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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046064
Ensembl Protein ID ENSP00000284694.7
UniProt Accession Q96M02; B9EIQ9; Q5JRP6; Q5T023; Q8NCV5; Q8WU75; CJ090_HUMAN
Genbank Protein ID CAI12409.1; CAI12409.1; CAI40680.1; CAI40680.1; CAI40684.1; AAH21140.1; AAI40899.1; AAI46870.1; BAB71512.1; AAM20911.1
Protein Name Centrosomal protein C10orf90; Fragile-site associated tumor suppressor homolog
Genbank Nucleotide ID AL583860; AL589787; AL589787; AL583860; AL589787; BC021140; BC140898; BC146869; AK057500; AF435960
Gene Name C10orf90; FATS
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000154493.17 ENST00000424927.5 ENSP00000411609.1
ENSG00000154493.17 ENST00000356858.7 ENSP00000349318.3
ENSG00000154493.17 ENST00000463082.1 ENSP00000474615.1
ENSG00000154493.17 ENST00000284694.11 ENSP00000284694.7
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircRNADbCircNetmicroRNA
TRANSFACTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
iRefIndexMentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 65.19 0.00e+00 808.00 IUUC-Mmu-063159
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.
 Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia.
Protein Sequence
(Fasta)
MLKLSGEGLR DSYHSRRDQI ALKNLQSDVT EAKSDFTKET LASQNTKMIS SIVISQMIDE 60
NKSRENRASL PLPCAIAQSR AHHAKQSLAN RSGVNIHRAF ALLPGRLGIP APSDERGPEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046064|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCAGGGGTA TGCTGCCCGC TACACAGAAA CGGCCGTGCA TCGGACTTTC CAGATAAAAA 60
CATTTAGTAC AGAGTTGAAA AACCATGTGA TGGTCATGGA TTTTGTGAAG AGTAACTGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046064|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0043--Tumor suppressor
Interpro

IPR029299--ALMS_motif
IPR029561--C10orf90
Pfam

PF15309--ALMS_motif
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0051393--F:alpha-actinin binding
GO:0042826--F:histone deacetylase binding
KEGG hsa:118611
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001833 Ailuropoda melanoleuca 67.77 0.00e+00 825.00
IUUC-Apl-003559 Anas platyrhynchos 72.73 1.00e-39 155.00
IUUC-Aca-005337 Anolis carolinensis 43.91 2.00e-50 192.00
IUUC-Ame-011899 Astyanax mexicanus 71.25 3.00e-24 102.00
IUUC-Bta-013353 Bos taurus 68.08 0.00e+00 825.00
IUUC-Cja-019286 Callithrix jacchus 87.50 0.00e+00 1160.00
IUUC-Cfa-020500 Canis familiaris 61.57 0.00e+00 652.00
IUUC-Cpo-022008 Cavia porcellus 69.24 0.00e+00 926.00
IUUC-Csa-023064 Chlorocebus sabaeus 92.98 0.00e+00 1264.00
IUUC-Cho-024514 Choloepus hoffmanni 51.29 3.00e-170 592.00
IUUC-Dno-029300 Dasypus novemcinctus 51.72 8.00e-89 320.00
IUUC-Dor-030427 Dipodomys ordii 47.92 4.00e-103 369.00
IUUC-Ete-032875 Echinops telfairi 46.68 2.00e-77 283.00
IUUC-Eca-034005 Equus caballus 74.57 0.00e+00 969.00
IUUC-Eeu-035334 Erinaceus europaeus 57.59 1.00e-43 171.00
IUUC-Fca-036078 Felis catus 66.41 0.00e+00 811.00
IUUC-Fal-037368 Ficedula albicollis 66.21 4.00e-37 148.00
IUUC-Gga-041090 Gallus gallus 70.59 2.00e-39 154.00
IUUC-Ggo-045310 Gorilla gorilla 98.12 0.00e+00 1329.00
IUUC-Itr-048926 Ictidomys tridecemlineatus 67.58 0.00e+00 868.00
IUUC-Loc-052489 Lepisosteus oculatus 72.50 5.00e-21 92.40
IUUC-Laf-053440 Loxodonta africana 62.50 0.00e+00 712.00
IUUC-Mcc-055047 Macaca mulatta 93.25 0.00e+00 1260.00
IUUC-Meu-056566 Macropus eugenii 53.16 1.00e-169 589.00
IUUC-Mga-059641 Meleagris gallopavo 38.23 1.00e-80 294.00
IUUC-Mmr-061488 Microcebus murinus 69.66 1.00e-158 553.00
IUUC-Mdo-062611 Monodelphis domestica 48.00 8.00e-158 550.00
IUUC-Mmu-063159 Mus musculus 64.86 0.00e+00 745.00
IUUC-Mpu-066208 Mustela putorius furo 62.02 0.00e+00 659.00
IUUC-Mlu-066943 Myotis lucifugus 58.49 1.00e-100 359.00
IUUC-Nle-069500 Nomascus leucogenys 94.83 0.00e+00 1266.00
IUUC-Opr-070781 Ochotona princeps 60.60 0.00e+00 722.00
IUUC-Ocu-074617 Oryctolagus cuniculus 72.03 7.00e-94 336.00
IUUC-Ola-086910 Oryzias latipes 70.13 2.00e-21 94.00
IUUC-Oga-089026 Otolemur garnettii 72.73 0.00e+00 911.00
IUUC-Oar-089197 Ovis aries 68.28 0.00e+00 852.00
IUUC-Ptr-090985 Pan troglodytes 98.57 0.00e+00 1326.00
IUUC-Pan-092432 Papio anubis 92.96 0.00e+00 1261.00
IUUC-Psi-093653 Pelodiscus sinensis 45.43 2.00e-138 486.00
IUUC-Pab-098049 Pongo abelii 94.55 0.00e+00 726.00
IUUC-Pca-101082 Procavia capensis 80.85 2.00e-65 244.00
IUUC-Pva-102848 Pteropus vampyrus 63.32 0.00e+00 778.00
IUUC-Rno-105154 Rattus norvegicus 63.68 0.00e+00 737.00
IUUC-Sha-107583 Sarcophilus harrisii 42.24 3.00e-88 319.00
IUUC-Ssc-116095 Sus scrofa 68.25 0.00e+00 857.00
IUUC-Tsy-118864 Tarsius syrichta 69.35 0.00e+00 743.00
IUUC-Tbe-127637 Tupaia belangeri 71.98 0.00e+00 897.00
IUUC-Ttr-128508 Tursiops truncatus 70.91 0.00e+00 842.00
Created Date 25-Jun-2017

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