iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000150627.15	ENST00000508596.5	ENSP00000422763.1
ENSG00000150627.15	ENST00000280190.8	ENSP00000280190.4
ENSG00000150627.15	ENST00000507824.6	ENSP00000422200.2
ENSG00000150627.15	ENST00000513261.1	ENSP00000427502.1
ENSG00000150627.15	ENST00000505894.2	ENSP00000426847.2
ENSG00000150627.15	ENST00000443118.3	ENSP00000426985.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	Mentha
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.40e-53	176.2	607	646
UBD/Beta-Prp	1.30e-67	229.7	518	683

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd..tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v++l + ++   ll+sGs+D tikvWD+r+g+++ 
   Q: 607  GHTAPVRGLMWnTEipYLLISGSWDYTIKVWDTREGTCVD 646
           8**********85573668******************986 PP

UBD/Beta-Prp

   S: 49   sgheaevtavkfspdgk.ilvtgseDrtikvw..dlstgkcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdletgqcleetlsgh 136
           ++h a+v  +++s++ k +++tg eD +++v+    s+ +++ +++gh+++v  +++sp     l sGs+d t+r+wd  ++ c++ +l+gh
   Q: 518  YKHPAAVFGCDWSQNNKdMIATGCEDTNVRVYyvATSSDQPLKVFSGHTAKVFHVKWSPlREGILCSGSDDGTVRIWDYTQDACIN-ILNGH 608
           67888888888887766688888888888888777778888888888888888888888555888888888888888888888888.88888 PP
   S: 137  dgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq 210
           ++ v+++ ++ +   ll+sGs D t+++Wd + g++++t    h  +vy l+ ++++ + ++s+s+d+tv+lw+l 
   Q: 609  TAPVRGLMWNTEIpYLLISGSWDYTIKVWDTREGTCVDTVYD-HGADVYGLTCHPSRpFTMASCSRDSTVRLWSLT 683
           888888888888888888888888888888888888888876.888888888888877888888888888888874 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAWMTYISNW FEQDDWYEGL QRANMSQVRQ VGLLAAGCQP WNKDVCAASG DRFAYCATLA 60
IYIYQLDHRY NEFKLHAIMS EHKKTITAIS WCPHNPDLFA SGSTDNLVII WNVAEQKVIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCTGGGG CAGACCCTGG AGATCGGGCT CGCGGCGCCT TCCATCGTGG CTCCGCGCTG 60
GGGCTTGCGG AGCACGCTTC CCGCCCCTCG GAGCCCGCGG GCCCGGCCGC CCCGCCCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm

KEGG

hsa:116966

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001190	Ailuropoda melanoleuca	90.85	0.00e+00	2487.00
IUUC-Apl-003326	Anas platyrhynchos	84.72	0.00e+00	2301.00
IUUC-Aca-004349	Anolis carolinensis	84.30	0.00e+00	2288.00
IUUC-Ame-011366	Astyanax mexicanus	60.36	0.00e+00	1482.00
IUUC-Bta-013275	Bos taurus	90.69	0.00e+00	2476.00
IUUC-Cja-018970	Callithrix jacchus	95.84	0.00e+00	2645.00
IUUC-Cfa-021237	Canis familiaris	91.09	0.00e+00	2539.00
IUUC-Cpo-021342	Cavia porcellus	86.05	0.00e+00	1660.00
IUUC-Cre-022569	Chlamydomonas reinhardtii	28.67	7.00e-81	295.00
IUUC-Csa-023687	Chlorocebus sabaeus	97.05	0.00e+00	2675.00
IUUC-Cho-024772	Choloepus hoffmanni	79.43	0.00e+00	799.00
IUUC-Csv-026021	Ciona savignyi	40.88	0.00e+00	1026.00
IUUC-Dre-028031	Danio rerio	80.25	0.00e+00	2187.00
IUUC-Dno-029369	Dasypus novemcinctus	86.60	0.00e+00	2279.00
IUUC-Dor-030645	Dipodomys ordii	88.88	0.00e+00	2460.00
IUUC-Ete-032530	Echinops telfairi	85.48	0.00e+00	2345.00
IUUC-Eca-034405	Equus caballus	90.92	0.00e+00	2490.00
IUUC-Eeu-035006	Erinaceus europaeus	86.59	0.00e+00	1085.00
IUUC-Fca-035965	Felis catus	90.01	0.00e+00	2452.00
IUUC-Fal-037136	Ficedula albicollis	83.47	0.00e+00	2289.00
IUUC-Gmo-039293	Gadus morhua	75.16	0.00e+00	1962.00
IUUC-Gga-040931	Gallus gallus	81.86	0.00e+00	2251.00
IUUC-Gac-042493	Gasterosteus aculeatus	74.85	0.00e+00	2013.00
IUUC-Ggo-045540	Gorilla gorilla	98.54	0.00e+00	2650.00
IUUC-Lch-050135	Latimeria chalumnae	82.17	0.00e+00	1724.00
IUUC-Loc-051730	Lepisosteus oculatus	84.17	0.00e+00	2295.00
IUUC-Laf-053743	Loxodonta africana	91.15	0.00e+00	2463.00
IUUC-Mcc-055590	Macaca mulatta	96.90	0.00e+00	2672.00
IUUC-Meu-056328	Macropus eugenii	67.20	0.00e+00	1672.00
IUUC-Mga-059877	Meleagris gallopavo	80.94	0.00e+00	2197.00
IUUC-Mmr-060756	Microcebus murinus	93.57	0.00e+00	2590.00
IUUC-Mdo-062749	Monodelphis domestica	84.67	0.00e+00	2330.00
IUUC-Mmu-063668	Mus musculus	88.35	0.00e+00	2471.00
IUUC-Mpu-066856	Mustela putorius furo	90.47	0.00e+00	2495.00
IUUC-Mlu-067186	Myotis lucifugus	84.82	0.00e+00	2325.00
IUUC-Nle-070018	Nomascus leucogenys	98.23	0.00e+00	2665.00
IUUC-Ont-071482	Oreochromis niloticus	69.99	0.00e+00	1859.00
IUUC-Oan-073065	Ornithorhynchus anatinus	83.46	0.00e+00	1795.00
IUUC-Ocu-073786	Oryctolagus cuniculus	91.77	0.00e+00	2484.00
IUUC-Oga-088545	Otolemur garnettii	87.44	0.00e+00	2415.00
IUUC-Oar-090205	Ovis aries	88.89	0.00e+00	2492.00
IUUC-Ptr-091092	Pan troglodytes	99.47	0.00e+00	2739.00
IUUC-Pan-092430	Papio anubis	96.97	0.00e+00	2672.00
IUUC-Psi-093774	Pelodiscus sinensis	85.40	0.00e+00	2320.00
IUUC-Pfo-097414	Poecilia formosa	74.39	0.00e+00	1957.00
IUUC-Pab-097853	Pongo abelii	98.71	0.00e+00	2722.00
IUUC-Pca-100440	Procavia capensis	76.98	0.00e+00	805.00
IUUC-Pva-102838	Pteropus vampyrus	90.62	0.00e+00	2513.00
IUUC-Rno-104951	Rattus norvegicus	86.01	0.00e+00	2393.00
IUUC-Sha-107508	Sarcophilus harrisii	84.64	0.00e+00	2336.00
IUUC-Sar-113549	Sorex araneus	87.63	0.00e+00	1602.00
IUUC-Ssc-115753	Sus scrofa	90.72	0.00e+00	1952.00
IUUC-Tgu-117315	Taeniopygia guttata	83.45	0.00e+00	2274.00
IUUC-Tru-118153	Takifugu rubripes	74.58	0.00e+00	1996.00
IUUC-Tsy-119384	Tarsius syrichta	86.26	0.00e+00	2371.00
IUUC-Tni-120820	Tetraodon nigroviridis	78.24	5.00e-105	373.00
IUUC-Tbe-127579	Tupaia belangeri	80.60	0.00e+00	1089.00
IUUC-Ttr-128488	Tursiops truncatus	84.19	0.00e+00	2323.00
IUUC-Vpa-130274	Vicugna pacos	84.89	0.00e+00	1058.00
IUUC-Xtr-132199	Xenopus tropicalis	84.88	0.00e+00	2325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence