iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000145860.11	ENST00000274542.6	ENSP00000274542.2
ENSG00000145860.11	ENST00000521606.6	ENSP00000430753.2
ENSG00000145860.11	ENST00000518802.5	ENSP00000430955.1
ENSG00000145860.11	ENST00000520638.1	ENSP00000429071.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.00e-09	38.9	567	604

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC++d+k   +++pC H+fha Cl+kw       + + +CPlC
   Q: 567  CAICYQDMKS-AVITPCSHFFHAGCLKKW------LYVQETCPLC 604
           ********99.888***************......********** PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MHRDRISPSN SPTWSLQVFS KKKKKKKKNN MAAKEKLEAV LNVALRVPSI MLLDVLYRWD 60
VSSFFQQIQR SSLSNNPLFQ YKYLALNMHY VGYILSVVLL TLPRQHLVQL YLYFLTALLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCATTCAT CCAGTCACTT ACTCCACAGG GGTTTGAGTG CCTGCACTTG GTGCTGGGCA 60
CGGCTGAGCC ATCCCAGACG CCAAGGAGTT TACAGTCTAG TCCAGTCAGT GACGAGGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:153830

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002354	Ailuropoda melanoleuca	95.26	0.00e+00	1213.00
IUUC-Apl-003823	Anas platyrhynchos	90.05	0.00e+00	1124.00
IUUC-Aca-004944	Anolis carolinensis	94.69	0.00e+00	1109.00
IUUC-Ame-011578	Astyanax mexicanus	88.79	0.00e+00	1007.00
IUUC-Bta-012560	Bos taurus	90.27	0.00e+00	1170.00
IUUC-Cel-018539	Caenorhabditis elegans	28.41	9.00e-63	235.00
IUUC-Cja-018929	Callithrix jacchus	97.04	0.00e+00	1244.00
IUUC-Cfa-021110	Canis familiaris	96.68	0.00e+00	1222.00
IUUC-Cpo-022452	Cavia porcellus	94.42	0.00e+00	1182.00
IUUC-Csa-024116	Chlorocebus sabaeus	99.40	0.00e+00	1267.00
IUUC-Csv-025845	Ciona savignyi	40.62	1.00e-32	132.00
IUUC-Dre-028299	Danio rerio	88.62	0.00e+00	1040.00
IUUC-Dno-029615	Dasypus novemcinctus	95.76	0.00e+00	1204.00
IUUC-Ete-032551	Echinops telfairi	70.72	0.00e+00	861.00
IUUC-Eca-033349	Equus caballus	97.27	0.00e+00	1120.00
IUUC-Eeu-035349	Erinaceus europaeus	98.05	0.00e+00	716.00
IUUC-Fca-035696	Felis catus	96.67	0.00e+00	1213.00
IUUC-Fal-037495	Ficedula albicollis	88.30	0.00e+00	1099.00
IUUC-Gmo-039374	Gadus morhua	85.08	0.00e+00	998.00
IUUC-Gga-040146	Gallus gallus	90.59	0.00e+00	1113.00
IUUC-Gac-041731	Gasterosteus aculeatus	83.44	0.00e+00	1015.00
IUUC-Ggo-045158	Gorilla gorilla	99.70	0.00e+00	1257.00
IUUC-Itr-048928	Ictidomys tridecemlineatus	95.38	0.00e+00	1094.00
IUUC-Lch-050499	Latimeria chalumnae	90.06	0.00e+00	1051.00
IUUC-Loc-052482	Lepisosteus oculatus	92.81	0.00e+00	1039.00
IUUC-Laf-053362	Loxodonta africana	96.35	0.00e+00	1200.00
IUUC-Mcc-055779	Macaca mulatta	98.84	0.00e+00	1282.00
IUUC-Meu-056130	Macropus eugenii	73.37	7.00e-150	524.00
IUUC-Mga-059742	Meleagris gallopavo	93.33	0.00e+00	1112.00
IUUC-Mmr-060812	Microcebus murinus	98.20	0.00e+00	1254.00
IUUC-Mdo-063045	Monodelphis domestica	92.69	0.00e+00	1127.00
IUUC-Mmu-064377	Mus musculus	93.82	0.00e+00	1191.00
IUUC-Mpu-066637	Mustela putorius furo	96.68	0.00e+00	1216.00
IUUC-Mlu-066985	Myotis lucifugus	94.92	0.00e+00	1173.00
IUUC-Nle-069833	Nomascus leucogenys	99.54	0.00e+00	1255.00
IUUC-Opr-070210	Ochotona princeps	85.07	2.00e-138	486.00
IUUC-Ont-072116	Oreochromis niloticus	83.10	0.00e+00	1039.00
IUUC-Oan-073730	Ornithorhynchus anatinus	93.36	0.00e+00	1139.00
IUUC-Ocu-074958	Oryctolagus cuniculus	95.02	0.00e+00	1201.00
IUUC-Ola-087368	Oryzias latipes	88.97	0.00e+00	1019.00
IUUC-Oga-088301	Otolemur garnettii	98.01	0.00e+00	1229.00
IUUC-Oar-089745	Ovis aries	95.02	0.00e+00	1191.00
IUUC-Ptr-091397	Pan troglodytes	99.86	0.00e+00	1317.00
IUUC-Pan-092817	Papio anubis	99.55	0.00e+00	1268.00
IUUC-Psi-093820	Pelodiscus sinensis	87.52	0.00e+00	1078.00
IUUC-Pma-094457	Petromyzon marinus	66.87	3.00e-171	594.00
IUUC-Pfo-097173	Poecilia formosa	83.25	0.00e+00	1029.00
IUUC-Pab-097630	Pongo abelii	99.55	0.00e+00	1265.00
IUUC-Pca-100472	Procavia capensis	92.62	0.00e+00	1164.00
IUUC-Pva-102485	Pteropus vampyrus	94.44	0.00e+00	1118.00
IUUC-Rno-106029	Rattus norvegicus	94.43	0.00e+00	1159.00
IUUC-Sha-106580	Sarcophilus harrisii	92.97	0.00e+00	1149.00
IUUC-Ssc-116438	Sus scrofa	94.44	0.00e+00	1088.00
IUUC-Tgu-116638	Taeniopygia guttata	89.59	0.00e+00	1095.00
IUUC-Tru-117779	Takifugu rubripes	85.78	0.00e+00	1031.00
IUUC-Tsy-119541	Tarsius syrichta	94.63	0.00e+00	1164.00
IUUC-Tni-119862	Tetraodon nigroviridis	85.65	0.00e+00	1031.00
IUUC-Tbe-127328	Tupaia belangeri	89.91	0.00e+00	1060.00
IUUC-Ttr-129066	Tursiops truncatus	95.33	2.00e-179	622.00
IUUC-Xtr-132826	Xenopus tropicalis	86.94	0.00e+00	1084.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence