iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000156804.7	ENST00000517956.5	ENSP00000428205.1
ENSG00000156804.7	ENST00000443022.2	ENSP00000390790.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19117950; 15531760; 18354498; 19850579

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	95.49	0.00e+00	702.00	IUUC-Rno-105610

Organism

Homo sapiens

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

Protein Sequence
(Fasta)

MPFLGQDWRS PGQNWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYNKEN LFNSLNYDVA 60
AKKRKKDMLN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL GEAFNRLDFS TAILDSRRFN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACTCCCG GAGCCTGCAA CGCTTGAGAT CCTCTCCGCG CCCGCCACCC CGCAGGGTGC 60
CCCGCGCCGT TCCCGCCGCC CCGCCGCCCC CGTCGCGGGC CCCTGCACCC CGAGCATCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030018--C:Z disc
GO:0004842--F:ubiquitin-protein transferase activity
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0014894--P:response to denervation involved in regulation of muscle adaptation

KEGG

hsa:114907

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001986	Ailuropoda melanoleuca	98.87	0.00e+00	732.00
IUUC-Apl-003973	Anas platyrhynchos	92.16	2.00e-178	618.00
IUUC-Aca-004945	Anolis carolinensis	89.30	0.00e+00	656.00
IUUC-Ame-011383	Astyanax mexicanus	75.21	6.00e-164	570.00
IUUC-Bta-013522	Bos taurus	98.03	0.00e+00	727.00
IUUC-Bci-013735	Botrytis cinerea	32.08	1.60e-01	32.00
IUUC-Bdi-014435	Brachypodium distachyon	37.50	8.00e-05	40.80
IUUC-Bol-015763	Brassica oleracea	28.81	4.80e-02	31.60
IUUC-Cja-019893	Callithrix jacchus	99.44	0.00e+00	734.00
IUUC-Cfa-021053	Canis familiaris	98.31	0.00e+00	728.00
IUUC-Cpo-021330	Cavia porcellus	97.46	0.00e+00	723.00
IUUC-Csa-023160	Chlorocebus sabaeus	99.72	0.00e+00	736.00
IUUC-Cho-024993	Choloepus hoffmanni	77.56	2.00e-131	461.00
IUUC-Cin-025462	Ciona intestinalis	29.79	2.00e-25	109.00
IUUC-Csv-025908	Ciona savignyi	30.13	8.00e-42	164.00
IUUC-Cme-027326	Cyanidioschyzon merolae	24.80	6.00e-03	33.90
IUUC-Dre-028707	Danio rerio	75.63	9.00e-161	559.00
IUUC-Dno-029334	Dasypus novemcinctus	98.03	0.00e+00	728.00
IUUC-Dor-030350	Dipodomys ordii	97.65	0.00e+00	683.00
IUUC-Dme-031699	Drosophila melanogaster	28.49	4.00e-31	128.00
IUUC-Ete-033123	Echinops telfairi	76.66	3.00e-133	467.00
IUUC-Eca-033246	Equus caballus	98.87	0.00e+00	728.00
IUUC-Eeu-035339	Erinaceus europaeus	97.40	7.00e-133	466.00
IUUC-Fca-035805	Felis catus	98.86	0.00e+00	722.00
IUUC-Fal-037424	Ficedula albicollis	91.55	0.00e+00	690.00
IUUC-Gga-040478	Gallus gallus	92.68	0.00e+00	694.00
IUUC-Gac-042238	Gasterosteus aculeatus	72.85	1.00e-156	545.00
IUUC-Ggo-045515	Gorilla gorilla	99.72	0.00e+00	736.00
IUUC-Itr-048038	Ictidomys tridecemlineatus	98.59	0.00e+00	729.00
IUUC-Lch-049820	Latimeria chalumnae	81.13	9.00e-175	605.00
IUUC-Loc-051732	Lepisosteus oculatus	78.59	1.00e-169	588.00
IUUC-Laf-053789	Loxodonta africana	96.36	0.00e+00	686.00
IUUC-Mcc-055119	Macaca mulatta	99.72	0.00e+00	736.00
IUUC-Meu-056262	Macropus eugenii	80.18	1.00e-96	346.00
IUUC-Mga-059869	Meleagris gallopavo	85.11	1.00e-175	608.00
IUUC-Mmr-061443	Microcebus murinus	99.15	0.00e+00	733.00
IUUC-Mdo-062355	Monodelphis domestica	95.49	0.00e+00	714.00
IUUC-Mmu-064306	Mus musculus	96.62	0.00e+00	717.00
IUUC-Mpu-066902	Mustela putorius furo	98.47	0.00e+00	639.00
IUUC-Mlu-067076	Myotis lucifugus	97.46	0.00e+00	719.00
IUUC-Nle-069716	Nomascus leucogenys	99.72	0.00e+00	736.00
IUUC-Ont-072007	Oreochromis niloticus	73.74	2.00e-155	541.00
IUUC-Oan-073321	Ornithorhynchus anatinus	95.32	1.00e-160	558.00
IUUC-Ocu-074320	Oryctolagus cuniculus	97.18	0.00e+00	694.00
IUUC-Ola-087193	Oryzias latipes	73.74	9.00e-160	556.00
IUUC-Oga-088558	Otolemur garnettii	98.31	0.00e+00	730.00
IUUC-Oar-090092	Ovis aries	97.75	0.00e+00	725.00
IUUC-Ptr-091443	Pan troglodytes	99.15	0.00e+00	731.00
IUUC-Pan-092207	Papio anubis	99.72	0.00e+00	736.00
IUUC-Psi-093282	Pelodiscus sinensis	91.06	0.00e+00	683.00
IUUC-Pma-094448	Petromyzon marinus	66.48	3.00e-143	501.00
IUUC-Pfo-096873	Poecilia formosa	74.30	1.00e-160	559.00
IUUC-Pca-101124	Procavia capensis	96.34	0.00e+00	709.00
IUUC-Pva-102791	Pteropus vampyrus	98.03	0.00e+00	725.00
IUUC-Rno-105610	Rattus norvegicus	95.49	0.00e+00	702.00
IUUC-Sha-106684	Sarcophilus harrisii	96.06	0.00e+00	715.00
IUUC-Smo-109491	Selaginella moellendorffii	22.35	2.00e-03	37.00
IUUC-Sar-113077	Sorex araneus	88.61	2.00e-165	575.00
IUUC-Ssc-115993	Sus scrofa	95.77	0.00e+00	701.00
IUUC-Tgu-117376	Taeniopygia guttata	91.22	1.00e-177	615.00
IUUC-Tru-118690	Takifugu rubripes	73.18	5.00e-159	553.00
IUUC-Tni-120740	Tetraodon nigroviridis	71.79	2.00e-158	551.00
IUUC-Tbe-127713	Tupaia belangeri	89.24	2.00e-164	571.00
IUUC-Ttr-128339	Tursiops truncatus	99.15	0.00e+00	733.00
IUUC-Vpa-130070	Vicugna pacos	97.83	9.00e-81	293.00
IUUC-Xtr-132470	Xenopus tropicalis	83.94	0.00e+00	629.00
IUUC-Xma-133649	Xiphophorus maculatus	73.74	8.00e-161	559.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence