iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000157954.14	ENST00000288828.8	ENSP00000288828.4
ENSG00000157954.14	ENST00000401525.7	ENSP00000384945.3
ENSG00000157954.14	ENST00000404704.7	ENSP00000385297.3
ENSG00000157954.14	ENST00000382384.6	ENSP00000371821.2
ENSG00000157954.14	ENST00000484262.1	ENSP00000429654.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.10e-07	31.0	201	235

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgt.ikvWDlrtg 33
           H ++  +laf  s+t l+++s  gt i+v+++ +g
   Q: 201  HDSPLAALAFdaSGTKLATASEKGTvIRVFSIPEG 235
           9999999***9877***********9999987665 PP

Organism

Homo sapiens

Functional Description
(View)

Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.

Protein Sequence
(Fasta)

MNLASQSGEA GAGQLLFANF NQDNTEVKGA SRAAGLGRRA VVWSLAVGSK SGYKFFSLSS 60
VDKLEQIYEC TDTEDVCIVE RLFSSSLVAI VSLKAPRKLK VCHFKKGTEI CNYSYSNTIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCGCCGCTC GAGGCCGTGC GTCGCGGGGG CGGGGCCGCG CAGGCGTACC GGGTGCCCCG 60
GCTCTGGAGC ATAAACAAGA GCGGGGACGG GATGAGGCGG CGGTTGATCC CAGGGTGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR032911--WIPI2

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0043234--C:protein complex
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0010314--F:phosphatidylinositol-5-phosphate binding
GO:0000045--P:autophagosome assembly
GO:0016236--P:macroautophagy

KEGG

hsa:26100

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001842	Ailuropoda melanoleuca	95.13	0.00e+00	776.00
IUUC-Apl-003390	Anas platyrhynchos	92.77	0.00e+00	822.00
IUUC-Aca-004975	Anolis carolinensis	90.97	0.00e+00	847.00
IUUC-Ago-007768	Ashbya gossypii	27.61	4.00e-26	112.00
IUUC-Acl-008148	Aspergillus clavatus	43.92	3.00e-52	199.00
IUUC-Afl-008562	Aspergillus flavus	44.31	6.00e-53	201.00
IUUC-Afu-008936	Aspergillus fumigatus	34.87	3.00e-55	209.00
IUUC-Ani-009254	Aspergillus nidulans	44.31	4.00e-53	202.00
IUUC-Ang-009798	Aspergillus niger	35.29	4.00e-60	225.00
IUUC-Aor-010066	Aspergillus oryzae	44.31	6.00e-53	201.00
IUUC-Ate-010266	Aspergillus terreus	43.92	9.00e-53	201.00
IUUC-Ame-010727	Astyanax mexicanus	83.04	0.00e+00	776.00
IUUC-Bta-012655	Bos taurus	90.31	0.00e+00	818.00
IUUC-Bci-013627	Botrytis cinerea	34.20	1.00e-59	223.00
IUUC-Cel-018503	Caenorhabditis elegans	43.90	2.00e-81	296.00
IUUC-Cja-018829	Callithrix jacchus	96.48	0.00e+00	869.00
IUUC-Cfa-020858	Canis familiaris	92.58	0.00e+00	833.00
IUUC-Cpo-022235	Cavia porcellus	93.17	0.00e+00	835.00
IUUC-Csa-023963	Chlorocebus sabaeus	96.04	0.00e+00	837.00
IUUC-Cho-024328	Choloepus hoffmanni	75.06	0.00e+00	666.00
IUUC-Cin-025343	Ciona intestinalis	56.50	2.00e-135	475.00
IUUC-Csv-025920	Ciona savignyi	66.67	2.00e-147	514.00
IUUC-Cgl-026425	Colletotrichum gloeosporioides	46.45	2.00e-29	123.00
IUUC-Cne-026947	Cryptococcus neoformans	35.33	9.00e-59	220.00
IUUC-Dre-027490	Danio rerio	82.60	0.00e+00	772.00
IUUC-Dno-030057	Dasypus novemcinctus	88.35	0.00e+00	774.00
IUUC-Dor-030472	Dipodomys ordii	90.31	0.00e+00	814.00
IUUC-Dse-031215	Dothistroma septosporum	30.41	2.00e-49	190.00
IUUC-Ete-032362	Echinops telfairi	82.34	0.00e+00	759.00
IUUC-Eca-034362	Equus caballus	93.57	0.00e+00	810.00
IUUC-Fca-036230	Felis catus	93.68	0.00e+00	771.00
IUUC-Fal-036782	Ficedula albicollis	95.62	0.00e+00	821.00
IUUC-Fox-037797	Fusarium oxysporum	39.65	1.00e-49	191.00
IUUC-Fso-038174	Fusarium solani	40.35	7.00e-51	194.00
IUUC-Gmo-039706	Gadus morhua	55.46	2.00e-132	465.00
IUUC-Ggr-040113	Gaeumannomyces graminis	39.79	8.00e-50	191.00
IUUC-Gga-040690	Gallus gallus	91.19	0.00e+00	853.00
IUUC-Gac-041360	Gasterosteus aculeatus	83.04	0.00e+00	753.00
IUUC-Gma-043876	Glycine max	32.48	9.00e-36	144.00
IUUC-Itr-048693	Ictidomys tridecemlineatus	96.26	0.00e+00	878.00
IUUC-Kpa-049378	Komagataella pastoris	39.75	9.00e-52	197.00
IUUC-Lch-050413	Latimeria chalumnae	82.54	0.00e+00	723.00
IUUC-Lma-052948	Leptosphaeria maculans	32.75	3.00e-58	219.00
IUUC-Laf-054007	Loxodonta africana	90.71	0.00e+00	857.00
IUUC-Mor-057125	Magnaporthe oryzae	41.57	1.00e-48	187.00
IUUC-Mga-059795	Meleagris gallopavo	94.95	0.00e+00	822.00
IUUC-Mvi-060219	Microbotryum violaceum	37.54	1.00e-42	167.00
IUUC-Mmr-061096	Microcebus murinus	93.61	0.00e+00	863.00
IUUC-Mdo-061815	Monodelphis domestica	91.89	0.00e+00	860.00
IUUC-Mmu-063787	Mus musculus	91.36	0.00e+00	869.00
IUUC-Mpu-066019	Mustela putorius furo	89.44	0.00e+00	779.00
IUUC-Mlu-068016	Myotis lucifugus	90.97	0.00e+00	824.00
IUUC-Nfi-068424	Neosartorya fischeri	34.89	4.00e-56	212.00
IUUC-Ncr-068833	Neurospora crassa	33.41	9.00e-58	217.00
IUUC-Opr-070933	Ochotona princeps	79.74	0.00e+00	647.00
IUUC-Ont-072495	Oreochromis niloticus	82.07	0.00e+00	743.00
IUUC-Oan-073084	Ornithorhynchus anatinus	86.07	0.00e+00	769.00
IUUC-Ocu-074689	Oryctolagus cuniculus	92.41	0.00e+00	819.00
IUUC-Oga-088894	Otolemur garnettii	94.38	0.00e+00	797.00
IUUC-Oar-089850	Ovis aries	92.69	0.00e+00	816.00
IUUC-Ptr-090456	Pan troglodytes	97.36	0.00e+00	849.00
IUUC-Pan-092111	Papio anubis	93.09	0.00e+00	843.00
IUUC-Psi-094095	Pelodiscus sinensis	95.62	0.00e+00	820.00
IUUC-Pno-095015	Phaeosphaeria nodorum	32.80	8.00e-51	194.00
IUUC-Pfo-096987	Poecilia formosa	82.24	0.00e+00	740.00
IUUC-Pab-097754	Pongo abelii	99.30	0.00e+00	824.00
IUUC-Pva-103047	Pteropus vampyrus	83.92	0.00e+00	773.00
IUUC-Pte-104139	Pyrenophora teres	33.19	3.00e-53	202.00
IUUC-Pyt-104488	Pyrenophora triticirepentis	32.82	2.00e-53	203.00
IUUC-Rno-105990	Rattus norvegicus	91.79	0.00e+00	873.00
IUUC-Sha-106581	Sarcophilus harrisii	94.40	0.00e+00	812.00
IUUC-Sja-107913	Schizosaccharomyces japonicus	35.41	1.00e-49	190.00
IUUC-Spo-108068	Schizosaccharomyces pombe	37.95	1.00e-49	190.00
IUUC-Ssl-108418	Sclerotinia sclerotiorum	35.45	3.00e-64	239.00
IUUC-Sre-115219	Sporisorium reilianum	39.93	5.00e-46	178.00
IUUC-Ssc-116360	Sus scrofa	90.97	0.00e+00	802.00
IUUC-Tgu-116951	Taeniopygia guttata	93.56	0.00e+00	815.00
IUUC-Tru-117889	Takifugu rubripes	83.70	0.00e+00	766.00
IUUC-Tre-121895	Trichoderma reesei	39.30	4.00e-53	202.00
IUUC-Tvi-122311	Trichoderma virens	38.95	3.00e-53	202.00
IUUC-Uma-129438	Ustilago maydis	41.92	9.00e-41	161.00
IUUC-Vda-129782	Verticillium dahliae	46.28	7.00e-38	151.00
IUUC-Xma-133370	Xiphophorus maculatus	82.24	0.00e+00	740.00
IUUC-Yli-134337	Yarrowia lipolytica	37.02	2.00e-52	200.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence