iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16713563; 16307923; 16627869; 19037095

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.38	13.0	922	961

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+ C  + kd  +++ C Hvf+++C+  ++        ++ +CP C+
   Q: 922  CPCCNMRKKD-AVLTKCFHVFCFECVkTRY------DTRQRKCPKCN 961
           9999555566.888************9999......999*******6 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Protein Sequence
(Fasta)

MSGIGNKRAA GEPGTSMPPE KKAAVEDSGT TVETIKLGGV SSTEELDIRT LQTKNRKLAE 60
MLDQRQAIED ELREHIEKLE RRQATDDASL LIVNRYWSQF DENIRIILKR YDLEQGLGDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGTTCTG CCTTGTCTCC GCCGCGGGTC AGGGGTGAGA GCTGGAATCT CTGCACGGGC 60
CTTGGTGAGT AACTGCTGCG AGTTCTGTTC CCGCGCGGCG CCAGTTCAAA GAACTTAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015422--PyrdxlP-dep_Trfase_sub2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0033503--C:HULC complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0002039--F:p53 binding
GO:0003713--F:transcription coactivator activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0030336--P:negative regulation of cell migration
GO:1900364--P:negative regulation of mRNA polyadenylation
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:0031062--P:positive regulation of histone methylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:56254

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001976	Ailuropoda melanoleuca	98.26	0.00e+00	1652.00
IUUC-Apl-003407	Anas platyrhynchos	87.54	0.00e+00	943.00
IUUC-Aca-004246	Anolis carolinensis	87.37	0.00e+00	928.00
IUUC-Ago-007988	Ashbya gossypii	31.69	6.00e-15	76.30
IUUC-Acl-008319	Aspergillus clavatus	25.85	3.00e-14	73.90
IUUC-Aor-010142	Aspergillus oryzae	28.62	2.00e-15	78.20
IUUC-Ate-010547	Aspergillus terreus	26.15	2.00e-14	74.30
IUUC-Ame-011916	Astyanax mexicanus	77.93	2.00e-143	503.00
IUUC-Bta-012357	Bos taurus	98.05	0.00e+00	1615.00
IUUC-Bci-013926	Botrytis cinerea	44.19	5.00e-08	53.50
IUUC-Bdi-015006	Brachypodium distachyon	26.46	6.00e-24	106.00
IUUC-Cel-018659	Caenorhabditis elegans	34.41	8.00e-40	159.00
IUUC-Cja-019244	Callithrix jacchus	98.88	0.00e+00	1028.00
IUUC-Cfa-020320	Canis familiaris	98.46	0.00e+00	1649.00
IUUC-Cpo-021617	Cavia porcellus	95.29	0.00e+00	1664.00
IUUC-Csa-023509	Chlorocebus sabaeus	100.00	0.00e+00	1619.00
IUUC-Cho-024616	Choloepus hoffmanni	81.49	0.00e+00	971.00
IUUC-Cme-027134	Cyanidioschyzon merolae	39.06	1.00e-13	71.60
IUUC-Dno-029537	Dasypus novemcinctus	97.61	0.00e+00	1021.00
IUUC-Dor-030250	Dipodomys ordii	95.90	0.00e+00	1541.00
IUUC-Dse-031300	Dothistroma septosporum	38.46	2.00e-15	77.80
IUUC-Ete-033164	Echinops telfairi	94.26	0.00e+00	1214.00
IUUC-Eca-033347	Equus caballus	98.26	0.00e+00	1612.00
IUUC-Eeu-034801	Erinaceus europaeus	93.61	0.00e+00	635.00
IUUC-Fca-036024	Felis catus	98.56	0.00e+00	1677.00
IUUC-Fal-037622	Ficedula albicollis	88.43	0.00e+00	949.00
IUUC-Gmo-039446	Gadus morhua	77.55	4.00e-132	466.00
IUUC-Ggr-040117	Gaeumannomyces graminis	45.28	2.00e-11	64.30
IUUC-Gga-040412	Gallus gallus	89.48	0.00e+00	902.00
IUUC-Gac-042205	Gasterosteus aculeatus	60.68	6.00e-142	498.00
IUUC-Ggo-044703	Gorilla gorilla	99.90	0.00e+00	1619.00
IUUC-Itr-048298	Ictidomys tridecemlineatus	98.54	0.00e+00	1597.00
IUUC-Lch-049505	Latimeria chalumnae	74.86	0.00e+00	705.00
IUUC-Loc-051951	Lepisosteus oculatus	63.47	7.00e-112	398.00
IUUC-Lma-053312	Leptosphaeria maculans	28.71	6.00e-15	76.30
IUUC-Laf-054122	Loxodonta africana	96.93	0.00e+00	1602.00
IUUC-Mcc-054647	Macaca mulatta	100.00	0.00e+00	1619.00
IUUC-Meu-056559	Macropus eugenii	92.02	0.00e+00	1454.00
IUUC-Mpo-057568	Magnaporthe poae	45.28	2.00e-11	64.30
IUUC-Mga-059731	Meleagris gallopavo	95.18	2.00e-173	603.00
IUUC-Mmr-061495	Microcebus murinus	98.77	0.00e+00	1664.00
IUUC-Mdo-062599	Monodelphis domestica	93.59	0.00e+00	973.00
IUUC-Mmu-063278	Mus musculus	97.42	0.00e+00	1020.00
IUUC-Mpu-065910	Mustela putorius furo	98.15	0.00e+00	1654.00
IUUC-Mlu-067040	Myotis lucifugus	97.54	0.00e+00	1590.00
IUUC-Ncr-068695	Neurospora crassa	27.31	3.00e-12	67.00
IUUC-Nle-069058	Nomascus leucogenys	99.81	0.00e+00	1036.00
IUUC-Opr-071149	Ochotona princeps	96.61	0.00e+00	1006.00
IUUC-Ont-072543	Oreochromis niloticus	75.00	1.00e-133	470.00
IUUC-Oan-072996	Ornithorhynchus anatinus	96.97	0.00e+00	646.00
IUUC-Ocu-074773	Oryctolagus cuniculus	98.36	0.00e+00	1592.00
IUUC-Ola-087287	Oryzias latipes	63.20	0.00e+00	887.00
IUUC-Olu-087683	Ostreococcus lucimarinus	36.36	1.00e-13	68.60
IUUC-Oga-088961	Otolemur garnettii	98.67	0.00e+00	1637.00
IUUC-Oar-089755	Ovis aries	97.95	0.00e+00	1607.00
IUUC-Ptr-091602	Pan troglodytes	100.00	0.00e+00	1619.00
IUUC-Pan-092263	Papio anubis	100.00	0.00e+00	1619.00
IUUC-Psi-093554	Pelodiscus sinensis	89.25	0.00e+00	947.00
IUUC-Pab-098598	Pongo abelii	99.79	0.00e+00	1617.00
IUUC-Pca-100157	Procavia capensis	96.15	0.00e+00	996.00
IUUC-Pva-102720	Pteropus vampyrus	97.64	0.00e+00	1578.00
IUUC-Rno-104996	Rattus norvegicus	97.05	0.00e+00	1015.00
IUUC-Sha-107000	Sarcophilus harrisii	94.83	0.00e+00	964.00
IUUC-Sja-107993	Schizosaccharomyces japonicus	45.00	2.00e-12	68.20
IUUC-Spo-108304	Schizosaccharomyces pombe	43.08	8.00e-15	75.90
IUUC-Sar-113349	Sorex araneus	97.07	0.00e+00	941.00
IUUC-Ssc-115723	Sus scrofa	98.26	0.00e+00	1615.00
IUUC-Tgu-116549	Taeniopygia guttata	88.07	0.00e+00	876.00
IUUC-Tsy-118808	Tarsius syrichta	96.08	0.00e+00	1180.00
IUUC-Ttr-128266	Tursiops truncatus	97.85	0.00e+00	1599.00
IUUC-Vpa-130237	Vicugna pacos	98.16	0.00e+00	1654.00
IUUC-Xtr-132589	Xenopus tropicalis	76.33	0.00e+00	710.00
IUUC-Yli-134445	Yarrowia lipolytica	39.06	9.00e-13	68.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence