iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
HINT	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG12	42.86	2.00e-17	84.70	IUUC-Hsa-046903

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Arabidopsis thaliana

Functional Description
(View)

Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. ATG12/ATG5 conjugate has an essential role in plant nutrient recycling.

Protein Sequence
(Fasta)

MATESPNSVQ KIVVHLRATG GAPILKQSKF KVSGSDKFAN VIDFLRRQLH SDSLFVYVNS 60
AFSPNPDESV IDLYNNFGFD GKLVVNYACS MAWG 94

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Nucleotide Sequence
(Fasta)

GAAATCTTTA ACTTCCTCCA AAATCGTTCT TCTCAAGTTT TTTCTACTTC CAAAGTCGCA 60
ACAATGGCGA CCGAATCTCC GAATTCTGTT CAGAAAAGTG AGCCATTGAT TCTTTGACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom

Pfam

PF04110--APG12

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0006501--P:C-terminal protein lipidation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG

ath:AT3G13970

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001177	Aegilops tauschii	75.29	1.00e-36	142.00
IUUC-Aml-002116	Ailuropoda melanoleuca	43.88	1.00e-18	84.70
IUUC-Atr-002615	Amborella trichopoda	80.85	5.00e-44	167.00
IUUC-Apl-003753	Anas platyrhynchos	55.00	1.00e-09	53.50
IUUC-Aca-005231	Anolis carolinensis	44.33	1.00e-14	71.20
IUUC-Aly-006172	Arabidopsis lyrata	88.30	6.00e-47	177.00
IUUC-Ago-007970	Ashbya gossypii	29.76	1.00e-05	42.00
IUUC-Acl-008072	Aspergillus clavatus	43.68	1.00e-15	73.90
IUUC-Afl-008725	Aspergillus flavus	43.68	9.00e-16	75.90
IUUC-Afu-008967	Aspergillus fumigatus	43.68	3.00e-15	73.90
IUUC-Ani-009248	Aspergillus nidulans	42.53	5.00e-15	73.20
IUUC-Ang-009684	Aspergillus niger	44.19	7.00e-15	72.80
IUUC-Aor-009947	Aspergillus oryzae	43.68	9.00e-16	75.90
IUUC-Ame-011656	Astyanax mexicanus	42.05	3.00e-15	73.20
IUUC-Bgr-012174	Blumeria graminis	42.70	1.00e-13	67.80
IUUC-Bta-012483	Bos taurus	42.86	9.00e-19	84.70
IUUC-Bci-013755	Botrytis cinerea	37.50	1.00e-10	57.80
IUUC-Bdi-014156	Brachypodium distachyon	76.47	2.00e-37	145.00
IUUC-Bol-015683	Brassica oleracea	89.13	2.00e-45	172.00
IUUC-Bra-016802	Brassica rapa	90.91	2.00e-44	169.00
IUUC-Cel-018242	Caenorhabditis elegans	32.97	3.00e-08	49.70
IUUC-Cja-019514	Callithrix jacchus	43.30	2.00e-18	84.70
IUUC-Cfa-020748	Canis familiaris	43.88	1.00e-18	85.10
IUUC-Cpo-021965	Cavia porcellus	43.88	1.00e-18	85.10
IUUC-Cre-023009	Chlamydomonas reinhardtii	50.59	2.00e-21	92.40
IUUC-Csa-023494	Chlorocebus sabaeus	42.86	1.00e-18	85.10
IUUC-Cho-024631	Choloepus hoffmanni	42.86	2.00e-18	84.30
IUUC-Cin-025609	Ciona intestinalis	49.43	6.00e-19	84.30
IUUC-Cgl-026722	Colletotrichum gloeosporioides	38.20	3.00e-12	63.20
IUUC-Dre-027479	Danio rerio	42.11	1.00e-16	77.80
IUUC-Dno-029693	Dasypus novemcinctus	37.36	3.00e-12	63.50
IUUC-Dse-031440	Dothistroma septosporum	40.23	2.00e-14	70.90
IUUC-Dme-031892	Drosophila melanogaster	36.78	7.00e-13	64.70
IUUC-Ete-032550	Echinops telfairi	41.67	7.00e-18	81.60
IUUC-Eca-033553	Equus caballus	42.86	9.00e-19	85.10
IUUC-Fca-036524	Felis catus	43.30	2.00e-18	84.30
IUUC-Fal-036942	Ficedula albicollis	41.67	6.00e-17	77.80
IUUC-Fox-037753	Fusarium oxysporum	39.80	3.00e-14	70.50
IUUC-Gmo-039498	Gadus morhua	42.05	5.00e-15	72.00
IUUC-Ggr-039852	Gaeumannomyces graminis	40.45	4.00e-12	63.90
IUUC-Gga-041263	Gallus gallus	42.86	5.00e-18	82.80
IUUC-Gac-042346	Gasterosteus aculeatus	42.86	5.00e-15	72.40
IUUC-Gma-042896	Glycine max	82.98	3.00e-45	171.00
IUUC-Ggo-045601	Gorilla gorilla	42.86	2.00e-18	84.70
IUUC-Hsa-046903	Homo sapiens	42.86	8.00e-19	85.10
IUUC-Hvu-047239	Hordeum vulgare	77.65	3.00e-37	145.00
IUUC-Itr-048445	Ictidomys tridecemlineatus	42.86	2.00e-18	84.30
IUUC-Kpa-049355	Komagataella pastoris	32.65	2.00e-11	60.80
IUUC-Lch-050619	Latimeria chalumnae	45.45	2.00e-17	80.50
IUUC-Lma-053299	Leptosphaeria maculans	37.84	8.00e-10	55.10
IUUC-Laf-054205	Loxodonta africana	41.84	3.00e-18	83.20
IUUC-Meu-056804	Macropus eugenii	43.88	9.00e-19	85.10
IUUC-Mor-057052	Magnaporthe oryzae	38.89	5.00e-12	63.50
IUUC-Mtr-057961	Medicago truncatula	87.10	3.00e-46	175.00
IUUC-Mla-059045	Melampsora laricipopulina	49.44	9.00e-24	100.00
IUUC-Mvi-060360	Microbotryum violaceum	52.87	8.00e-24	101.00
IUUC-Mmr-061654	Microcebus murinus	42.86	3.00e-18	82.80
IUUC-Mdo-062649	Monodelphis domestica	41.84	5.00e-18	82.80
IUUC-Mmu-064105	Mus musculus	42.86	1.00e-18	84.70
IUUC-Mac-065532	Musa acuminata	81.91	3.00e-44	168.00
IUUC-Mpu-066269	Mustela putorius furo	44.33	8.00e-19	85.10
IUUC-Mlu-067631	Myotis lucifugus	42.86	3.00e-18	84.00
IUUC-Nfi-068468	Neosartorya fischeri	43.68	2.00e-15	73.60
IUUC-Ncr-068750	Neurospora crassa	34.83	7.00e-11	58.90
IUUC-Nle-069483	Nomascus leucogenys	42.86	2.00e-18	84.70
IUUC-Opr-070936	Ochotona princeps	42.86	3.00e-18	84.00
IUUC-Obr-076322	Oryza brachyantha	72.94	2.00e-36	142.00
IUUC-Ogl-077226	Oryza glaberrima	73.75	2.00e-34	135.00
IUUC-Oin-079220	Oryza indica	71.88	7.00e-26	107.00
IUUC-Olo-080688	Oryza longistaminata	73.75	2.00e-34	135.00
IUUC-Ome-081265	Oryza meridionalis	73.75	2.00e-34	135.00
IUUC-Oru-084342	Oryza rufipogon	72.94	8.00e-36	142.00
IUUC-Osa-086212	Oryza sativa	73.75	2.00e-34	135.00
IUUC-Ola-087277	Oryzias latipes	43.18	6.00e-16	75.10
IUUC-Olu-087780	Ostreococcus lucimarinus	35.96	7.00e-13	64.30
IUUC-Oga-088175	Otolemur garnettii	42.86	7.00e-19	85.50
IUUC-Oar-089477	Ovis aries	42.86	2.00e-18	84.70
IUUC-Ptr-091129	Pan troglodytes	42.86	2.00e-18	84.70
IUUC-Psi-093351	Pelodiscus sinensis	41.94	5.00e-18	82.80
IUUC-Pno-094948	Phaeosphaeria nodorum	38.46	3.00e-09	53.50
IUUC-Ppa-095788	Physcomitrella patens	67.37	1.00e-36	143.00
IUUC-Pfo-096993	Poecilia formosa	40.91	3.00e-14	69.70
IUUC-Pab-098502	Pongo abelii	42.86	2.00e-18	84.70
IUUC-Pop-098819	Populus trichocarpa	69.15	1.00e-38	150.00
IUUC-Pca-100144	Procavia capensis	31.63	8.00e-08	49.30
IUUC-Ppe-101560	Prunus persica	87.80	1.00e-40	156.00
IUUC-Pva-102810	Pteropus vampyrus	38.46	2.00e-10	57.80
IUUC-Pgr-103531	Puccinia graminis	50.57	3.00e-23	99.00
IUUC-Ptt-103753	Puccinia triticina	50.57	6.00e-23	98.20
IUUC-Pyt-104733	Pyrenophora triticirepentis	41.86	1.00e-13	68.20
IUUC-Rno-106072	Rattus norvegicus	44.90	2.00e-19	87.00
IUUC-Sce-106275	Saccharomyces cerevisiae	37.21	1.00e-13	68.60
IUUC-Sha-107554	Sarcophilus harrisii	43.88	9.00e-19	85.10
IUUC-Sja-107682	Schizosaccharomyces japonicus	34.09	1.00e-13	68.20
IUUC-Spo-108275	Schizosaccharomyces pombe	37.50	3.00e-16	76.60
IUUC-Smo-109151	Selaginella moellendorffii	55.56	8.00e-25	103.00
IUUC-Sit-110270	Setaria italica	81.18	4.00e-39	151.00
IUUC-Sly-111862	Solanum lycopersicum	78.72	1.00e-41	159.00
IUUC-Stu-112663	Solanum tuberosum	92.86	1.00e-19	87.40
IUUC-Sbi-114148	Sorghum bicolor	81.18	4.00e-39	151.00
IUUC-Sre-115216	Sporisorium reilianum	44.83	2.00e-20	90.90
IUUC-Ssc-116051	Sus scrofa	42.86	9.00e-19	85.10
IUUC-Tru-118466	Takifugu rubripes	43.90	3.00e-15	72.00
IUUC-Tsy-119334	Tarsius syrichta	42.27	4.00e-14	70.10
IUUC-Tni-119792	Tetraodon nigroviridis	43.90	2.00e-15	73.20
IUUC-Tca-121861	Theobroma cacao	86.17	2.00e-46	176.00
IUUC-Tvi-122499	Trichoderma virens	44.32	7.00e-15	71.60
IUUC-Tae-123431	Triticum aestivum	75.29	1.00e-36	142.00
IUUC-Tme-126934	Tuber melanosporum	39.13	4.00e-14	70.10
IUUC-Ttr-129001	Tursiops truncatus	39.58	5.00e-14	69.70
IUUC-Uma-129324	Ustilago maydis	47.13	4.00e-21	92.80
IUUC-Vda-129846	Verticillium dahliae	42.05	3.00e-14	70.10
IUUC-Vpa-130202	Vicugna pacos	57.50	3.00e-10	57.40
IUUC-Vvi-131474	Vitis vinifera	80.00	6.00e-34	135.00
IUUC-Xtr-132782	Xenopus tropicalis	40.82	2.00e-17	80.10
IUUC-Xma-134140	Xiphophorus maculatus	42.05	7.00e-15	72.00
IUUC-Yli-134517	Yarrowia lipolytica	38.89	6.00e-13	66.60
IUUC-Zma-134764	Zea mays	76.60	3.00e-39	152.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence