iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046332

UUCD1 version

UUC-HoS-00299

Ensembl Protein ID

ENSP00000284551.6

UniProt Accession

Q96F44; A6NKE2; B2RB82; B3KUS3; B4DX88; Q5VSU1; Q8NCA6; Q9C022; TRI11_HUMAN

Genbank Protein ID

AAM63957.1; BAC11254.1; BAG37129.1; BAG53535.1; BAG63300.1; CAH71671.1; CAH71672.1; AAH11629.1; AAH69227.1; AAG53498.1

Protein Name

E3 ubiquitin-protein ligase TRIM11; Protein BIA1; RING finger protein 92; RING-type E3 ubiquitin transferase TRIM11; Tripartite motif-containing protein 11

Genbank Nucleotide ID

AF327056; AK074866; AK314539; AK097825; AK301859; AL670729; AL670729; BC011629; BC069227; AF220125

Gene Name

TRIM11; RNF92

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000154370.14	ENST00000493030.6	ENSP00000473360.1
ENSG00000154370.14	ENST00000284551.10	ENSP00000284551.6
ENSG00000154370.14	ENST00000602582.5	ENSP00000473574.1
ENSG00000154370.14	ENST00000366699.3	ENSP00000355660.3
ENSG00000154370.14	ENST00000602308.1	ENSP00000473579.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090; 18628401; 16904669

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	7.50e-06	27.6	12	71
E3 activity/RING/RING	9.40e-08	34.1	16	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl..asggk..tcPvtrqplteedlvPnltl 61
           ee  C+I l+ ++dPv++ +G+ + r++I+++    +      cP +r+   +++l Pn  l
   Q: 12   EEATCAICLDYFTDPVMTDCGHNFCRECIRRCWgqPE--GpyACPECRELSPQRNLRPNRPL 71
           7889***************************995333..346*****************866 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           CaiCl+ f d p+ ++CgH f+++C+  +w     +  +   CP Cr
   Q: 16   CAICLDYFTD-PVMTDCGHNFCRECIrRCW----GQPEGPYACPECR 57
           **********.999************99**....66789999****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Protein Sequence
(Fasta)

MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECRELS 60
PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA AFCGDELRLL CAACERSGEH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCGCCTC GGCTCCTCTT CCTGCCGGCA TCCGGGATCC CTACGTCCCG CGTCCCCCGA 60
GCGCTCGGAG CCTACGCGCC CAGCGCTACC GAAACCCAGA GTCCTGCGCC CTGGAGTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0050768--P:negative regulation of neurogenesis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0046598--P:positive regulation of viral entry into host cell

KEGG

hsa:81559

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001800	Ailuropoda melanoleuca	73.61	7.00e-169	587.00
IUUC-Bta-012332	Bos taurus	91.88	0.00e+00	794.00
IUUC-Cja-019969	Callithrix jacchus	84.40	0.00e+00	697.00
IUUC-Cfa-020491	Canis familiaris	91.45	0.00e+00	802.00
IUUC-Cpo-021936	Cavia porcellus	89.53	0.00e+00	767.00
IUUC-Csa-024151	Chlorocebus sabaeus	98.93	0.00e+00	795.00
IUUC-Cho-024990	Choloepus hoffmanni	78.67	4.00e-116	410.00
IUUC-Dno-029580	Dasypus novemcinctus	79.67	0.00e+00	640.00
IUUC-Ete-032556	Echinops telfairi	69.97	1.00e-114	406.00
IUUC-Eca-033612	Equus caballus	75.27	1.00e-136	479.00
IUUC-Fca-035821	Felis catus	89.76	8.00e-152	529.00
IUUC-Ggo-044629	Gorilla gorilla	99.57	0.00e+00	800.00
IUUC-Itr-047946	Ictidomys tridecemlineatus	93.80	0.00e+00	778.00
IUUC-Lch-049738	Latimeria chalumnae	37.78	1.00e-74	273.00
IUUC-Laf-054350	Loxodonta africana	76.72	1.00e-147	516.00
IUUC-Mcc-055827	Macaca mulatta	97.65	0.00e+00	776.00
IUUC-Meu-056122	Macropus eugenii	72.81	0.00e+00	660.00
IUUC-Mmr-061700	Microcebus murinus	92.72	0.00e+00	785.00
IUUC-Mdo-062921	Monodelphis domestica	63.89	8.00e-167	580.00
IUUC-Mmu-063762	Mus musculus	89.53	0.00e+00	740.00
IUUC-Mpu-065873	Mustela putorius furo	91.67	0.00e+00	806.00
IUUC-Mlu-067379	Myotis lucifugus	69.64	1.00e-173	603.00
IUUC-Nle-069440	Nomascus leucogenys	98.94	0.00e+00	796.00
IUUC-Opr-070901	Ochotona princeps	81.62	2.00e-180	625.00
IUUC-Oan-073401	Ornithorhynchus anatinus	45.08	4.00e-91	328.00
IUUC-Ocu-074038	Oryctolagus cuniculus	74.57	3.00e-164	571.00
IUUC-Oga-088948	Otolemur garnettii	89.21	0.00e+00	765.00
IUUC-Oar-090242	Ovis aries	85.15	0.00e+00	748.00
IUUC-Ptr-090615	Pan troglodytes	89.19	4.00e-110	391.00
IUUC-Pan-092626	Papio anubis	99.36	0.00e+00	797.00
IUUC-Pab-097895	Pongo abelii	92.95	0.00e+00	803.00
IUUC-Pca-100435	Procavia capensis	89.51	0.00e+00	751.00
IUUC-Pva-102288	Pteropus vampyrus	81.84	0.00e+00	679.00
IUUC-Pgr-103696	Puccinia graminis	34.78	2.00e-06	45.80
IUUC-Rno-105938	Rattus norvegicus	90.17	0.00e+00	750.00
IUUC-Sha-107354	Sarcophilus harrisii	75.11	0.00e+00	675.00
IUUC-Tbe-127733	Tupaia belangeri	95.48	0.00e+00	783.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence