iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063934

UUCD1 version

UUC-MuM-00018

Ensembl Protein ID

ENSMUSP00000101501.1

UniProt Accession

Q38HM4; Q8BWC4; TRI63_MOUSE

Genbank Protein ID

ABB16283.1; BAC35199.1

Protein Name

E3 ubiquitin-protein ligase TRIM63; Muscle-specific RING finger protein 1; RING-type E3 ubiquitin transferase TRIM63; Tripartite motif-containing protein 63

Genbank Nucleotide ID

DQ229108; AK052911

Gene Name

Trim63; Murf1; Rf1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000028834.13	ENSMUST00000030638.6	ENSMUSP00000030638.6
ENSMUSG00000028834.13	ENSMUST00000105875.7	ENSMUSP00000101501.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17983583

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.50e-10	40.1	23	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...........pglknssskefrCPlCr 46
           C+iCle+f +++++lpC+H  +++C + +            g+ ++s ++frCP Cr
   Q: 23   CPICLEMFTKPVVILPCQHNLCRKCANDIfqaanpywtnrGGSVSMSGGRFRCPSCR 79
           *************************755556667779***999999**********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Protein Sequence
(Fasta)

MDYKSSLIPD GNAMENLEKQ LICPICLEMF TKPVVILPCQ HNLCRKCAND IFQAANPYWT 60
NRGGSVSMSG GRFRCPSCRH EVIMDRHGVY GLQRNLLVEN IIDIYKQECS SRPLQKGSHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAGTCGGG GGTCAGGGGA CGAAGACAAA GAGGATCCGA GTGGGTTTGG AGACAAAGAC 60
TTGGTGTGAC GCAGGTGGGC GAGACAGTCG CATTTCAAAG CAATATGGAT TATAAATCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0514--Muscle protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR017903--COS_domain
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51262--COS
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0043292--C:contractile fiber
GO:0005737--C:cytoplasm
GO:0031430--C:M band
GO:0005634--C:nucleus
GO:0030018--C:Z disc
GO:0031432--F:titin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0006936--P:muscle contraction
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010468--P:regulation of gene expression
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0014878--P:response to electrical stimulus involved in regulation of muscle adaptation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001472	Ailuropoda melanoleuca	95.05	0.00e+00	639.00
IUUC-Apl-003286	Anas platyrhynchos	66.56	3.00e-127	448.00
IUUC-Aca-004871	Anolis carolinensis	74.92	3.00e-145	507.00
IUUC-Bta-013137	Bos taurus	92.90	0.00e+00	626.00
IUUC-Cja-019635	Callithrix jacchus	93.19	5.00e-172	596.00
IUUC-Cfa-020506	Canis familiaris	93.19	0.00e+00	629.00
IUUC-Cpo-022289	Cavia porcellus	94.43	0.00e+00	636.00
IUUC-Csa-023387	Chlorocebus sabaeus	93.19	2.00e-172	598.00
IUUC-Dno-029227	Dasypus novemcinctus	82.61	3.00e-167	581.00
IUUC-Dor-030999	Dipodomys ordii	83.59	5.00e-156	543.00
IUUC-Ete-033039	Echinops telfairi	94.12	9.00e-177	612.00
IUUC-Eca-033370	Equus caballus	94.10	1.00e-177	615.00
IUUC-Eeu-035345	Erinaceus europaeus	94.43	0.00e+00	638.00
IUUC-Fca-036216	Felis catus	93.81	0.00e+00	632.00
IUUC-Fal-036673	Ficedula albicollis	66.87	8.00e-122	429.00
IUUC-Gga-040807	Gallus gallus	75.16	1.00e-144	506.00
IUUC-Ggo-044440	Gorilla gorilla	93.81	3.00e-172	597.00
IUUC-Hsa-045762	Homo sapiens	93.50	1.00e-172	598.00
IUUC-Itr-048877	Ictidomys tridecemlineatus	92.88	0.00e+00	632.00
IUUC-Lch-049518	Latimeria chalumnae	68.73	2.00e-135	474.00
IUUC-Loc-052735	Lepisosteus oculatus	58.31	5.00e-124	437.00
IUUC-Laf-054300	Loxodonta africana	92.88	1.00e-180	625.00
IUUC-Mcc-055645	Macaca mulatta	93.50	3.00e-173	600.00
IUUC-Meu-056393	Macropus eugenii	74.30	9.00e-135	473.00
IUUC-Mga-059391	Meleagris gallopavo	75.47	8.00e-140	489.00
IUUC-Mmr-061101	Microcebus murinus	90.13	7.00e-169	586.00
IUUC-Mdo-062275	Monodelphis domestica	90.00	2.00e-175	608.00
IUUC-Mpu-066782	Mustela putorius furo	94.12	0.00e+00	633.00
IUUC-Mlu-067263	Myotis lucifugus	92.96	8.00e-115	405.00
IUUC-Nle-070021	Nomascus leucogenys	91.95	2.00e-170	591.00
IUUC-Opr-070997	Ochotona princeps	93.81	0.00e+00	634.00
IUUC-Oan-072909	Ornithorhynchus anatinus	87.62	7.00e-171	593.00
IUUC-Ocu-073858	Oryctolagus cuniculus	93.50	0.00e+00	637.00
IUUC-Oga-088334	Otolemur garnettii	85.45	1.00e-161	562.00
IUUC-Oar-090426	Ovis aries	93.19	0.00e+00	632.00
IUUC-Ptr-091030	Pan troglodytes	93.81	4.00e-173	600.00
IUUC-Pan-091789	Papio anubis	93.50	3.00e-173	600.00
IUUC-Psi-093437	Pelodiscus sinensis	77.40	4.00e-153	534.00
IUUC-Pab-098375	Pongo abelii	93.81	4.00e-173	600.00
IUUC-Pva-103090	Pteropus vampyrus	90.71	5.00e-170	590.00
IUUC-Rno-105800	Rattus norvegicus	97.83	0.00e+00	654.00
IUUC-Sha-106977	Sarcophilus harrisii	90.71	9.00e-178	615.00
IUUC-Sar-113592	Sorex araneus	95.36	1.00e-176	612.00
IUUC-Ssc-116150	Sus scrofa	92.59	5.00e-171	593.00
IUUC-Tgu-117274	Taeniopygia guttata	75.54	5.00e-145	507.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence