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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046526
Ensembl Protein ID ENSP00000284273.5
UniProt Accession Q8TF42; Q53GT5; Q53GT8; Q8NBV7; Q96IG9; Q96NZ2; UBS3B_HUMAN
Genbank Protein ID BAB85545.1; BAC11468.1; BAD96563.1; BAD96566.1; AAH07541.2; AAL16953.1
Protein Name Ubiquitin-associated and SH3 domain-containing protein B; Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; Tyrosine-protein phosphatase STS1/TULA2
Genbank Nucleotide ID AB075839; AK075203; AK222843; AK222846; BC007541; AF425252
Gene Name UBASH3B; KIAA1959; STS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000154127.9 ENST00000284273.5 ENSP00000284273.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 15159412; 17599067
Classification
Family E-value Score Start End
UBD/SH3 2.90e-21 76.8 255 318
UBD/Alpha-Helix/UBA 1.70e-08 36.0 39 76
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++e++qv+y+y++qnddeL+l  Gd++++   e+++++egW++g++ ++g++Gl+Pen+++k++
   Q: 255  NHETLQVIYPYTPQNDDELELVPGDFIFMSpmEQTSTSEGWIYGTSLTTGCSGLLPENYITKAD 318
           6899*********************************************************987 PP
   

   UBD/Alpha-Helix/UBA
   S: 5    dkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++l+ l +MGF+r +a++aL+++ + +++aA+++L+++
   Q: 39   SALDVLLSMGFPRARAQKALASTgGRSVQAACDWLFSH 76
           68999*******************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
 Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
Protein Sequence
(Fasta)
MAQYGHPSPL GMAAREELYS KVTPRRNRQQ RPGTIKHGSA LDVLLSMGFP RARAQKALAS 60
TGGRSVQAAC DWLFSHVGDP FLDDPLPREY VLYLRPTGPL AQKLSDFWQQ SKQICGKNKA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046526|UBD,UBA;UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGCCCACAA GGCTCCTTTT CCTTTTTGAT CCATTCAAAA ATTACTCATT GCAAATTCCC 60
GGACTGCTAG GCGAGGAGAG GGAAGGGGGC GGAGGAGACA GGGCTACTGC AGGCGCAGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046526|UBD,UBA;UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR009097--cNuc_Pdiesterase
IPR013078--His_Pase_superF_clade-1
IPR029033--His_PPase_superfam
IPR001452--SH3_domain
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS50002--SH3
PS50030--UBA
Pfam

PF00300--His_Phos_1
PF14604--SH3_9
PF00627--UBA
SMART

SM00326--SH3
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0004725--F:protein tyrosine phosphatase activity
GO:0045779--P:negative regulation of bone resorption
GO:0045671--P:negative regulation of osteoclast differentiation
GO:0090331--P:negative regulation of platelet aggregation
GO:0006469--P:negative regulation of protein kinase activity
GO:0009968--P:negative regulation of signal transduction
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
KEGG hsa:84959
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002126 Ailuropoda melanoleuca 97.64 0.00e+00 1276.00
IUUC-Apl-004080 Anas platyrhynchos 91.12 0.00e+00 1113.00
IUUC-Aca-004828 Anolis carolinensis 84.11 0.00e+00 1045.00
IUUC-Ame-011030 Astyanax mexicanus 74.35 0.00e+00 829.00
IUUC-Bta-012370 Bos taurus 97.82 0.00e+00 1200.00
IUUC-Bci-013728 Botrytis cinerea 28.14 7.00e-10 58.20
IUUC-Cel-018530 Caenorhabditis elegans 39.69 5.00e-51 194.00
IUUC-Cja-018758 Callithrix jacchus 99.54 0.00e+00 1298.00
IUUC-Cfa-020544 Canis familiaris 97.29 0.00e+00 1023.00
IUUC-Cpo-022044 Cavia porcellus 98.32 0.00e+00 1199.00
IUUC-Csa-024169 Chlorocebus sabaeus 99.54 0.00e+00 1296.00
IUUC-Cho-024498 Choloepus hoffmanni 80.67 0.00e+00 903.00
IUUC-Cin-025372 Ciona intestinalis 41.22 1.00e-57 218.00
IUUC-Csv-026379 Ciona savignyi 43.65 3.00e-75 275.00
IUUC-Cgl-026592 Colletotrichum gloeosporioides 29.08 3.00e-08 52.80
IUUC-Dre-027539 Danio rerio 74.07 0.00e+00 1009.00
IUUC-Dno-029808 Dasypus novemcinctus 97.52 0.00e+00 749.00
IUUC-Dor-030582 Dipodomys ordii 80.87 0.00e+00 1018.00
IUUC-Dme-032201 Drosophila melanogaster 38.61 3.00e-65 243.00
IUUC-Ete-032740 Echinops telfairi 78.67 0.00e+00 1033.00
IUUC-Eca-033743 Equus caballus 98.34 0.00e+00 1219.00
IUUC-Eeu-034505 Erinaceus europaeus 85.71 0.00e+00 700.00
IUUC-Fca-036519 Felis catus 97.53 0.00e+00 1307.00
IUUC-Fal-037295 Ficedula albicollis 89.13 0.00e+00 1105.00
IUUC-Gmo-038650 Gadus morhua 72.59 0.00e+00 929.00
IUUC-Gga-040179 Gallus gallus 90.45 0.00e+00 1190.00
IUUC-Gac-042180 Gasterosteus aculeatus 72.64 0.00e+00 942.00
IUUC-Ggo-044581 Gorilla gorilla 99.85 0.00e+00 1300.00
IUUC-Itr-048502 Ictidomys tridecemlineatus 97.48 0.00e+00 651.00
IUUC-Lch-049576 Latimeria chalumnae 80.40 0.00e+00 1016.00
IUUC-Loc-051854 Lepisosteus oculatus 79.53 0.00e+00 934.00
IUUC-Laf-054177 Loxodonta africana 97.34 0.00e+00 1278.00
IUUC-Mcc-055185 Macaca mulatta 99.54 0.00e+00 1296.00
IUUC-Meu-056216 Macropus eugenii 91.90 0.00e+00 1086.00
IUUC-Mga-059564 Meleagris gallopavo 90.77 0.00e+00 1109.00
IUUC-Mmr-060934 Microcebus murinus 98.92 0.00e+00 1291.00
IUUC-Mdo-062955 Monodelphis domestica 95.47 0.00e+00 1232.00
IUUC-Mmu-063301 Mus musculus 97.65 0.00e+00 1285.00
IUUC-Mpu-066416 Mustela putorius furo 97.84 0.00e+00 1307.00
IUUC-Mlu-067833 Myotis lucifugus 87.54 0.00e+00 1028.00
IUUC-Nle-069367 Nomascus leucogenys 99.23 0.00e+00 1293.00
IUUC-Opr-070879 Ochotona princeps 85.49 0.00e+00 755.00
IUUC-Ont-072540 Oreochromis niloticus 75.08 0.00e+00 961.00
IUUC-Oan-073124 Ornithorhynchus anatinus 90.79 0.00e+00 897.00
IUUC-Ocu-074796 Oryctolagus cuniculus 98.28 0.00e+00 1260.00
IUUC-Ola-087253 Oryzias latipes 73.64 0.00e+00 962.00
IUUC-Oga-088406 Otolemur garnettii 92.87 0.00e+00 1134.00
IUUC-Oar-090262 Ovis aries 97.84 0.00e+00 1284.00
IUUC-Ptr-091014 Pan troglodytes 99.85 0.00e+00 1300.00
IUUC-Pan-092684 Papio anubis 99.69 0.00e+00 1299.00
IUUC-Psi-093541 Pelodiscus sinensis 89.85 0.00e+00 1196.00
IUUC-Pma-094108 Petromyzon marinus 55.82 2.00e-152 532.00
IUUC-Pfo-097119 Poecilia formosa 72.40 0.00e+00 915.00
IUUC-Pab-097724 Pongo abelii 96.31 0.00e+00 1264.00
IUUC-Pca-100645 Procavia capensis 76.58 0.00e+00 726.00
IUUC-Pva-102322 Pteropus vampyrus 97.98 0.00e+00 1199.00
IUUC-Rno-105148 Rattus norvegicus 96.71 0.00e+00 1276.00
IUUC-Sha-106673 Sarcophilus harrisii 87.70 0.00e+00 1085.00
IUUC-Ssl-108385 Sclerotinia sclerotiorum 30.95 2.00e-08 53.10
IUUC-Sar-113746 Sorex araneus 76.99 4.00e-99 354.00
IUUC-Ssc-116425 Sus scrofa 97.84 0.00e+00 1217.00
IUUC-Tgu-116520 Taeniopygia guttata 88.92 0.00e+00 1151.00
IUUC-Tru-117750 Takifugu rubripes 67.92 0.00e+00 899.00
IUUC-Tsy-118975 Tarsius syrichta 97.98 0.00e+00 1174.00
IUUC-Tni-119830 Tetraodon nigroviridis 73.04 0.00e+00 921.00
IUUC-Tbe-127895 Tupaia belangeri 96.44 7.00e-136 478.00
IUUC-Ttr-129103 Tursiops truncatus 97.53 0.00e+00 1307.00
IUUC-Vpa-130720 Vicugna pacos 97.96 2.00e-113 403.00
IUUC-Xtr-132314 Xenopus tropicalis 83.59 0.00e+00 1113.00
Created Date 25-Jun-2017

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