iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046254

Ensembl Protein ID

ENSP00000372035.4

UniProt Accession

Q9NRM7; B1AM47; Q9P2X1; LATS2_HUMAN

Genbank Protein ID

AAF80561.1; BAG36905.1; CAH71526.1; CAH71526.1; CAI15861.1; CAI15861.1; EAX08286.1; BAA92381.1

Protein Name

Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase

Genbank Nucleotide ID

AF207547; AK314235; AL161613; AL356285; AL356285; AL161613; CH471075; AB028019

Gene Name

LATS2; KPM

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000150457.8	ENST00000382592.4	ENSP00000372035.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	21233212; 25026211; 26598551

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	5.10e-05	24.9	100	137

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLl 39
           + ++l++lv+ G+d+e a +aL ++ + ++eaA+ey+ 
   Q: 100  NRQMLQELVNAGCDQEMAGRALKQTgSRSIEAALEYIS 137
           669*********************************86 PP

Organism

Homo sapiens

Functional Description
(View)

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

Protein Sequence
(Fasta)

MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSVQGLPAG PNSDTSLDAK VLGSKDATRQ 60
QQQMRATPKF GPYQKALREI RYSLLPFANE SGTSAAAEVN RQMLQELVNA GCDQEMAGRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGGTCTGC GCTTTGGAAC CGCGGCGTGA GCGCCCCGGG AAGATGGAGC AGTCGCCGTC 60
CACGCCACCG CCGCCGCCCG GGGCTCCCCC GTCCCTGCGG GGCCAGCAGC AGCTCCAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0043--Tumor suppressor

Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS51285--AGC_KINASE_CTER
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase

SMART

SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051301--P:cell division
GO:0034613--P:cellular protein localization
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0035556--P:intracellular signal transduction
GO:0030216--P:keratinocyte differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0006468--P:protein phosphorylation
GO:0046620--P:regulation of organ growth

KEGG

hsa:26524

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001960	Ailuropoda melanoleuca	85.56	0.00e+00	1894.00
IUUC-Apl-003521	Anas platyrhynchos	73.63	0.00e+00	1282.00
IUUC-Aca-004995	Anolis carolinensis	73.78	0.00e+00	1566.00
IUUC-Ame-011481	Astyanax mexicanus	61.59	0.00e+00	1235.00
IUUC-Bta-012618	Bos taurus	85.36	0.00e+00	997.00
IUUC-Cja-019430	Callithrix jacchus	94.32	0.00e+00	1995.00
IUUC-Cfa-020687	Canis familiaris	85.41	0.00e+00	1841.00
IUUC-Cpo-021985	Cavia porcellus	86.80	0.00e+00	1084.00
IUUC-Csa-023534	Chlorocebus sabaeus	98.96	0.00e+00	1024.00
IUUC-Cho-024363	Choloepus hoffmanni	79.02	0.00e+00	731.00
IUUC-Dre-027538	Danio rerio	60.95	0.00e+00	1247.00
IUUC-Dno-029126	Dasypus novemcinctus	82.71	0.00e+00	1861.00
IUUC-Dor-030172	Dipodomys ordii	86.68	0.00e+00	1632.00
IUUC-Eca-033868	Equus caballus	84.66	0.00e+00	1831.00
IUUC-Eeu-034881	Erinaceus europaeus	69.62	0.00e+00	1361.00
IUUC-Fca-036203	Felis catus	81.41	0.00e+00	1703.00
IUUC-Fal-036668	Ficedula albicollis	74.96	0.00e+00	1669.00
IUUC-Gmo-039195	Gadus morhua	85.05	0.00e+00	780.00
IUUC-Gac-041789	Gasterosteus aculeatus	84.66	0.00e+00	875.00
IUUC-Ggo-044904	Gorilla gorilla	94.12	0.00e+00	1951.00
IUUC-Itr-047948	Ictidomys tridecemlineatus	88.31	0.00e+00	1670.00
IUUC-Lch-050079	Latimeria chalumnae	66.26	0.00e+00	1452.00
IUUC-Loc-052265	Lepisosteus oculatus	83.50	0.00e+00	869.00
IUUC-Laf-053806	Loxodonta africana	84.05	0.00e+00	1849.00
IUUC-Mcc-055253	Macaca mulatta	96.24	0.00e+00	1958.00
IUUC-Meu-056509	Macropus eugenii	83.52	0.00e+00	812.00
IUUC-Mga-059600	Meleagris gallopavo	74.43	0.00e+00	1669.00
IUUC-Mmr-061586	Microcebus murinus	89.44	0.00e+00	1803.00
IUUC-Mdo-062126	Monodelphis domestica	75.20	0.00e+00	1634.00
IUUC-Mmu-063164	Mus musculus	81.70	0.00e+00	1655.00
IUUC-Mpu-065992	Mustela putorius furo	84.93	0.00e+00	1876.00
IUUC-Mlu-067728	Myotis lucifugus	77.97	0.00e+00	1605.00
IUUC-Nle-069546	Nomascus leucogenys	98.07	0.00e+00	1962.00
IUUC-Opr-070872	Ochotona princeps	84.63	0.00e+00	1761.00
IUUC-Ont-072296	Oreochromis niloticus	86.53	0.00e+00	911.00
IUUC-Ocu-074068	Oryctolagus cuniculus	84.77	0.00e+00	1767.00
IUUC-Ola-086756	Oryzias latipes	86.12	0.00e+00	908.00
IUUC-Oga-089066	Otolemur garnettii	89.56	0.00e+00	1931.00
IUUC-Oar-090416	Ovis aries	85.02	0.00e+00	993.00
IUUC-Ptr-091247	Pan troglodytes	99.45	0.00e+00	2010.00
IUUC-Pan-092438	Papio anubis	96.24	0.00e+00	1957.00
IUUC-Psi-093920	Pelodiscus sinensis	73.77	0.00e+00	1643.00
IUUC-Pfo-096334	Poecilia formosa	85.05	0.00e+00	890.00
IUUC-Pab-098452	Pongo abelii	97.09	0.00e+00	1998.00
IUUC-Pca-101081	Procavia capensis	79.40	0.00e+00	1741.00
IUUC-Pva-103036	Pteropus vampyrus	82.33	0.00e+00	766.00
IUUC-Rno-105102	Rattus norvegicus	82.34	0.00e+00	1659.00
IUUC-Sha-106917	Sarcophilus harrisii	74.85	0.00e+00	1640.00
IUUC-Sar-113711	Sorex araneus	79.28	0.00e+00	1520.00
IUUC-Tgu-116553	Taeniopygia guttata	77.68	0.00e+00	1696.00
IUUC-Tru-118069	Takifugu rubripes	85.31	0.00e+00	899.00
IUUC-Tni-120617	Tetraodon nigroviridis	81.92	0.00e+00	887.00
IUUC-Ttr-129256	Tursiops truncatus	86.86	0.00e+00	1014.00
IUUC-Xtr-132593	Xenopus tropicalis	71.09	0.00e+00	1529.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence