iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000146083.11	ENST00000274811.8	ENSP00000274811.4
ENSG00000146083.11	ENST00000506378.1	ENSP00000425253.1
ENSG00000146083.11	ENST00000513029.5	ENSP00000427604.1
ENSG00000146083.11	ENST00000504160.1	ENSP00000424699.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.90e-09	38.0	380	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C++df+    ++vlpC+H fh++C+ kw       + + +CP+Cr
   Q: 380  CVVCFSDFEARqlLRVLPCNHEFHTKCVDKW------LKANRTCPICR 421
           ********5545699****************......**********8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MRPWALAVTR WPPSAPVGQR RFSAGPGSTP GQLWGSPGLE GPLASPPARD ERLPSQQPPS 60
RPPHLPVEER RASAPAGGSP RMLHPATQQS PFMVDLHEQV HQGPVPLSYT VTTVTTQGFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACGTTAGC TCGTTTGCAT GGGTGGTCCG CCATTGGTCT GTTGGGCAAT CTGGGCCGTA 60
CCAGCTTTTT AAAGACGCCG TGTAGTATAA ACAAGGAGAA GTGGGGCGGC CGGGCCATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

hsa:22838

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001093	Aegilops tauschii	30.83	1.00e-15	77.80
IUUC-Aml-002180	Ailuropoda melanoleuca	90.97	0.00e+00	669.00
IUUC-Aca-004353	Anolis carolinensis	74.05	4.00e-155	541.00
IUUC-Aly-005825	Arabidopsis lyrata	40.00	6.00e-14	71.60
IUUC-Ath-007389	Arabidopsis thaliana	40.00	6.00e-14	71.60
IUUC-Ame-011569	Astyanax mexicanus	65.78	7.00e-131	460.00
IUUC-Bta-012954	Bos taurus	93.29	0.00e+00	702.00
IUUC-Bol-015622	Brassica oleracea	40.00	2.00e-13	70.10
IUUC-Bra-017837	Brassica rapa	40.00	5.00e-14	71.60
IUUC-Cja-019606	Callithrix jacchus	94.87	4.00e-171	593.00
IUUC-Cfa-020959	Canis familiaris	93.89	0.00e+00	710.00
IUUC-Cpo-022130	Cavia porcellus	91.90	0.00e+00	731.00
IUUC-Cre-022984	Chlamydomonas reinhardtii	33.68	3.00e-12	68.20
IUUC-Csa-024265	Chlorocebus sabaeus	98.15	0.00e+00	733.00
IUUC-Dno-030071	Dasypus novemcinctus	93.94	0.00e+00	693.00
IUUC-Dor-030199	Dipodomys ordii	80.32	5.00e-175	607.00
IUUC-Eca-034105	Equus caballus	95.37	0.00e+00	691.00
IUUC-Fca-036360	Felis catus	95.60	0.00e+00	710.00
IUUC-Fal-037494	Ficedula albicollis	77.65	2.00e-168	585.00
IUUC-Gmo-038772	Gadus morhua	63.15	1.00e-130	459.00
IUUC-Gga-040521	Gallus gallus	77.43	1.00e-167	582.00
IUUC-Gac-041636	Gasterosteus aculeatus	65.84	3.00e-129	455.00
IUUC-Gma-042757	Glycine max	47.22	1.00e-15	77.00
IUUC-Ggo-044732	Gorilla gorilla	95.60	0.00e+00	709.00
IUUC-Itr-048694	Ictidomys tridecemlineatus	95.61	0.00e+00	687.00
IUUC-Lch-050227	Latimeria chalumnae	72.91	4.00e-153	534.00
IUUC-Loc-052302	Lepisosteus oculatus	68.82	1.00e-142	499.00
IUUC-Laf-053419	Loxodonta africana	85.42	0.00e+00	669.00
IUUC-Mcc-054969	Macaca mulatta	98.58	9.00e-179	619.00
IUUC-Meu-056404	Macropus eugenii	82.57	0.00e+00	647.00
IUUC-Mla-058928	Melampsora laricipopulina	39.39	4.00e-10	58.20
IUUC-Mdo-062309	Monodelphis domestica	87.10	3.00e-154	538.00
IUUC-Mmu-063712	Mus musculus	89.84	0.00e+00	671.00
IUUC-Mac-065494	Musa acuminata	49.28	4.00e-15	75.90
IUUC-Mpu-066508	Mustela putorius furo	96.03	0.00e+00	696.00
IUUC-Mlu-068210	Myotis lucifugus	92.38	0.00e+00	642.00
IUUC-Nle-069124	Nomascus leucogenys	96.30	0.00e+00	716.00
IUUC-Opr-071167	Ochotona princeps	91.32	6.00e-160	556.00
IUUC-Ont-072090	Oreochromis niloticus	64.56	1.00e-121	429.00
IUUC-Ocu-074801	Oryctolagus cuniculus	74.72	7.00e-160	556.00
IUUC-Oba-075724	Oryza barthii	34.96	1.00e-15	78.20
IUUC-Obr-076624	Oryza brachyantha	31.71	3.00e-15	76.60
IUUC-Ogl-077689	Oryza glaberrima	34.96	1.00e-15	78.20
IUUC-Ogu-078097	Oryza glumaepatula	37.29	4.00e-17	82.40
IUUC-Oin-079530	Oryza indica	34.96	9.00e-16	78.20
IUUC-Olo-080582	Oryza longistaminata	35.71	9.00e-16	78.20
IUUC-Ome-081876	Oryza meridionalis	34.65	6.00e-16	79.00
IUUC-Oni-082354	Oryza nivara	34.96	1.00e-15	78.20
IUUC-Opu-084138	Oryza punctata	35.64	2.00e-15	77.00
IUUC-Oru-085113	Oryza rufipogon	34.96	1.00e-15	78.20
IUUC-Osa-085539	Oryza sativa	34.96	1.00e-15	78.20
IUUC-Ola-086948	Oryzias latipes	66.59	5.00e-127	447.00
IUUC-Oga-087987	Otolemur garnettii	94.31	0.00e+00	724.00
IUUC-Oar-089245	Ovis aries	89.75	0.00e+00	681.00
IUUC-Ptr-091155	Pan troglodytes	99.54	0.00e+00	746.00
IUUC-Pan-092597	Papio anubis	98.84	0.00e+00	746.00
IUUC-Pfo-096747	Poecilia formosa	67.27	2.00e-126	445.00
IUUC-Pab-098133	Pongo abelii	87.39	8.00e-159	552.00
IUUC-Pca-100961	Procavia capensis	89.81	0.00e+00	682.00
IUUC-Ppe-102055	Prunus persica	38.89	5.00e-16	78.60
IUUC-Pva-102987	Pteropus vampyrus	89.35	0.00e+00	642.00
IUUC-Rno-105434	Rattus norvegicus	93.18	1.00e-164	572.00
IUUC-Sha-107023	Sarcophilus harrisii	75.74	9.00e-172	596.00
IUUC-Sit-109970	Setaria italica	44.00	6.00e-15	75.10
IUUC-Sar-113463	Sorex araneus	82.70	2.00e-131	461.00
IUUC-Sbi-114529	Sorghum bicolor	45.33	1.00e-15	77.40
IUUC-Ssc-115578	Sus scrofa	95.83	0.00e+00	715.00
IUUC-Tgu-117430	Taeniopygia guttata	77.88	5.00e-164	570.00
IUUC-Tru-117715	Takifugu rubripes	67.19	1.00e-131	462.00
IUUC-Tni-119691	Tetraodon nigroviridis	66.74	2.00e-131	462.00
IUUC-Tae-123235	Triticum aestivum	31.90	1.00e-15	77.80
IUUC-Tbe-127519	Tupaia belangeri	87.08	4.00e-142	497.00
IUUC-Ttr-128179	Tursiops truncatus	95.60	0.00e+00	722.00
IUUC-Xtr-132852	Xenopus tropicalis	71.43	1.00e-145	509.00
IUUC-Xma-133465	Xiphophorus maculatus	64.56	4.00e-122	431.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence