iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000014917.7	ENSRNOT00000020330.7	ENSRNOP00000020330.6
ENSRNOG00000014917.7	ENSRNOT00000091593.1	ENSRNOP00000069028.1

Annotation

mRNA Expression
ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.00e-38	131.5	189	248

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly+++++nd+eL+++kGdv++viek e+d +W+k+ ++ +g  Gl+P+n+v+ ++
   Q: 189  LHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKC-RKINGMVGLVPKNYVTVMQ 248
           689**************************************.59*************9765 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAEEVVVVAK FDYVAQQEQE LDIKEERLWL MDDSKSWCEV RNSMNKTGFV SNYVKGKNSA 60
RKASIVKPKD TLGIGKVKRK PSVPDTASPA DDSFVDPGER LYDLNMPAFV KFNYMAERED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGAGCTA CGCGGCGGCG CAGCACAGGC CTCGTGCGGT AACGGCATCC GGCCAGCCGC 60
GGTGGCGTCC CGGTGCAGTC CTCAGGTGAC TGGAGCCGCG GGCTCGGCGG AGGGAAGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	95.49	0.00e+00	699.00
IUUC-Ame-011235	Astyanax mexicanus	75.99	8.00e-170	589.00
IUUC-Bta-013039	Bos taurus	95.49	0.00e+00	700.00
IUUC-Cja-019546	Callithrix jacchus	95.76	0.00e+00	694.00
IUUC-Cfa-020462	Canis familiaris	95.76	0.00e+00	702.00
IUUC-Cpo-022009	Cavia porcellus	95.49	0.00e+00	696.00
IUUC-Csa-023875	Chlorocebus sabaeus	96.55	0.00e+00	702.00
IUUC-Cho-024368	Choloepus hoffmanni	95.32	0.00e+00	640.00
IUUC-Dre-028407	Danio rerio	74.93	3.00e-167	581.00
IUUC-Dno-029593	Dasypus novemcinctus	94.89	1.00e-163	568.00
IUUC-Dor-030730	Dipodomys ordii	95.53	1.00e-175	608.00
IUUC-Ete-032906	Echinops telfairi	94.69	0.00e+00	689.00
IUUC-Eca-033378	Equus caballus	96.35	4.00e-178	616.00
IUUC-Eeu-034743	Erinaceus europaeus	85.41	0.00e+00	638.00
IUUC-Fca-035745	Felis catus	95.49	0.00e+00	740.00
IUUC-Gac-042245	Gasterosteus aculeatus	73.52	3.00e-148	517.00
IUUC-Ggo-045487	Gorilla gorilla	96.55	0.00e+00	703.00
IUUC-Hsa-045902	Homo sapiens	96.55	0.00e+00	702.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	96.29	0.00e+00	702.00
IUUC-Lch-050165	Latimeria chalumnae	80.11	8.00e-170	589.00
IUUC-Loc-052523	Lepisosteus oculatus	76.12	3.00e-168	584.00
IUUC-Laf-053845	Loxodonta africana	95.49	0.00e+00	698.00
IUUC-Meu-056139	Macropus eugenii	88.59	0.00e+00	630.00
IUUC-Mmr-061108	Microcebus murinus	84.35	6.00e-163	566.00
IUUC-Mdo-062258	Monodelphis domestica	91.51	0.00e+00	674.00
IUUC-Mmu-063970	Mus musculus	97.08	0.00e+00	746.00
IUUC-Mpu-066093	Mustela putorius furo	95.23	0.00e+00	698.00
IUUC-Mlu-067193	Myotis lucifugus	95.49	0.00e+00	699.00
IUUC-Nle-069611	Nomascus leucogenys	96.55	0.00e+00	702.00
IUUC-Opr-070984	Ochotona princeps	97.34	5.00e-179	619.00
IUUC-Ont-072241	Oreochromis niloticus	73.33	1.00e-160	559.00
IUUC-Oan-072976	Ornithorhynchus anatinus	89.22	5.00e-166	576.00
IUUC-Ocu-073905	Oryctolagus cuniculus	96.55	0.00e+00	703.00
IUUC-Ola-086513	Oryzias latipes	72.05	1.00e-147	515.00
IUUC-Oga-088588	Otolemur garnettii	96.02	0.00e+00	701.00
IUUC-Oar-089973	Ovis aries	95.76	0.00e+00	702.00
IUUC-Ptr-090968	Pan troglodytes	96.55	0.00e+00	702.00
IUUC-Pan-092840	Papio anubis	95.85	2.00e-164	571.00
IUUC-Pfo-096057	Poecilia formosa	72.19	1.00e-158	552.00
IUUC-Pab-097807	Pongo abelii	96.29	0.00e+00	702.00
IUUC-Pca-100522	Procavia capensis	94.25	3.00e-162	564.00
IUUC-Pva-103083	Pteropus vampyrus	95.76	0.00e+00	701.00
IUUC-Sha-107294	Sarcophilus harrisii	90.98	0.00e+00	669.00
IUUC-Sar-113675	Sorex araneus	93.90	0.00e+00	685.00
IUUC-Ssc-116442	Sus scrofa	94.69	0.00e+00	733.00
IUUC-Tru-118058	Takifugu rubripes	72.01	2.00e-157	548.00
IUUC-Tsy-119184	Tarsius syrichta	89.14	3.00e-175	607.00
IUUC-Tni-119974	Tetraodon nigroviridis	72.45	2.00e-146	511.00
IUUC-Ttr-129155	Tursiops truncatus	93.37	0.00e+00	694.00
IUUC-Vpa-130344	Vicugna pacos	95.49	0.00e+00	701.00
IUUC-Xtr-132372	Xenopus tropicalis	84.04	7.00e-179	619.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence