| Tag | Content | ||||||
|---|---|---|---|---|---|---|---|
| UUCD2 ID | IUUC-Hsa-136371 | ||||||
| Ensembl Protein ID | ENSP00000482724.1 | ||||||
| UniProt Accession | O15372; EIF3H_HUMAN | ||||||
| Genbank Protein ID | U54559; AF092576; AF092569; AF092570; AF092571; AF092572; AF092573; AF092574; AF092575; BC000386 | ||||||
| Protein Name | Eukaryotic translation initiation factor 3 subunit H;Eukaryotic translation initiation factor 3 subunit 3;eIF-3-gamma;eIF3 p40 subunit | ||||||
| Genbank Nucleotide ID | AAD03465.1; AAC84044.1; AAC84044.1; AAC84044.1; AAC84044.1; AAC84044.1; AAC84044.1; AAC84044.1; AAC84044.1; AAH00386.1 | ||||||
| Gene Name | EIF3H;EIF3S3 | ||||||
| Ensembl Information | |||||||
| Status | Reviewed | ||||||
| Details |
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| Organism | Homo sapiens | ||||||
| Functional Description (View) |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). | ||||||
| Protein Sequence (Fasta) |
MASRKEGTGS TATSSSSTAG AAGKGKGKGG SGDSAVKQVQ IDGLVVLKII KHYQEEGQGT 60
EVVQGVLLGL VVEDRLEITN CFPFPQHTED DADFDEVQYQ MEMMRSLRHV NIDHLHVGWY 120 It may take some time, please wait.
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| Sequence Source | UniProt | ||||||
| Keyword | KW-0002--3D-structure |
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| Interpro | |||||||
| Pfam | PF01398--JAB |
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| SMART | SM00232--JAB_MPN |
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| Gene Ontology | GO:0005829--C:cytosol |
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| KEGG | hsa:8667 | ||||||
| Created Date | 25-Jun-2017 |
