iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	12121982

Classification

Family	E-value	Score	Start	End
E2/UBC	2.90e-37	127.9	6	141

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel +l+k+ p++++   +d++++  w++l+l p++ pY+ ++F l+i+fp++YP+kPP+++f+tki+hPn++e+G vCl ++ ++
   Q: 6    RVAKELDDLSKELPPYLRHLSSDDANVLVWHMLLL-PDQLPYRLKAFGLRIDFPREYPLKPPTLRFTTKIYHPNISEDGLVCLPLI-ST 92
           899********************************.**************************************************.5* PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           e+W+p ++  +vl +++ l+++pn e+p++ e a+ll++++e+++kk++
   Q: 93   ENWKPYTKAYQVLEALNILVSRPNLEEPVRLELADLLTQDPEMFRKKAE 141
           **********************************************986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Protein Sequence
(Fasta)

MTASKRVAKE LDDLSKELPP YLRHLSSDDA NVLVWHMLLL PDQLPYRLKA FGLRIDFPRE 60
YPLKPPTLRF TTKIYHPNIS EDGLVCLPLI STENWKPYTK AYQVLEALNI LVSRPNLEEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAGTTAAG GGAGCGGTCC TTGGAGGGCA TAAAGTCTAC ACTGATCCCC AATCTCTTTT 60
AGGATGGGGT ACTAGACCCA CAAAGGCAAA GTGATTTGGC CCAGGACTCT GAGAATTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

rno:295704

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001818	Ailuropoda melanoleuca	69.28	3.00e-61	226.00
IUUC-Apl-003318	Anas platyrhynchos	50.00	1.00e-29	122.00
IUUC-Aca-005234	Anolis carolinensis	50.00	2.00e-29	121.00
IUUC-Ame-011622	Astyanax mexicanus	49.34	3.00e-30	124.00
IUUC-Bta-012539	Bos taurus	68.63	2.00e-59	220.00
IUUC-Cel-018332	Caenorhabditis elegans	42.76	1.00e-34	138.00
IUUC-Cja-019456	Callithrix jacchus	75.16	7.00e-67	245.00
IUUC-Cfa-021275	Canis familiaris	72.55	1.00e-63	234.00
IUUC-Cpo-022261	Cavia porcellus	67.97	5.00e-60	223.00
IUUC-Csa-023794	Chlorocebus sabaeus	74.17	3.00e-64	236.00
IUUC-Cho-024821	Choloepus hoffmanni	70.83	1.00e-56	211.00
IUUC-Cin-025130	Ciona intestinalis	47.71	3.00e-30	124.00
IUUC-Csv-026183	Ciona savignyi	47.68	2.00e-28	118.00
IUUC-Dre-027710	Danio rerio	50.00	2.00e-32	131.00
IUUC-Dno-029632	Dasypus novemcinctus	70.59	2.00e-61	228.00
IUUC-Dor-030595	Dipodomys ordii	59.48	1.00e-47	181.00
IUUC-Dme-031814	Drosophila melanogaster	48.37	1.00e-38	152.00
IUUC-Ete-032754	Echinops telfairi	50.66	2.00e-32	131.00
IUUC-Eca-033746	Equus caballus	70.59	3.00e-61	227.00
IUUC-Eeu-034942	Erinaceus europaeus	50.00	2.00e-32	130.00
IUUC-Fca-035417	Felis catus	69.93	6.00e-61	226.00
IUUC-Fal-036820	Ficedula albicollis	50.35	2.00e-29	121.00
IUUC-Gmo-038480	Gadus morhua	47.55	1.00e-26	112.00
IUUC-Gga-041039	Gallus gallus	50.66	2.00e-32	131.00
IUUC-Gac-041571	Gasterosteus aculeatus	46.05	1.00e-27	115.00
IUUC-Ggo-045537	Gorilla gorilla	73.20	1.00e-64	238.00
IUUC-Hsa-045943	Homo sapiens	73.86	1.00e-65	241.00
IUUC-Itr-048889	Ictidomys tridecemlineatus	72.55	4.00e-62	229.00
IUUC-Lch-049699	Latimeria chalumnae	51.75	3.00e-21	94.00
IUUC-Loc-052000	Lepisosteus oculatus	50.00	4.00e-31	127.00
IUUC-Laf-053524	Loxodonta africana	64.71	4.00e-52	196.00
IUUC-Mcc-054818	Macaca mulatta	74.17	7.00e-64	235.00
IUUC-Meu-055936	Macropus eugenii	57.27	1.00e-32	130.00
IUUC-Mga-060134	Meleagris gallopavo	49.33	8.00e-29	119.00
IUUC-Mmr-060799	Microcebus murinus	75.00	7.00e-65	238.00
IUUC-Mdo-062043	Monodelphis domestica	41.62	3.00e-27	114.00
IUUC-Mmu-063359	Mus musculus	88.89	1.00e-77	281.00
IUUC-Mpu-066122	Mustela putorius furo	67.57	8.00e-58	215.00
IUUC-Mlu-067283	Myotis lucifugus	71.24	7.00e-61	225.00
IUUC-Nle-069829	Nomascus leucogenys	74.51	4.00e-66	243.00
IUUC-Opr-071062	Ochotona princeps	75.16	6.00e-65	239.00
IUUC-Ont-072036	Oreochromis niloticus	50.00	6.00e-32	129.00
IUUC-Oan-073297	Ornithorhynchus anatinus	65.00	2.00e-33	133.00
IUUC-Ocu-074709	Oryctolagus cuniculus	75.17	3.00e-61	226.00
IUUC-Ola-086994	Oryzias latipes	49.31	8.00e-38	149.00
IUUC-Oga-088256	Otolemur garnettii	73.03	2.00e-63	234.00
IUUC-Oar-089370	Ovis aries	67.59	2.00e-55	207.00
IUUC-Ptr-091324	Pan troglodytes	73.86	1.00e-65	241.00
IUUC-Pan-092601	Papio anubis	73.79	1.00e-61	228.00
IUUC-Psi-093989	Pelodiscus sinensis	51.72	5.00e-33	132.00
IUUC-Pma-094445	Petromyzon marinus	46.76	6.00e-26	109.00
IUUC-Pfo-097407	Poecilia formosa	51.97	2.00e-34	138.00
IUUC-Pab-098184	Pongo abelii	75.16	3.00e-67	246.00
IUUC-Pca-101080	Procavia capensis	65.97	1.00e-54	205.00
IUUC-Pva-102211	Pteropus vampyrus	53.59	4.00e-41	160.00
IUUC-Sha-107162	Sarcophilus harrisii	57.52	1.00e-47	181.00
IUUC-Sar-113240	Sorex araneus	50.35	2.00e-29	120.00
IUUC-Ssc-115506	Sus scrofa	72.55	9.00e-63	232.00
IUUC-Tgu-117352	Taeniopygia guttata	50.00	1.00e-29	121.00
IUUC-Tru-117653	Takifugu rubripes	49.34	2.00e-31	127.00
IUUC-Tsy-118811	Tarsius syrichta	60.42	8.00e-47	179.00
IUUC-Tni-120844	Tetraodon nigroviridis	49.67	4.00e-41	160.00
IUUC-Tbe-127294	Tupaia belangeri	50.69	5.00e-30	123.00
IUUC-Ttr-129266	Tursiops truncatus	73.86	7.00e-65	238.00
IUUC-Vpa-130649	Vicugna pacos	70.71	2.00e-37	146.00
IUUC-Xtr-132650	Xenopus tropicalis	50.00	2.00e-32	130.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence