iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000156787.16	ENST00000287380.5	ENSP00000287380.1
ENSG00000156787.16	ENST00000519418.5	ENSP00000430927.1
ENSG00000156787.16	ENST00000327098.9	ENSP00000312701.5
ENSG00000156787.16	ENST00000522420.5	ENSP00000429334.1
ENSG00000156787.16	ENST00000521676.5	ENSP00000430628.1
ENSG00000156787.16	ENST00000524307.5	ENSP00000440772.1
ENSG00000156787.16	ENST00000522276.1	ENSP00000428891.1
ENSG00000156787.16	ENST00000521914.1	ENSP00000432525.1
ENSG00000156787.16	ENST00000518805.5	ENSP00000429494.1
ENSG00000156787.16	ENST00000518577.1	ENSP00000432064.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-06	29.9	124	157

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtg 33
           gH++sv++++   s+++ ++ s D t ++WDl+t+
   Q: 124  GHESSVFSISVhaSGKYAITTSSD-TAQLWDLDTF 157
           8*********99888*****9999.9*****9986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MQSTDLGNKE SGKIWHRKPS PATRDGIIVN IIHNTSDYHP KVLRFLNVAF DGTGDCLIAG 60
DHQGNIYVFD LHGNRFNLVQ RTAQACTALA FNLRRKSEFL VALADYSIKC FDTVTKELVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCTGAAAGC GATAAAGGAA GGCTTCGGGC CAGAGGAAGA GGTAGGCCGG GCTGATGAGG 60
CCGAGTTTGC CGACCAAGGG CACGGCGACG GTGGCGGCGA ACCAATAGCG CGTGATCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000195--Rab-GTPase-TBC_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50086--TBC_RABGAP
PS00678--WD_REPEATS_1
PS50294--WD_REPEATS_REGION

Pfam

PF00566--RabGAP-TBC

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome

KEGG

hsa:93594

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001553	Ailuropoda melanoleuca	87.91	0.00e+00	1905.00
IUUC-Apl-003213	Anas platyrhynchos	66.98	0.00e+00	1379.00
IUUC-Aca-004702	Anolis carolinensis	67.73	0.00e+00	1473.00
IUUC-Bta-012765	Bos taurus	85.66	0.00e+00	1812.00
IUUC-Cja-019040	Callithrix jacchus	95.31	0.00e+00	2063.00
IUUC-Cfa-020566	Canis familiaris	87.82	0.00e+00	1905.00
IUUC-Cpo-021286	Cavia porcellus	84.64	0.00e+00	1889.00
IUUC-Dre-028164	Danio rerio	56.16	0.00e+00	1183.00
IUUC-Eca-033820	Equus caballus	88.24	0.00e+00	1844.00
IUUC-Fca-036014	Felis catus	87.18	0.00e+00	1963.00
IUUC-Fal-037606	Ficedula albicollis	64.94	0.00e+00	1231.00
IUUC-Fox-038029	Fusarium oxysporum	27.75	6.00e-12	64.70
IUUC-Gmo-039702	Gadus morhua	58.50	0.00e+00	1031.00
IUUC-Gga-040127	Gallus gallus	67.31	0.00e+00	1352.00
IUUC-Gac-041774	Gasterosteus aculeatus	54.63	0.00e+00	1165.00
IUUC-Ggo-044807	Gorilla gorilla	73.79	0.00e+00	1469.00
IUUC-Itr-048341	Ictidomys tridecemlineatus	88.01	0.00e+00	1910.00
IUUC-Laf-053955	Loxodonta africana	90.47	0.00e+00	1655.00
IUUC-Mcc-055133	Macaca mulatta	97.00	0.00e+00	2026.00
IUUC-Mga-059365	Meleagris gallopavo	67.58	0.00e+00	1335.00
IUUC-Mmr-060967	Microcebus murinus	90.25	0.00e+00	1905.00
IUUC-Mdo-061940	Monodelphis domestica	66.70	0.00e+00	1454.00
IUUC-Mmu-063342	Mus musculus	87.39	0.00e+00	1578.00
IUUC-Mpu-066776	Mustela putorius furo	84.05	0.00e+00	1810.00
IUUC-Mlu-067051	Myotis lucifugus	87.35	0.00e+00	1882.00
IUUC-Nle-070170	Nomascus leucogenys	97.66	0.00e+00	2107.00
IUUC-Opr-071161	Ochotona princeps	81.12	0.00e+00	1745.00
IUUC-Oan-073226	Ornithorhynchus anatinus	84.59	3.00e-177	613.00
IUUC-Ocu-074283	Oryctolagus cuniculus	88.33	0.00e+00	1815.00
IUUC-Ola-087122	Oryzias latipes	59.96	0.00e+00	1193.00
IUUC-Oga-088451	Otolemur garnettii	87.99	0.00e+00	1916.00
IUUC-Oar-089779	Ovis aries	85.50	0.00e+00	1802.00
IUUC-Ptr-090826	Pan troglodytes	99.81	0.00e+00	2148.00
IUUC-Pan-092380	Papio anubis	97.00	0.00e+00	2021.00
IUUC-Psi-093491	Pelodiscus sinensis	68.73	0.00e+00	1494.00
IUUC-Pma-094672	Petromyzon marinus	56.16	4.00e-120	424.00
IUUC-Pab-098738	Pongo abelii	98.76	0.00e+00	1667.00
IUUC-Pva-102874	Pteropus vampyrus	82.98	0.00e+00	1239.00
IUUC-Rno-105316	Rattus norvegicus	81.24	0.00e+00	1781.00
IUUC-Sha-106804	Sarcophilus harrisii	66.95	0.00e+00	1484.00
IUUC-Sar-113482	Sorex araneus	76.30	0.00e+00	801.00
IUUC-Tgu-117092	Taeniopygia guttata	67.20	0.00e+00	1267.00
IUUC-Tru-117931	Takifugu rubripes	48.89	0.00e+00	1016.00
IUUC-Tni-120084	Tetraodon nigroviridis	60.66	0.00e+00	951.00
IUUC-Ttr-128747	Tursiops truncatus	84.28	0.00e+00	1749.00
IUUC-Xtr-131795	Xenopus tropicalis	62.71	0.00e+00	1339.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence