iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mor-057292

Ensembl Protein ID

MGG_17909T0

UniProt Accession

Q51LD2; A4RBA2; G4NLC0; Q2KFF3; ATG3_MAGO7

Genbank Protein ID

EAQ71326.1; EHA46004.1

Protein Name

Autophagy-related protein 3; Autophagy-related E2-like conjugation enzyme ATG3

Genbank Nucleotide ID

CM000230; CM001237

Gene Name

ATG3; MGCH7_ch7g733; MGG_02959

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MGG_17909	MGG_17909T0	MGG_17909T0

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E2/Autophagy_C	36.72	2.00e-31	133.00	IUUC-Ath-006802
E2/Autophagy_C	30.61	3.00e-36	150.00	IUUC-Hsa-046449
E2/Autophagy_C	37.36	1.00e-53	205.00	IUUC-Sce-106172

Active Site

Position(s)	Description	Evidence
244	Glycyl thioester intermediate	{ECO:0000250}

Organism

Magnaporthe oryzae

Functional Description
(View)

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).

Protein Sequence
(Fasta)

MNSLYSVVNT LRDRYAPVSH TSTFRQTGEI TPEEFVAAGD YLVFKFPTWS WGDADSESRR 60
ASHLPPGKQF LVTRNVPCNR RLNENFAGDA GLEEAVVDDG DEFKGSKGDD DGWLRTGGLS 120

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Nucleotide Sequence
(Fasta)

GTCAAAGCCT CCTTAGCCTG GTACCTTGGC TTGCTTTGAA CACAGCAACT TGGTTTTGCC 60
TCGAACCATC GAAGTTACAG GCTTCATTCA TCTTTTTCTC AAACCGTTAC CATACTAACT 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007135--Autophagy-rel_prot_3
IPR019461--Autophagy-rel_prot_3_C
IPR007134--Autophagy-rel_prot_3_N

Pfam

PF03987--Autophagy_act_C
PF10381--Autophagy_C
PF03986--Autophagy_N

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0044805--P:late nucleophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0006612--P:protein targeting to membrane

KEGG

mgr:MGG_17909

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001111	Aegilops tauschii	35.02	1.00e-31	128.00
IUUC-Aml-002081	Ailuropoda melanoleuca	32.35	2.00e-40	157.00
IUUC-Atr-002712	Amborella trichopoda	34.42	8.00e-33	132.00
IUUC-Apl-003956	Anas platyrhynchos	25.36	8.00e-20	89.00
IUUC-Aca-004578	Anolis carolinensis	31.28	2.00e-39	154.00
IUUC-Aly-005823	Arabidopsis lyrata	37.98	6.00e-35	139.00
IUUC-Ath-006802	Arabidopsis thaliana	37.98	3.00e-35	140.00
IUUC-Ago-007855	Ashbya gossypii	37.39	2.00e-52	197.00
IUUC-Acl-008147	Aspergillus clavatus	60.00	4.00e-104	369.00
IUUC-Afl-008483	Aspergillus flavus	63.54	9.00e-105	371.00
IUUC-Afu-008818	Aspergillus fumigatus	62.78	4.00e-116	409.00
IUUC-Ani-009481	Aspergillus nidulans	61.25	3.00e-102	363.00
IUUC-Ang-009800	Aspergillus niger	58.95	8.00e-103	364.00
IUUC-Aor-010150	Aspergillus oryzae	63.54	9.00e-105	371.00
IUUC-Ate-010545	Aspergillus terreus	58.30	4.00e-61	226.00
IUUC-Ame-011793	Astyanax mexicanus	30.40	1.00e-36	145.00
IUUC-Bgr-012167	Blumeria graminis	62.50	1.00e-110	390.00
IUUC-Bta-012695	Bos taurus	32.09	5.00e-40	156.00
IUUC-Bci-013972	Botrytis cinerea	66.30	4.00e-100	356.00
IUUC-Bdi-014756	Brachypodium distachyon	36.92	1.00e-32	131.00
IUUC-Bol-015091	Brassica oleracea	37.07	7.00e-34	135.00
IUUC-Bra-017220	Brassica rapa	37.94	8.00e-35	139.00
IUUC-Cel-018143	Caenorhabditis elegans	31.49	2.00e-41	161.00
IUUC-Cja-018991	Callithrix jacchus	31.47	7.00e-40	155.00
IUUC-Cfa-020070	Canis familiaris	32.59	2.00e-39	154.00
IUUC-Cpo-021860	Cavia porcellus	31.82	2.00e-40	157.00
IUUC-Cre-022948	Chlamydomonas reinhardtii	30.69	3.00e-36	143.00
IUUC-Csa-023881	Chlorocebus sabaeus	31.55	5.00e-40	156.00
IUUC-Cho-024852	Choloepus hoffmanni	33.88	2.00e-20	91.70
IUUC-Cin-025787	Ciona intestinalis	46.74	2.00e-18	84.70
IUUC-Csv-026369	Ciona savignyi	33.33	4.00e-20	90.10
IUUC-Cgl-026680	Colletotrichum gloeosporioides	72.08	5.00e-123	432.00
IUUC-Cne-026905	Cryptococcus neoformans	60.56	2.00e-20	92.00
IUUC-Dre-028811	Danio rerio	31.37	1.00e-37	148.00
IUUC-Dno-030081	Dasypus novemcinctus	31.12	8.00e-38	149.00
IUUC-Dor-030183	Dipodomys ordii	40.83	1.00e-20	91.70
IUUC-Dse-031539	Dothistroma septosporum	56.02	9.00e-60	221.00
IUUC-Dme-031805	Drosophila melanogaster	48.86	1.00e-19	88.60
IUUC-Ete-033171	Echinops telfairi	32.53	9.00e-41	158.00
IUUC-Eca-034083	Equus caballus	32.09	5.00e-40	156.00
IUUC-Eeu-034804	Erinaceus europaeus	31.28	2.00e-38	150.00
IUUC-Fca-036289	Felis catus	32.09	3.00e-40	157.00
IUUC-Fal-037060	Ficedula albicollis	30.77	2.00e-38	150.00
IUUC-Fox-038051	Fusarium oxysporum	77.49	2.00e-136	477.00
IUUC-Fso-038124	Fusarium solani	75.50	2.00e-119	419.00
IUUC-Gmo-039538	Gadus morhua	33.61	5.00e-39	152.00
IUUC-Ggr-039880	Gaeumannomyces graminis	82.69	7.00e-158	548.00
IUUC-Gga-041108	Gallus gallus	30.83	2.00e-38	150.00
IUUC-Gac-041558	Gasterosteus aculeatus	31.87	1.00e-37	147.00
IUUC-Gma-043969	Glycine max	34.77	3.00e-32	130.00
IUUC-Ggo-045071	Gorilla gorilla	31.55	8.00e-40	155.00
IUUC-Hsa-046449	Homo sapiens	31.55	8.00e-40	155.00
IUUC-Hvu-047451	Hordeum vulgare	31.14	1.00e-33	135.00
IUUC-Itr-048360	Ictidomys tridecemlineatus	31.55	1.00e-39	155.00
IUUC-Kpa-049096	Komagataella pastoris	41.45	3.00e-60	223.00
IUUC-Lch-049726	Latimeria chalumnae	31.28	2.00e-39	154.00
IUUC-Lpe-050734	Leersia perrieri	33.43	8.00e-39	152.00
IUUC-Loc-051983	Lepisosteus oculatus	31.83	5.00e-38	149.00
IUUC-Lma-053038	Leptosphaeria maculans	61.30	8.00e-103	365.00
IUUC-Laf-054510	Loxodonta africana	31.49	3.00e-38	150.00
IUUC-Mcc-054792	Macaca mulatta	31.55	5.00e-40	156.00
IUUC-Meu-055965	Macropus eugenii	32.58	8.00e-23	99.40
IUUC-Mtr-058282	Medicago truncatula	35.91	4.00e-34	136.00
IUUC-Mla-059144	Melampsora laricipopulina	40.91	4.00e-27	113.00
IUUC-Mga-059509	Meleagris gallopavo	30.21	3.00e-36	143.00
IUUC-Mvi-060281	Microbotryum violaceum	38.86	3.00e-25	107.00
IUUC-Mmr-061788	Microcebus murinus	32.09	4.00e-40	156.00
IUUC-Mdo-062922	Monodelphis domestica	32.27	1.00e-38	151.00
IUUC-Mmu-064249	Mus musculus	31.82	1.00e-38	151.00
IUUC-Mac-064474	Musa acuminata	30.26	9.00e-35	138.00
IUUC-Mpu-065717	Mustela putorius furo	31.55	9.00e-40	155.00
IUUC-Mlu-067151	Myotis lucifugus	31.81	3.00e-34	136.00
IUUC-Nfi-068551	Neosartorya fischeri	61.22	1.00e-115	407.00
IUUC-Ncr-068846	Neurospora crassa	68.26	5.00e-120	422.00
IUUC-Nle-069790	Nomascus leucogenys	31.55	8.00e-40	155.00
IUUC-Ont-072517	Oreochromis niloticus	31.37	1.00e-38	151.00
IUUC-Oan-073285	Ornithorhynchus anatinus	34.44	4.00e-20	89.70
IUUC-Ocu-074695	Oryctolagus cuniculus	31.28	3.00e-39	153.00
IUUC-Oba-075515	Oryza barthii	38.49	3.00e-37	147.00
IUUC-Obr-076787	Oryza brachyantha	37.69	2.00e-38	150.00
IUUC-Ogl-077440	Oryza glaberrima	37.86	1.00e-38	151.00
IUUC-Ogu-078037	Oryza glumaepatula	38.08	8.00e-38	149.00
IUUC-Oin-079452	Oryza indica	38.49	3.00e-37	147.00
IUUC-Olo-080450	Oryza longistaminata	38.93	1.00e-36	144.00
IUUC-Ome-081514	Oryza meridionalis	38.87	3.00e-38	150.00
IUUC-Oni-082677	Oryza nivara	38.49	3.00e-37	147.00
IUUC-Opu-083925	Oryza punctata	39.46	2.00e-38	150.00
IUUC-Oru-084828	Oryza rufipogon	38.65	7.00e-36	142.00
IUUC-Osa-085937	Oryza sativa	38.49	3.00e-37	147.00
IUUC-Ola-086559	Oryzias latipes	35.24	2.00e-23	100.00
IUUC-Olu-087766	Ostreococcus lucimarinus	31.04	2.00e-35	140.00
IUUC-Oga-087983	Otolemur garnettii	31.20	2.00e-38	150.00
IUUC-Oar-089281	Ovis aries	32.35	5.00e-40	156.00
IUUC-Ptr-090983	Pan troglodytes	31.55	8.00e-40	155.00
IUUC-Pan-092457	Papio anubis	31.02	1.00e-39	154.00
IUUC-Psi-094046	Pelodiscus sinensis	32.49	2.00e-36	144.00
IUUC-Pno-094925	Phaeosphaeria nodorum	59.94	1.00e-104	371.00
IUUC-Ppa-095487	Physcomitrella patens	36.11	3.00e-35	140.00
IUUC-Pfo-096968	Poecilia formosa	31.38	5.00e-38	149.00
IUUC-Pab-098621	Pongo abelii	31.55	1.00e-38	151.00
IUUC-Pop-100007	Populus trichocarpa	36.43	1.00e-32	132.00
IUUC-Pca-100590	Procavia capensis	33.88	2.00e-20	91.30
IUUC-Ppe-101657	Prunus persica	37.85	8.00e-34	135.00
IUUC-Pva-102446	Pteropus vampyrus	31.28	5.00e-40	156.00
IUUC-Pgr-103604	Puccinia graminis	48.86	3.00e-21	94.40
IUUC-Ptt-103941	Puccinia triticina	34.85	5.00e-26	110.00
IUUC-Pte-104252	Pyrenophora teres	60.34	1.00e-104	370.00
IUUC-Pyt-104556	Pyrenophora triticirepentis	60.45	6.00e-104	368.00
IUUC-Rno-106025	Rattus norvegicus	32.35	2.00e-39	154.00
IUUC-Sce-106172	Saccharomyces cerevisiae	37.64	1.00e-54	204.00
IUUC-Sha-106858	Sarcophilus harrisii	30.83	1.00e-38	151.00
IUUC-Sja-107905	Schizosaccharomyces japonicus	33.33	1.00e-21	94.70
IUUC-Spo-108185	Schizosaccharomyces pombe	53.85	8.00e-17	79.00
IUUC-Smo-108883	Selaginella moellendorffii	31.79	2.00e-33	134.00
IUUC-Sit-110512	Setaria italica	50.63	1.00e-17	82.40
IUUC-Sly-111238	Solanum lycopersicum	31.62	2.00e-37	147.00
IUUC-Stu-112441	Solanum tuberosum	31.62	8.00e-38	149.00
IUUC-Sar-113039	Sorex araneus	33.33	4.00e-20	89.70
IUUC-Sbi-113776	Sorghum bicolor	35.13	8.00e-32	129.00
IUUC-Sre-115074	Sporisorium reilianum	41.75	6.00e-18	83.60
IUUC-Ssc-115262	Sus scrofa	32.62	9.00e-40	155.00
IUUC-Tgu-116790	Taeniopygia guttata	30.48	3.00e-38	150.00
IUUC-Tru-118160	Takifugu rubripes	32.22	2.00e-36	144.00
IUUC-Tsy-119145	Tarsius syrichta	29.18	3.00e-14	70.90
IUUC-Tni-119937	Tetraodon nigroviridis	28.57	2.00e-30	124.00
IUUC-Tca-121323	Theobroma cacao	37.11	2.00e-35	141.00
IUUC-Tre-121993	Trichoderma reesei	69.19	2.00e-112	396.00
IUUC-Tvi-122332	Trichoderma virens	70.54	2.00e-114	404.00
IUUC-Tae-123478	Triticum aestivum	32.00	3.00e-35	140.00
IUUC-Tur-126679	Triticum urartu	31.14	5.00e-35	139.00
IUUC-Tme-127159	Tuber melanosporum	39.16	5.00e-20	89.40
IUUC-Ttr-128261	Tursiops truncatus	32.95	1.00e-38	151.00
IUUC-Uma-129572	Ustilago maydis	35.89	6.00e-26	110.00
IUUC-Vda-129966	Verticillium dahliae	72.86	2.00e-137	479.00
IUUC-Vpa-130698	Vicugna pacos	28.00	3.00e-27	114.00
IUUC-Xtr-132878	Xenopus tropicalis	30.61	8.00e-40	155.00
IUUC-Xma-134017	Xiphophorus maculatus	31.22	2.00e-37	147.00
IUUC-Yli-134373	Yarrowia lipolytica	40.11	9.00e-56	208.00
IUUC-Zma-135222	Zea mays	51.90	6.00e-18	83.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence