iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009248

Ensembl Protein ID

CADANIAP00008406

UniProt Accession

Q5BCH0; C8VP62; ATG12_EMENI

Genbank Protein ID

EAA64046.1; CBF85511.1

Protein Name

Ubiquitin-like protein ATG12; Autophagy-related protein 12

Genbank Nucleotide ID

AACD01000027; BN001307

Gene Name

ANIA_01760; atg12; AN1760

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00008406	CADANIAT00008406	CADANIAP00008406

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG12	27.59	5.00e-10	61.60	IUUC-Hsa-046903

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Aspergillus nidulans

Functional Description
(View)

Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MSSPSSRISS INNSPNPNLR KPSSRRESLD QPSNAQNAPI PDDEHGADLP LTMSASVVLT 60
SLPRDAHQAL ADAEAIDTGK VTVRFQPLAS APILKNRVFK ISASQKFETV VNFLRKKLNC 120

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Nucleotide Sequence
(Fasta)

ATGAGCTCTC CTTCTTCACG TATTTCCTCA ATTAATAACT CTCCGAACCC AAACTTGCGA 60
AAACCATCGA GCCGGAGGGA AAGTTTAGAC CAGCCATCCA ACGCACAGAA TGCGCCTATA 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom

Pfam

PF04110--APG12

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG

ani:AN1760.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001177	Aegilops tauschii	41.38	2.00e-14	68.20
IUUC-Aml-002116	Ailuropoda melanoleuca	28.74	4.00e-12	62.00
IUUC-Atr-002615	Amborella trichopoda	40.23	1.00e-13	66.20
IUUC-Apl-003753	Anas platyrhynchos	47.37	8.00e-07	42.70
IUUC-Aca-005231	Anolis carolinensis	28.74	1.00e-08	50.10
IUUC-Aly-006172	Arabidopsis lyrata	42.53	1.00e-14	69.30
IUUC-Ath-006953	Arabidopsis thaliana	42.53	9.00e-16	72.80
IUUC-Ago-007970	Ashbya gossypii	43.68	2.00e-13	67.40
IUUC-Acl-008072	Aspergillus clavatus	91.23	3.00e-59	217.00
IUUC-Afl-008725	Aspergillus flavus	85.71	4.00e-74	268.00
IUUC-Afu-008967	Aspergillus fumigatus	85.14	4.00e-71	258.00
IUUC-Ang-009684	Aspergillus niger	79.74	6.00e-69	251.00
IUUC-Aor-009947	Aspergillus oryzae	85.71	4.00e-74	268.00
IUUC-Ame-011656	Astyanax mexicanus	27.17	2.00e-10	56.20
IUUC-Bgr-012174	Blumeria graminis	57.30	1.00e-24	103.00
IUUC-Bta-012483	Bos taurus	27.59	8.00e-12	60.80
IUUC-Bci-013755	Botrytis cinerea	55.74	2.00e-31	125.00
IUUC-Bdi-014156	Brachypodium distachyon	41.84	2.00e-15	72.00
IUUC-Bol-015683	Brassica oleracea	42.53	6.00e-16	73.60
IUUC-Bra-016802	Brassica rapa	41.38	8.00e-15	69.70
IUUC-Cel-018242	Caenorhabditis elegans	36.26	3.00e-12	61.60
IUUC-Cja-019514	Callithrix jacchus	27.59	1.00e-11	60.80
IUUC-Cfa-020748	Canis familiaris	28.74	4.00e-12	62.00
IUUC-Cpo-021965	Cavia porcellus	28.74	6.00e-12	61.60
IUUC-Cre-023009	Chlamydomonas reinhardtii	36.96	3.00e-12	61.20
IUUC-Csa-023494	Chlorocebus sabaeus	27.59	5.00e-12	61.60
IUUC-Cho-024631	Choloepus hoffmanni	27.59	9.00e-12	61.60
IUUC-Cin-025609	Ciona intestinalis	43.68	4.00e-20	87.40
IUUC-Cgl-026722	Colletotrichum gloeosporioides	50.00	2.00e-33	132.00
IUUC-Dre-027479	Danio rerio	28.57	6.00e-12	60.80
IUUC-Dno-029693	Dasypus novemcinctus	44.74	7.00e-06	41.20
IUUC-Dse-031440	Dothistroma septosporum	54.61	9.00e-42	160.00
IUUC-Dme-031892	Drosophila melanogaster	25.56	1.00e-09	53.10
IUUC-Ete-032550	Echinops telfairi	27.38	3.00e-11	58.50
IUUC-Eca-033553	Equus caballus	27.59	5.00e-12	61.60
IUUC-Fca-036524	Felis catus	28.74	1.00e-10	57.00
IUUC-Fal-036942	Ficedula albicollis	30.23	6.00e-12	60.10
IUUC-Fox-037753	Fusarium oxysporum	65.00	1.00e-38	150.00
IUUC-Gmo-039498	Gadus morhua	27.59	3.00e-10	55.50
IUUC-Ggr-039852	Gaeumannomyces graminis	60.33	3.00e-30	122.00
IUUC-Gga-041263	Gallus gallus	28.74	5.00e-12	61.60
IUUC-Gac-042346	Gasterosteus aculeatus	29.76	2.00e-10	55.80
IUUC-Gma-042896	Glycine max	40.23	2.00e-13	65.10
IUUC-Ggo-045601	Gorilla gorilla	27.59	1.00e-11	60.80
IUUC-Hsa-046903	Homo sapiens	27.59	6.00e-12	61.20
IUUC-Hvu-047239	Hordeum vulgare	41.24	2.00e-14	68.90
IUUC-Itr-048445	Ictidomys tridecemlineatus	27.59	7.00e-12	61.20
IUUC-Kpa-049355	Komagataella pastoris	31.75	2.00e-14	69.30
IUUC-Lch-050619	Latimeria chalumnae	31.03	9.00e-13	63.90
IUUC-Loc-052102	Lepisosteus oculatus	25.45	4.00e-03	30.80
IUUC-Lma-053299	Leptosphaeria maculans	55.65	3.00e-32	128.00
IUUC-Laf-054205	Loxodonta africana	27.59	4.00e-12	62.00
IUUC-Meu-056804	Macropus eugenii	28.74	6.00e-12	61.20
IUUC-Mor-057052	Magnaporthe oryzae	58.12	8.00e-30	121.00
IUUC-Mtr-057961	Medicago truncatula	41.38	5.00e-14	67.00
IUUC-Mla-059045	Melampsora laricipopulina	49.02	2.00e-24	102.00
IUUC-Mvi-060360	Microbotryum violaceum	49.00	1.00e-23	99.80
IUUC-Mmr-061654	Microcebus murinus	27.59	5.00e-12	61.20
IUUC-Mdo-062649	Monodelphis domestica	27.59	4.00e-12	62.00
IUUC-Mmu-064105	Mus musculus	27.59	7.00e-12	61.20
IUUC-Mac-065532	Musa acuminata	42.53	1.00e-14	69.30
IUUC-Mpu-066269	Mustela putorius furo	28.74	2.00e-12	62.80
IUUC-Mlu-067631	Myotis lucifugus	27.59	5.00e-12	62.00
IUUC-Nfi-068468	Neosartorya fischeri	92.11	8.00e-60	219.00
IUUC-Ncr-068750	Neurospora crassa	52.90	8.00e-39	150.00
IUUC-Nle-069483	Nomascus leucogenys	27.59	5.00e-12	62.40
IUUC-Opr-070936	Ochotona princeps	27.59	7.00e-12	61.60
IUUC-Obr-076322	Oryza brachyantha	39.13	6.00e-15	70.10
IUUC-Ogl-077226	Oryza glaberrima	38.55	4.00e-13	64.30
IUUC-Oin-079220	Oryza indica	37.31	2.00e-09	52.80
IUUC-Olo-080688	Oryza longistaminata	38.55	4.00e-13	64.30
IUUC-Ome-081265	Oryza meridionalis	38.55	4.00e-13	64.30
IUUC-Oru-084342	Oryza rufipogon	40.23	6.00e-14	68.90
IUUC-Osa-086212	Oryza sativa	38.55	4.00e-13	64.30
IUUC-Ola-087277	Oryzias latipes	27.78	6.00e-11	57.40
IUUC-Olu-087780	Ostreococcus lucimarinus	32.97	3.00e-08	48.10
IUUC-Oga-088175	Otolemur garnettii	27.59	6.00e-12	61.20
IUUC-Oar-089477	Ovis aries	27.59	1.00e-11	60.80
IUUC-Ptr-091129	Pan troglodytes	27.59	1.00e-11	61.20
IUUC-Psi-093351	Pelodiscus sinensis	27.59	1.00e-11	60.50
IUUC-Pno-094948	Phaeosphaeria nodorum	56.64	5.00e-34	134.00
IUUC-Ppa-095788	Physcomitrella patens	40.23	7.00e-15	70.10
IUUC-Pfo-096993	Poecilia formosa	25.53	6.00e-10	54.30
IUUC-Pab-098502	Pongo abelii	27.59	9.00e-12	61.20
IUUC-Pop-098819	Populus trichocarpa	37.93	2.00e-13	65.50
IUUC-Pca-100144	Procavia capensis	16.09	4.00e-03	32.70
IUUC-Ppe-101560	Prunus persica	40.00	2.00e-12	61.60
IUUC-Pva-102810	Pteropus vampyrus	25.37	7.00e-07	45.10
IUUC-Pgr-103531	Puccinia graminis	46.49	6.00e-25	103.00
IUUC-Ptt-103753	Puccinia triticina	49.02	7.00e-24	100.00
IUUC-Pyt-104733	Pyrenophora triticirepentis	53.19	4.00e-40	154.00
IUUC-Rno-106072	Rattus norvegicus	28.74	3.00e-12	62.40
IUUC-Sce-106275	Saccharomyces cerevisiae	45.98	2.00e-18	84.00
IUUC-Sha-107554	Sarcophilus harrisii	28.74	3.00e-12	62.40
IUUC-Sja-107682	Schizosaccharomyces japonicus	38.71	4.00e-24	101.00
IUUC-Spo-108275	Schizosaccharomyces pombe	43.68	4.00e-18	81.60
IUUC-Smo-109151	Selaginella moellendorffii	39.53	1.00e-12	62.40
IUUC-Sit-110270	Setaria italica	41.38	1.00e-14	68.90
IUUC-Sly-111862	Solanum lycopersicum	40.22	5.00e-14	67.00
IUUC-Stu-112663	Solanum tuberosum	37.78	1.00e-03	33.50
IUUC-Sbi-114148	Sorghum bicolor	41.38	1.00e-14	68.90
IUUC-Sre-115216	Sporisorium reilianum	49.49	1.00e-24	103.00
IUUC-Ssc-116051	Sus scrofa	27.59	5.00e-12	61.60
IUUC-Tru-118466	Takifugu rubripes	26.74	3.00e-09	50.80
IUUC-Tsy-119334	Tarsius syrichta	24.46	1.00e-08	50.80
IUUC-Tni-119792	Tetraodon nigroviridis	26.74	7.00e-10	53.10
IUUC-Tca-121861	Theobroma cacao	39.62	8.00e-14	67.00
IUUC-Tvi-122499	Trichoderma virens	60.33	5.00e-35	137.00
IUUC-Tae-123431	Triticum aestivum	41.38	2.00e-14	68.20
IUUC-Tme-126934	Tuber melanosporum	48.54	2.00e-25	106.00
IUUC-Ttr-129001	Tursiops truncatus	26.44	2.00e-08	50.10
IUUC-Uma-129324	Ustilago maydis	48.48	2.00e-24	102.00
IUUC-Vda-129846	Verticillium dahliae	61.67	2.00e-37	145.00
IUUC-Vpa-130202	Vicugna pacos	42.50	4.00e-06	42.70
IUUC-Vvi-131474	Vitis vinifera	42.86	1.00e-09	53.90
IUUC-Xtr-132782	Xenopus tropicalis	29.89	2.00e-12	63.20
IUUC-Xma-134140	Xiphophorus maculatus	25.53	2.00e-09	53.10
IUUC-Yli-134517	Yarrowia lipolytica	42.22	2.00e-16	77.00
IUUC-Zma-134764	Zea mays	41.38	1.00e-14	69.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence