iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045762

UUCD1 version

UUC-HoS-00283

Ensembl Protein ID

ENSP00000363390.3

UniProt Accession

Q969Q1; B4DN95; Q5T2I1; Q96BD3; Q96KD9; Q9BYV4; TRI63_HUMAN

Genbank Protein ID

CAC33173.1; AAK39519.1; CAC81706.1; AAK52497.1; BAB71318.1; BAG60157.1; CAI17133.1; AAH80529.1

Protein Name

E3 ubiquitin-protein ligase TRIM63; Iris RING finger protein; Muscle-specific RING finger protein 1; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; Striated muscle RING zinc finger protein; Tripartite motif-containing protein 63

Genbank Nucleotide ID

AJ291713; AF353673; AJ276484; AF361946; AK056942; AK297820; AL391650; BC080529

Gene Name

TRIM63; IRF; MURF1; RNF28; SMRZ

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000158022.6	ENST00000374272.3	ENSP00000363390.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19506036; 19498199; 19240029; 17786241; 19850579; 21356357; 18222470

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.60e-09	39.8	23	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...........pglknssskefrCPlCr 46
           C+iCle+f +++++lpC+H  +++C + +             + ++s ++frCP+Cr
   Q: 23   CPICLEMFTKPVVILPCQHNLCRKCANDIfqaanpywtsrGSSVSMSGGRFRCPTCR 79
           *************************755556667779**9888899**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Protein Sequence
(Fasta)

MDYKSSLIQD GNPMENLEKQ LICPICLEMF TKPVVILPCQ HNLCRKCAND IFQAANPYWT 60
SRGSSVSMSG GRFRCPTCRH EVIMDRHGVY GLQRNLLVEN IIDIYKQECS SRPLQKGSHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAGTGAAAT AAGTGGCCGA GGGATGGAGG ATGGGCTGGT TGGAGTGGGG GTCTCCATCA 60
TCTCCAGCAA AATGCTGTGC TGAAGTCTGA GGCAGAGGGA TGGGCTCAGA GAGAGGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0514--Muscle protein
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR017903--COS_domain
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51262--COS
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031430--C:M band
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0030018--C:Z disc
GO:0004871--F:signal transducer activity
GO:0031432--F:titin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006936--P:muscle contraction
GO:0010614--P:negative regulation of cardiac muscle hypertrophy
GO:0014878--P:response to electrical stimulus involved in regulation of muscle adaptation
GO:0051384--P:response to glucocorticoid
GO:0070555--P:response to interleukin-1
GO:0007165--P:signal transduction
GO:0014732--P:skeletal muscle atrophy

KEGG

hsa:84676

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001472	Ailuropoda melanoleuca	94.19	0.00e+00	643.00
IUUC-Apl-003286	Anas platyrhynchos	66.56	6.00e-130	457.00
IUUC-Aca-004871	Anolis carolinensis	73.70	1.00e-143	502.00
IUUC-Bta-013137	Bos taurus	92.99	0.00e+00	635.00
IUUC-Cja-019635	Callithrix jacchus	98.15	7.00e-180	622.00
IUUC-Cfa-020506	Canis familiaris	93.58	0.00e+00	639.00
IUUC-Cpo-022289	Cavia porcellus	94.77	0.00e+00	647.00
IUUC-Csa-023387	Chlorocebus sabaeus	97.84	2.00e-180	624.00
IUUC-Dno-029227	Dasypus novemcinctus	83.87	1.00e-172	598.00
IUUC-Dor-030999	Dipodomys ordii	81.60	9.00e-154	536.00
IUUC-Ete-033039	Echinops telfairi	92.31	1.00e-175	608.00
IUUC-Eca-033370	Equus caballus	93.79	9.00e-178	615.00
IUUC-Eeu-035345	Erinaceus europaeus	94.17	0.00e+00	643.00
IUUC-Fca-036216	Felis catus	94.15	0.00e+00	638.00
IUUC-Fal-036673	Ficedula albicollis	68.00	2.00e-124	439.00
IUUC-Gmo-038868	Gadus morhua	54.46	6.00e-104	370.00
IUUC-Gga-040807	Gallus gallus	76.09	2.00e-146	511.00
IUUC-Ggo-044440	Gorilla gorilla	99.39	0.00e+00	639.00
IUUC-Itr-048877	Ictidomys tridecemlineatus	92.59	0.00e+00	632.00
IUUC-Lch-049518	Latimeria chalumnae	68.52	1.00e-134	472.00
IUUC-Loc-052735	Lepisosteus oculatus	60.87	1.00e-129	456.00
IUUC-Laf-054300	Loxodonta africana	92.64	0.00e+00	634.00
IUUC-Mcc-055645	Macaca mulatta	98.17	0.00e+00	633.00
IUUC-Meu-056393	Macropus eugenii	73.15	6.00e-134	470.00
IUUC-Mga-059391	Meleagris gallopavo	75.78	3.00e-140	491.00
IUUC-Mmr-061101	Microcebus murinus	88.75	6.00e-169	586.00
IUUC-Mdo-062275	Monodelphis domestica	89.69	7.00e-175	606.00
IUUC-Mmu-063934	Mus musculus	93.48	0.00e+00	627.00
IUUC-Mpu-066782	Mustela putorius furo	94.50	0.00e+00	644.00
IUUC-Mlu-067263	Myotis lucifugus	93.46	2.00e-116	411.00
IUUC-Nle-070021	Nomascus leucogenys	95.72	9.00e-179	619.00
IUUC-Opr-070997	Ochotona princeps	93.25	0.00e+00	635.00
IUUC-Oan-072909	Ornithorhynchus anatinus	87.12	3.00e-171	594.00
IUUC-Ocu-073858	Oryctolagus cuniculus	92.64	0.00e+00	638.00
IUUC-Oga-088334	Otolemur garnettii	85.85	3.00e-163	567.00
IUUC-Oar-090426	Ovis aries	92.35	0.00e+00	634.00
IUUC-Ptr-091030	Pan troglodytes	99.69	0.00e+00	642.00
IUUC-Pan-091789	Papio anubis	98.16	0.00e+00	631.00
IUUC-Psi-093437	Pelodiscus sinensis	77.61	3.00e-156	544.00
IUUC-Pab-098375	Pongo abelii	98.77	0.00e+00	630.00
IUUC-Pva-103090	Pteropus vampyrus	91.44	2.00e-174	605.00
IUUC-Rno-105800	Rattus norvegicus	92.26	7.00e-180	622.00
IUUC-Sha-106977	Sarcophilus harrisii	90.12	2.00e-177	615.00
IUUC-Sar-113592	Sorex araneus	94.48	6.00e-178	616.00
IUUC-Ssc-116150	Sus scrofa	93.60	1.00e-175	608.00
IUUC-Tgu-117274	Taeniopygia guttata	76.23	8.00e-147	513.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence