iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063301

Ensembl Protein ID

ENSMUSP00000043865.8

UniProt Accession

Q8BGG7; Q3U8Z2; Q8BMW9; UBS3B_MOUSE

Genbank Protein ID

BAD06450.1; BAC25403.1; BAC28714.1; BAC29178.1; BAE21945.1; BAE30779.1; BAE30875.1; BAE32688.1; AAH53436.1

Protein Name

Ubiquitin-associated and SH3 domain-containing protein B; Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; Tyrosine-protein phosphatase STS1/TULA2

Genbank Nucleotide ID

AB075602; AK013361; AK034450; AK035764; AK133948; AK151895; AK152013; AK154576; BC053436

Gene Name

Ubash3b; Sts1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032020.15	ENSMUST00000044155.14	ENSMUSP00000043865.8
ENSMUSG00000032020.15	ENSMUST00000136530.7	ENSMUSP00000114176.1
ENSMUSG00000032020.15	ENSMUST00000129906.1	ENSMUSP00000134923.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
miRNAMap	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/SH3	SH3	23784775
UBD/Alpha-Helix/UBA	UBA	23784775

Classification

Family	E-value	Score	Start	End
UBD/SH3	2.00e-21	76.8	244	307
UBD/Alpha-Helix/UBA	1.20e-08	35.9	28	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++e++qv+y+y++qnddeL+l  Gd++++   e+++++egW++g++ ++g++Gl+Pen+++k++
   Q: 244  NHETLQVIYPYSPQNDDELELVPGDFIFMSpmEQTSTSEGWIYGTSLTTGCSGLLPENYITKAD 307
           6899*********************************************************987 PP

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++l+ l +MGF+r +a++aL+++ + +++aA+++L+++
   Q: 28   SALDVLLSMGFPRARAQKALASTgGRSVQAACDWLFSH 65
           68999*******************************97 PP

Organism

Mus musculus

Functional Description
(View)

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Protein Sequence
(Fasta)

MAAREELYSK VTPRRDRLQR PGTVKHGSAL DVLLSMGFPR ARAQKALAST GGRSVQAACD 60
WLFSHVGDPF LDDPLPREYV LYLRPTGPLA QKLSDFWQQS KQICGKNKAH NIFPHITLCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCTCCAGT GTCGTGGGAT GACAGCCTAA GGGAAGCCCC ACATTCTGCC AGCTGAGGAA 60
ACTGAGCCTA GGACAGCAGC ACATGATGTC ACATGCACCA AGAACTCCCT TGGAGATTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR009097--cNuc_Pdiesterase
IPR013078--His_Pase_superF_clade-1
IPR029033--His_PPase_superfam
IPR001452--SH3_domain
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50002--SH3
PS50030--UBA

Pfam

PF00300--His_Phos_1
PF14604--SH3_9
PF00627--UBA

SMART

SM00326--SH3
SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0004725--F:protein tyrosine phosphatase activity
GO:0038065--P:collagen-activated signaling pathway
GO:0038063--P:collagen-activated tyrosine kinase receptor signaling pathway
GO:0045779--P:negative regulation of bone resorption
GO:0045671--P:negative regulation of osteoclast differentiation
GO:0090331--P:negative regulation of platelet aggregation
GO:0006469--P:negative regulation of protein kinase activity
GO:0009968--P:negative regulation of signal transduction
GO:0035335--P:peptidyl-tyrosine dephosphorylation
GO:0030168--P:platelet activation
GO:0070527--P:platelet aggregation
GO:0045670--P:regulation of osteoclast differentiation
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol

KEGG

mmu:72828

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002126	Ailuropoda melanoleuca	96.06	0.00e+00	1259.00
IUUC-Apl-004080	Anas platyrhynchos	90.45	0.00e+00	1107.00
IUUC-Aca-004828	Anolis carolinensis	84.08	0.00e+00	1044.00
IUUC-Ame-011030	Astyanax mexicanus	73.80	0.00e+00	829.00
IUUC-Bgr-012101	Blumeria graminis	29.85	7.00e-11	61.20
IUUC-Bta-012370	Bos taurus	96.81	0.00e+00	1191.00
IUUC-Bci-013728	Botrytis cinerea	27.71	2.00e-09	56.60
IUUC-Cel-018530	Caenorhabditis elegans	40.08	6.00e-52	197.00
IUUC-Cja-018758	Callithrix jacchus	97.49	0.00e+00	1258.00
IUUC-Cfa-020544	Canis familiaris	96.32	0.00e+00	1018.00
IUUC-Cpo-022044	Cavia porcellus	97.14	0.00e+00	1191.00
IUUC-Csa-024169	Chlorocebus sabaeus	97.49	0.00e+00	1257.00
IUUC-Cho-024498	Choloepus hoffmanni	79.83	0.00e+00	900.00
IUUC-Cin-025372	Ciona intestinalis	41.60	1.00e-58	221.00
IUUC-Csv-026379	Ciona savignyi	43.65	6.00e-75	274.00
IUUC-Cgl-026592	Colletotrichum gloeosporioides	29.59	3.00e-09	55.80
IUUC-Cme-027186	Cyanidioschyzon merolae	27.47	3.00e-08	52.40
IUUC-Dre-027539	Danio rerio	73.91	0.00e+00	1006.00
IUUC-Dno-029808	Dasypus novemcinctus	96.29	0.00e+00	748.00
IUUC-Dor-030582	Dipodomys ordii	80.72	0.00e+00	1009.00
IUUC-Dme-032201	Drosophila melanogaster	38.89	9.00e-66	245.00
IUUC-Ete-032740	Echinops telfairi	77.59	0.00e+00	1013.00
IUUC-Eca-033743	Equus caballus	97.35	0.00e+00	1211.00
IUUC-Eeu-034505	Erinaceus europaeus	85.20	0.00e+00	700.00
IUUC-Fca-036519	Felis catus	96.39	0.00e+00	1274.00
IUUC-Fal-037295	Ficedula albicollis	88.80	0.00e+00	1107.00
IUUC-Gmo-038650	Gadus morhua	72.27	0.00e+00	930.00
IUUC-Gga-040179	Gallus gallus	89.67	0.00e+00	1186.00
IUUC-Gac-042180	Gasterosteus aculeatus	72.14	0.00e+00	938.00
IUUC-Ggo-044581	Gorilla gorilla	97.81	0.00e+00	1261.00
IUUC-Hsa-046526	Homo sapiens	97.65	0.00e+00	1261.00
IUUC-Itr-048502	Ictidomys tridecemlineatus	95.90	0.00e+00	646.00
IUUC-Lch-049576	Latimeria chalumnae	80.56	0.00e+00	1016.00
IUUC-Loc-051854	Lepisosteus oculatus	79.03	0.00e+00	932.00
IUUC-Laf-054177	Loxodonta africana	96.55	0.00e+00	1269.00
IUUC-Mcc-055185	Macaca mulatta	97.65	0.00e+00	1260.00
IUUC-Meu-056216	Macropus eugenii	91.60	0.00e+00	1065.00
IUUC-Mga-059564	Meleagris gallopavo	90.44	0.00e+00	1110.00
IUUC-Mmr-060934	Microcebus murinus	97.96	0.00e+00	1262.00
IUUC-Mdo-062955	Monodelphis domestica	94.69	0.00e+00	1224.00
IUUC-Mpu-066416	Mustela putorius furo	96.71	0.00e+00	1275.00
IUUC-Mlu-067833	Myotis lucifugus	87.04	0.00e+00	1024.00
IUUC-Nle-069367	Nomascus leucogenys	97.18	0.00e+00	1253.00
IUUC-Opr-070879	Ochotona princeps	84.82	0.00e+00	754.00
IUUC-Ont-072540	Oreochromis niloticus	74.14	0.00e+00	957.00
IUUC-Oan-073124	Ornithorhynchus anatinus	91.21	0.00e+00	898.00
IUUC-Ocu-074796	Oryctolagus cuniculus	97.02	0.00e+00	1251.00
IUUC-Ola-087253	Oryzias latipes	72.67	0.00e+00	953.00
IUUC-Oga-088406	Otolemur garnettii	92.04	0.00e+00	1129.00
IUUC-Oar-090262	Ovis aries	96.71	0.00e+00	1251.00
IUUC-Ptr-091014	Pan troglodytes	97.81	0.00e+00	1261.00
IUUC-Pan-092684	Papio anubis	97.65	0.00e+00	1260.00
IUUC-Psi-093541	Pelodiscus sinensis	90.77	0.00e+00	1185.00
IUUC-Pma-094108	Petromyzon marinus	55.42	4.00e-152	531.00
IUUC-Pfo-097119	Poecilia formosa	72.12	0.00e+00	910.00
IUUC-Pab-097724	Pongo abelii	94.69	0.00e+00	1226.00
IUUC-Pca-100645	Procavia capensis	75.97	0.00e+00	724.00
IUUC-Pva-102322	Pteropus vampyrus	96.81	0.00e+00	1188.00
IUUC-Rno-105148	Rattus norvegicus	98.75	0.00e+00	1295.00
IUUC-Sha-106673	Sarcophilus harrisii	87.22	0.00e+00	1080.00
IUUC-Ssl-108385	Sclerotinia sclerotiorum	30.36	3.00e-08	52.40
IUUC-Sar-113746	Sorex araneus	76.99	4.00e-99	354.00
IUUC-Ssc-116425	Sus scrofa	97.35	0.00e+00	1212.00
IUUC-Tgu-116520	Taeniopygia guttata	88.73	0.00e+00	1153.00
IUUC-Tru-117750	Takifugu rubripes	67.57	0.00e+00	898.00
IUUC-Tsy-118975	Tarsius syrichta	96.81	0.00e+00	1166.00
IUUC-Tni-119830	Tetraodon nigroviridis	72.10	0.00e+00	913.00
IUUC-Tbe-127895	Tupaia belangeri	96.73	4.00e-133	468.00
IUUC-Ttr-129103	Tursiops truncatus	96.08	0.00e+00	1270.00
IUUC-Uma-129616	Ustilago maydis	24.39	7.00e-05	40.80
IUUC-Vpa-130720	Vicugna pacos	96.94	1.00e-112	400.00
IUUC-Xtr-132314	Xenopus tropicalis	82.66	0.00e+00	1106.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence