00
IUUC-Oga-089076	Otolemur garnettii	97.05	0.00e+00	635.00
IUUC-Oar-090022	Ovis aries	93.22	4.00e-176	610.00
IUUC-Ptr-090809	Pan troglodytes	100.00	0.00e+00	654.00
IUUC-Pan-091685	Papio anubis	100.00	0.00e+00	661.00
IUUC-Psi-093046	Pelodiscus sinensis	88.13	1.00e-168	585.00
IUUC-Pma-094181	Petromyzon marinus	63.80	8.00e-132	462.00
IUUC-Pno-094882	Phaeosphaeria nodorum	35.19	7.00e-56	211.00
IUUC-Ppa-095172	Physcomitrella patens	47.67	5.00e-86	311.00
IUUC-Pfo-096396	Poecilia formosa	72.11	8.00e-139	486.00
IUUC-Pab-098427	Pongo abelii	99.41	0.00e+00	646.00
IUUC-Pop-100016	Populus trichocarpa	51.63	2.00e-90	326.00
IUUC-Pca-101048	Procavia capensis	95.58	0.00e+00	625.00
IUUC-Ppe-102050	Prunus persica	47.71	2.00e-86	312.00
IUUC-Pva-103117	Pteropus vampyrus	96.17	0.00e+00	630.00
IUUC-Pgr-103307	Puccinia graminis	34.25	1.00e-56	214.00
IUUC-Ptt-103938	Puccinia triticina	38.06	6.00e-49	187.00
IUUC-Pte-104315	Pyrenophora teres	34.05	1.00e-56	214.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	33.33	1.00e-55	210.00
IUUC-Rno-105523	Rattus norvegicus	94.40	7.00e-180	622.00
IUUC-Sce-106297	Saccharomyces cerevisiae	42.27	3.00e-65	241.00
IUUC-Sha-106981	Sarcophilus harrisii	92.15	6.00e-143	499.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	39.31	7.00e-56	211.00
IUUC-Spo-108214	Schizosaccharomyces pombe	41.16	1.00e-57	217.00
IUUC-Smo-109034	Selaginella moellendorffii	45.33	5.00e-82	297.00
IUUC-Sit-110663	Setaria italica	50.44	4.00e-90	324.00
IUUC-Sly-110898	Solanum lycopersicum	47.38	1.00e-82	300.00
IUUC-Stu-112647	Solanum tuberosum	50.37	5.00e-70	257.00
IUUC-Sbi-114288	Sorghum bicolor	48.09	8.00e-86	310.00
IUUC-Sre-115065	Sporisorium reilianum	43.18	2.00e-75	276.00
IUUC-Ssc-115960	Sus scrofa	89.61	2.00e-179	621.00
IUUC-Tru-118382	Takifugu rubripes	71.22	2.00e-147	514.00
IUUC-Tsy-119585	Tarsius syrichta	89.09	3.00e-164	571.00
IUUC-Tni-120133	Tetraodon nigroviridis	74.85	3.00e-143	501.00
IUUC-Tca-121167	Theobroma cacao	49.26	1.00e-81	296.00
IUUC-Tre-122119	Trichoderma reesei	29.10	3.00e-40	159.00
IUUC-Tvi-122407	Trichoderma virens	32.84	7.00e-40	158.00
IUUC-Tae-125748	Triticum aestivum	48.09	4.00e-82	298.00
IUUC-Tur-126682	Triticum urartu	48.52	3.00e-67	248.00
IUUC-Tme-127095	Tuber melanosporum	35.95	7.00e-61	228.00
IUUC-Tbe-128004	Tupaia belangeri	97.05	0.00e+00	637.00
IUUC-Ttr-129284	Tursiops truncatus	91.52	1.00e-170	592.00
IUUC-Uma-129527	Ustilago maydis	42.78	3.00e-74	272.00
IUUC-Vda-129854	Verticillium dahliae	31.52	1.00e-37	150.00
IUUC-Vpa-130681	Vicugna pacos	97.41	9.00e-50	190.00
IUUC-Vvi-131004	Vitis vinifera	53.45	1.00e-87	316.00
IUUC-Xtr-131928	Xenopus tropicalis	81.31	3.00e-155	541.00
IUUC-Xma-134290	Xiphophorus maculatus	70.92	2.00e-135	474.00
IUUC-Yli-134364	Yarrowia lipolytica	43.73	2.00e-67	249.00
IUUC-Zma-135658	Zea mays	49.55	9.00e-87	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence