iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000153487.12	ENST00000338450.7	ENSP00000345202.7
ENSG00000153487.12	ENST00000333219.8	ENSP00000328436.7
ENSG00000153487.12	ENST00000375774.3	ENSP00000364929.3
ENSG00000153487.12	ENST00000464141.1	ENSP00000480985.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRecords	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	21731648

Classification

Family	E-value	Score	Start	End
E3 activity/RING/PHD	2.50e-08	35.6	354	401

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr 
   Q: 354  TYC-LCNQVSYGE--MIGCDNdeCPiEWFHFSCVGLN---HKPKGK-WYCPKCRG 401
           69*.*******99..******9**99***********...999997.******85 PP

Organism

Homo sapiens

Functional Description
(View)

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Protein Sequence
(Fasta)

MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG RVDLNVFGSL 60
GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG GSRGAGRVSR WPPPHWLEAW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCCGAGAA CGGTGTCCAT GACACAGGGC GGGAAGAGAT AAGGCCTAGG GAAGGCGCCC 60
CTCGGGCCTA TCCACCTCTT CTGGGGCTCG GCACTAGGAA GCAGCTTCCC TCTCAGGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028643--ING1
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0010941--P:regulation of cell death

KEGG

hsa:3621

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001945	Ailuropoda melanoleuca	87.71	2.00e-98	352.00
IUUC-Apl-003910	Anas platyrhynchos	87.66	3.00e-96	344.00
IUUC-Aca-004874	Anolis carolinensis	86.44	6.00e-95	340.00
IUUC-Ame-011262	Astyanax mexicanus	67.21	1.00e-75	276.00
IUUC-Bta-013507	Bos taurus	87.18	7.00e-88	316.00
IUUC-Cja-018925	Callithrix jacchus	98.31	3.00e-109	387.00
IUUC-Cfa-020947	Canis familiaris	87.29	3.00e-97	347.00
IUUC-Cpo-022286	Cavia porcellus	71.39	8.00e-109	386.00
IUUC-Csa-023825	Chlorocebus sabaeus	97.88	8.00e-109	386.00
IUUC-Cho-024577	Choloepus hoffmanni	88.84	7.00e-96	343.00
IUUC-Cne-027005	Cryptococcus neoformans	45.95	7.00e-16	78.20
IUUC-Dno-029834	Dasypus novemcinctus	88.14	1.00e-98	352.00
IUUC-Dor-030315	Dipodomys ordii	67.30	3.00e-126	445.00
IUUC-Ete-032408	Echinops telfairi	66.59	3.00e-120	425.00
IUUC-Eca-034244	Equus caballus	87.61	9.00e-97	345.00
IUUC-Fca-035391	Felis catus	87.61	7.00e-89	320.00
IUUC-Fal-036838	Ficedula albicollis	86.86	7.00e-96	343.00
IUUC-Gga-040619	Gallus gallus	86.44	2.00e-95	342.00
IUUC-Gac-041996	Gasterosteus aculeatus	64.29	1.00e-73	270.00
IUUC-Ggo-045481	Gorilla gorilla	97.39	0.00e+00	699.00
IUUC-Itr-048440	Ictidomys tridecemlineatus	90.17	9.00e-99	352.00
IUUC-Lch-050397	Latimeria chalumnae	83.05	8.00e-94	336.00
IUUC-Loc-052038	Lepisosteus oculatus	72.22	2.00e-76	278.00
IUUC-Laf-054126	Loxodonta africana	88.98	3.00e-99	354.00
IUUC-Mcc-055031	Macaca mulatta	89.90	9.00e-175	606.00
IUUC-Meu-056248	Macropus eugenii	71.20	2.00e-96	345.00
IUUC-Mga-059217	Meleagris gallopavo	86.70	2.00e-93	335.00
IUUC-Mmr-061581	Microcebus murinus	88.56	4.00e-98	350.00
IUUC-Mdo-062452	Monodelphis domestica	87.29	1.00e-96	345.00
IUUC-Mmu-063412	Mus musculus	87.71	4.00e-97	347.00
IUUC-Mpu-066479	Mustela putorius furo	88.46	2.00e-97	349.00
IUUC-Mlu-067723	Myotis lucifugus	87.71	3.00e-97	347.00
IUUC-Nle-069122	Nomascus leucogenys	98.31	3.00e-109	387.00
IUUC-Opr-070835	Ochotona princeps	84.12	2.00e-82	298.00
IUUC-Oan-073023	Ornithorhynchus anatinus	86.44	4.00e-93	334.00
IUUC-Ocu-073779	Oryctolagus cuniculus	86.75	2.00e-88	318.00
IUUC-Ola-086891	Oryzias latipes	63.14	2.00e-75	275.00
IUUC-Oga-087954	Otolemur garnettii	87.71	1.00e-96	345.00
IUUC-Oar-090006	Ovis aries	86.02	1.00e-93	335.00
IUUC-Ptr-090589	Pan troglodytes	98.73	1.00e-109	389.00
IUUC-Pan-091896	Papio anubis	93.35	0.00e+00	681.00
IUUC-Psi-093266	Pelodiscus sinensis	87.29	1.00e-96	346.00
IUUC-Pma-094265	Petromyzon marinus	76.39	4.00e-32	130.00
IUUC-Pab-098253	Pongo abelii	98.31	4.00e-109	387.00
IUUC-Pva-102753	Pteropus vampyrus	70.24	5.00e-109	387.00
IUUC-Rno-105964	Rattus norvegicus	87.61	8.00e-88	316.00
IUUC-Sha-107270	Sarcophilus harrisii	86.86	2.00e-95	342.00
IUUC-Tgu-116822	Taeniopygia guttata	88.14	3.00e-97	347.00
IUUC-Tvi-122341	Trichoderma virens	61.40	1.00e-15	75.50
IUUC-Ttr-128672	Tursiops truncatus	86.53	9.00e-97	346.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence