iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046509

UUCD1 version

UUC-HoS-00259

Ensembl Protein ID

ENSP00000320869.5

UniProt Accession

Q8WV44; B3KNJ6; D3DWR9; Q5BKT0; Q7L484; Q96Q10; Q9BSL8; TRI41_HUMAN

Genbank Protein ID

BAD07472.1; BAD07473.1; AAG23782.1; CAG33630.1; BAG51358.1; EAW53712.1; EAW53708.1; EAW53709.1; AAH04956.1; AAH09762.2; AAH18765.2; AAH71887.1; AAH90953.1; BAB70617.1

Protein Name

E3 ubiquitin-protein ligase TRIM41; RING finger-interacting protein with C kinase; RING-type E3 ubiquitin transferase TRIM41; Tripartite motif-containing protein 41

Genbank Nucleotide ID

AB100366; AB100367; AF258579; CR457349; AK027601; CH471165; CH471165; CH471165; BC004956; BC009762; BC018765; BC071887; BC090953; AB063180

Gene Name

TRIM41; RINCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000146063.18	ENST00000351937.9	ENSP00000336749.6
ENSG00000146063.18	ENST00000315073.9	ENSP00000320869.5
ENSG00000146063.18	ENST00000503114.1	ENSP00000424979.1
ENSG00000146063.18	ENST00000514219.1	ENSP00000426790.1
ENSG00000146063.18	ENST00000617715.1	ENSP00000483672.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090; 17893151; 23936368

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	3.60e-07	32.2	20	48

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw 29
           CaiCl+ f d p++ +CgH f++ C+ q w
   Q: 20   CAICLDYFTD-PVSIGCGHNFCRVCVtQLW 48
           **********.**************98888 PP

Organism

Homo sapiens

Functional Description
(View)

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.

Protein Sequence
(Fasta)

MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG EDEEDRDELD 60
REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE EEEEGVFWTS GMSRSSWDNM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAAGACACA CACGGCTGAG ACGGCCGGGA TAGCTCTAGG CAAGCGCCCT TGTAGGACAG 60
GCCCGGGGAC CCCTGCCGCG GCCGGCTGAG CGGTGTCCAG GTTCTGGAGC CGGACTTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0042802--F:identical protein binding
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

hsa:90933

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001322	Ailuropoda melanoleuca	97.13	0.00e+00	764.00
IUUC-Apl-003945	Anas platyrhynchos	48.81	2.00e-119	422.00
IUUC-Aca-005336	Anolis carolinensis	56.29	2.00e-128	452.00
IUUC-Bta-013326	Bos taurus	92.78	0.00e+00	789.00
IUUC-Cja-019205	Callithrix jacchus	91.90	0.00e+00	865.00
IUUC-Cfa-021129	Canis familiaris	98.68	0.00e+00	746.00
IUUC-Cpo-021839	Cavia porcellus	95.81	0.00e+00	791.00
IUUC-Csa-023274	Chlorocebus sabaeus	99.68	3.00e-168	585.00
IUUC-Dno-029811	Dasypus novemcinctus	98.45	0.00e+00	740.00
IUUC-Dor-030241	Dipodomys ordii	92.54	0.00e+00	827.00
IUUC-Ete-032275	Echinops telfairi	95.58	0.00e+00	763.00
IUUC-Eca-033589	Equus caballus	95.80	0.00e+00	766.00
IUUC-Eeu-034925	Erinaceus europaeus	96.38	6.00e-157	546.00
IUUC-Fca-035840	Felis catus	98.68	0.00e+00	745.00
IUUC-Gga-041240	Gallus gallus	54.14	2.00e-135	476.00
IUUC-Ggo-044681	Gorilla gorilla	100.00	2.00e-150	525.00
IUUC-Itr-049027	Ictidomys tridecemlineatus	96.03	0.00e+00	891.00
IUUC-Laf-053825	Loxodonta africana	89.86	0.00e+00	867.00
IUUC-Mcc-055711	Macaca mulatta	97.58	0.00e+00	734.00
IUUC-Meu-056203	Macropus eugenii	82.80	1.00e-91	330.00
IUUC-Mga-059640	Meleagris gallopavo	51.11	8.00e-73	267.00
IUUC-Mmr-060876	Microcebus murinus	99.12	0.00e+00	757.00
IUUC-Mdo-062529	Monodelphis domestica	82.28	0.00e+00	805.00
IUUC-Mmu-063812	Mus musculus	90.81	0.00e+00	884.00
IUUC-Mpu-066336	Mustela putorius furo	98.90	0.00e+00	746.00
IUUC-Mlu-067141	Myotis lucifugus	92.75	0.00e+00	700.00
IUUC-Nle-069155	Nomascus leucogenys	99.05	4.00e-168	584.00
IUUC-Opr-070782	Ochotona princeps	76.60	7.00e-122	430.00
IUUC-Ocu-073999	Oryctolagus cuniculus	96.69	0.00e+00	779.00
IUUC-Oga-088046	Otolemur garnettii	98.45	0.00e+00	752.00
IUUC-Oar-090410	Ovis aries	93.81	0.00e+00	734.00
IUUC-Pan-092338	Papio anubis	99.68	4.00e-167	581.00
IUUC-Pab-098117	Pongo abelii	99.68	3.00e-168	585.00
IUUC-Pop-099794	Populus trichocarpa	41.86	5.00e-07	47.00
IUUC-Pca-100768	Procavia capensis	95.51	3.00e-83	303.00
IUUC-Pva-102341	Pteropus vampyrus	95.25	0.00e+00	628.00
IUUC-Rno-106006	Rattus norvegicus	93.97	0.00e+00	894.00
IUUC-Sha-106482	Sarcophilus harrisii	88.03	0.00e+00	707.00
IUUC-Sar-113654	Sorex araneus	92.09	0.00e+00	758.00
IUUC-Ssc-115807	Sus scrofa	95.88	2.00e-117	416.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence