iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000158023.9	ENST00000288912.8	ENSP00000288912.4
ENSG00000158023.9	ENST00000397454.2	ENSP00000380595.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.50e-06	27.8	452	477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 5    svtclafsdtllvsGsdDgtikvWDlrt 32
           s++ l++  t ++s++  g++ vWD+++
   Q: 452  SIFHLNL--TQILSATMEGKLVVWDIHR 477
           6777777..99**************876 PP

Organism

Homo sapiens

Functional Description
(View)

May regulate cilium motility through its role in the assembly of the axonemal radial spokes.

Protein Sequence
(Fasta)

MSDAAEAPRE ATGENGETEM KEEEEPNPNY KEVEDPQQES KDDTIAWRES QEEERKTGEE 60
EGEEEGKEDK KIVMEETEEK AGEVQEKEAS GIQEETTVEP QEVTASMIRL ETQITDSQSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTATCCTTT CTTTTTTATT TTAAGATGTA TGCATATTAA TCAATTTACC ATCACTGGGG 60
CATGGCAGTG TGGGCGGGGA GAATTATTCA CATTCTCCTA AAATGACAGC AGCAGAGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011992--EF-hand-dom_pair
IPR027295--Quinoprotein_ADH-like_fam
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005930--C:axoneme

KEGG

hsa:144406

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002305	Ailuropoda melanoleuca	81.74	0.00e+00	1790.00
IUUC-Apl-003833	Anas platyrhynchos	56.28	0.00e+00	1011.00
IUUC-Ame-011318	Astyanax mexicanus	48.17	0.00e+00	874.00
IUUC-Bta-013319	Bos taurus	79.79	0.00e+00	1719.00
IUUC-Cja-019874	Callithrix jacchus	89.56	0.00e+00	2084.00
IUUC-Cfa-021224	Canis familiaris	79.67	0.00e+00	1836.00
IUUC-Cpo-022038	Cavia porcellus	70.99	0.00e+00	1395.00
IUUC-Cre-022950	Chlamydomonas reinhardtii	27.82	6.00e-62	232.00
IUUC-Csa-024266	Chlorocebus sabaeus	85.78	0.00e+00	1855.00
IUUC-Cin-025361	Ciona intestinalis	43.51	0.00e+00	820.00
IUUC-Csv-026051	Ciona savignyi	43.83	0.00e+00	809.00
IUUC-Dre-028130	Danio rerio	44.33	0.00e+00	872.00
IUUC-Dno-029069	Dasypus novemcinctus	79.64	0.00e+00	1212.00
IUUC-Ete-032698	Echinops telfairi	77.43	0.00e+00	799.00
IUUC-Eca-033728	Equus caballus	79.70	0.00e+00	1809.00
IUUC-Eeu-034707	Erinaceus europaeus	83.21	4.00e-143	502.00
IUUC-Fca-035974	Felis catus	81.62	0.00e+00	1761.00
IUUC-Fal-037073	Ficedula albicollis	52.44	0.00e+00	998.00
IUUC-Gmo-039607	Gadus morhua	47.19	2.00e-144	506.00
IUUC-Gga-040440	Gallus gallus	53.80	0.00e+00	999.00
IUUC-Gac-042234	Gasterosteus aculeatus	44.01	0.00e+00	772.00
IUUC-Ggo-044473	Gorilla gorilla	99.65	0.00e+00	1196.00
IUUC-Itr-049034	Ictidomys tridecemlineatus	75.02	0.00e+00	1655.00
IUUC-Lch-049489	Latimeria chalumnae	50.05	0.00e+00	920.00
IUUC-Loc-052793	Lepisosteus oculatus	52.45	0.00e+00	1021.00
IUUC-Laf-054246	Loxodonta africana	86.71	0.00e+00	807.00
IUUC-Mcc-054827	Macaca mulatta	92.78	0.00e+00	2104.00
IUUC-Meu-056344	Macropus eugenii	64.34	0.00e+00	924.00
IUUC-Mga-059830	Meleagris gallopavo	54.07	0.00e+00	994.00
IUUC-Mmr-061157	Microcebus murinus	82.93	0.00e+00	1777.00
IUUC-Mdo-062870	Monodelphis domestica	68.80	0.00e+00	1362.00
IUUC-Mmu-064101	Mus musculus	78.84	0.00e+00	1593.00
IUUC-Mpu-066432	Mustela putorius furo	84.48	0.00e+00	1701.00
IUUC-Mlu-068011	Myotis lucifugus	71.46	0.00e+00	1519.00
IUUC-Nle-069572	Nomascus leucogenys	90.85	0.00e+00	1998.00
IUUC-Opr-070235	Ochotona princeps	83.78	0.00e+00	1548.00
IUUC-Oan-073735	Ornithorhynchus anatinus	67.10	0.00e+00	1316.00
IUUC-Ocu-074669	Oryctolagus cuniculus	78.42	0.00e+00	1617.00
IUUC-Oga-089007	Otolemur garnettii	84.71	0.00e+00	1809.00
IUUC-Ptr-091286	Pan troglodytes	98.87	0.00e+00	2259.00
IUUC-Pan-091905	Papio anubis	93.57	0.00e+00	2104.00
IUUC-Psi-093555	Pelodiscus sinensis	54.52	0.00e+00	1082.00
IUUC-Pma-094736	Petromyzon marinus	35.98	0.00e+00	646.00
IUUC-Pfo-097081	Poecilia formosa	42.66	0.00e+00	754.00
IUUC-Pab-097893	Pongo abelii	95.86	0.00e+00	2173.00
IUUC-Rno-105786	Rattus norvegicus	79.87	0.00e+00	1573.00
IUUC-Sha-107399	Sarcophilus harrisii	67.60	0.00e+00	1340.00
IUUC-Tgu-116796	Taeniopygia guttata	54.68	0.00e+00	1025.00
IUUC-Tru-118592	Takifugu rubripes	41.52	0.00e+00	714.00
IUUC-Tni-120456	Tetraodon nigroviridis	40.07	0.00e+00	679.00
IUUC-Tbe-127411	Tupaia belangeri	81.02	2.00e-106	380.00
IUUC-Xtr-131990	Xenopus tropicalis	52.18	0.00e+00	1022.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence