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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046861
Ensembl Protein ID ENSP00000320130.6
UniProt Accession O14576; B4DME3; F5H050; G5E9K1; Q8TBF7; Q9Y2X1; DC1I1_HUMAN
Genbank Protein ID AAC33443.1; AAD26852.1; BAC03639.1; BAG59855.1; AAB67047.2; AAB70113.1; EAW76753.1; AAH22540.1
Protein Name Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein intermediate chain 1; Dynein intermediate chain 1, cytosolic
Genbank Nucleotide ID AF063228; AF123074; AK091339; AK297427; AC022261; AC002540; CH471091; BC022540
Gene Name DYNC1I1; DNCI1; DNCIC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000158560.14 ENST00000447467.6 ENSP00000392337.2
ENSG00000158560.14 ENST00000324972.10 ENSP00000320130.6
ENSG00000158560.14 ENST00000630942.2 ENSP00000486363.1
ENSG00000158560.14 ENST00000437599.5 ENSP00000398118.1
ENSG00000158560.14 ENST00000359388.8 ENSP00000352348.4
ENSG00000158560.14 ENST00000413338.5 ENSP00000411957.1
ENSG00000158560.14 ENST00000518089.5 ENSP00000428273.1
ENSG00000158560.14 ENST00000537881.5 ENSP00000438377.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-12 49.3 340 374
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 3    tdsvtclaf....sdtllvsGsdDgtikvWDlrtgv 34
           ++sv +++f    + +l+v G++ g+i +WD r+++
   Q: 340  QSSVMSVCFarfhP-NLVVGGTYSGQIVLWDNRSHR 374
           57899999999754.9999999*********98875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity).
 Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity).
Protein Sequence
(Fasta)
MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 60
ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS KSVSTPSEAG SQDSGDLGPL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046861|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGGGCGCGG GCGTGGAGGG CGTGGGCAGG GGGCGGGGCG AGCCCCGCAG ACTGAGTGCT 60
CCGGGGAGCT GTCAGTGTCA GGCTCTGGGA GAGAGGAAGT GATCGCTCCC GGAGGAGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046861|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0243--Dynein
KW-0995--Kinetochore
KW-0493--Microtubule
KW-0505--Motor protein
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR025956--DYNC1I1/DYNC1I2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50294--WD_REPEATS_REGION
Pfam

PF11540--Dynein_IC2
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005737--C:cytoplasm
GO:0005868--C:cytoplasmic dynein complex
GO:0036464--C:cytoplasmic ribonucleoprotein granule
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0000922--C:spindle pole
GO:0031982--C:vesicle
GO:0008017--F:microtubule binding
GO:0003777--F:microtubule motor activity
GO:0003774--F:motor activity
GO:0030507--F:spectrin binding
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0047496--P:vesicle transport along microtubule
KEGG hsa:1780
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001500 Ailuropoda melanoleuca 98.91 0.00e+00 1243.00
IUUC-Aca-004659 Anolis carolinensis 92.87 0.00e+00 1136.00
IUUC-Ame-010879 Astyanax mexicanus 81.02 0.00e+00 1032.00
IUUC-Bgr-011987 Blumeria graminis 39.91 3.00e-100 359.00
IUUC-Bta-013557 Bos taurus 92.40 0.00e+00 1134.00
IUUC-Cja-018913 Callithrix jacchus 99.53 0.00e+00 1250.00
IUUC-Cfa-020794 Canis familiaris 96.43 0.00e+00 1197.00
IUUC-Cpo-021891 Cavia porcellus 98.65 0.00e+00 980.00
IUUC-Csa-023506 Chlorocebus sabaeus 96.90 0.00e+00 1199.00
IUUC-Cho-025102 Choloepus hoffmanni 84.96 0.00e+00 1020.00
IUUC-Csv-025876 Ciona savignyi 47.48 3.00e-175 608.00
IUUC-Cgl-026617 Colletotrichum gloeosporioides 39.96 7.00e-88 318.00
IUUC-Dre-028093 Danio rerio 76.74 0.00e+00 957.00
IUUC-Dno-029846 Dasypus novemcinctus 98.47 0.00e+00 952.00
IUUC-Dor-030613 Dipodomys ordii 98.91 0.00e+00 1240.00
IUUC-Ete-032322 Echinops telfairi 83.72 0.00e+00 1011.00
IUUC-Eca-033324 Equus caballus 99.22 0.00e+00 1247.00
IUUC-Fca-036050 Felis catus 92.92 0.00e+00 1104.00
IUUC-Fal-037664 Ficedula albicollis 93.95 0.00e+00 1174.00
IUUC-Gmo-038624 Gadus morhua 72.87 0.00e+00 862.00
IUUC-Gga-040886 Gallus gallus 93.33 0.00e+00 1168.00
IUUC-Gac-042215 Gasterosteus aculeatus 75.50 0.00e+00 901.00
IUUC-Ggo-045363 Gorilla gorilla 100.00 0.00e+00 1255.00
IUUC-Itr-048603 Ictidomys tridecemlineatus 98.48 0.00e+00 952.00
IUUC-Kpa-049295 Komagataella pastoris 24.89 4.00e-29 123.00
IUUC-Loc-052873 Lepisosteus oculatus 86.71 0.00e+00 1082.00
IUUC-Laf-053494 Loxodonta africana 98.29 0.00e+00 1239.00
IUUC-Mcc-055731 Macaca mulatta 99.69 0.00e+00 1250.00
IUUC-Mor-056924 Magnaporthe oryzae 42.63 4.00e-100 359.00
IUUC-Mpo-057521 Magnaporthe poae 38.38 7.00e-82 298.00
IUUC-Mga-059796 Meleagris gallopavo 93.98 0.00e+00 957.00
IUUC-Mmr-060828 Microcebus murinus 99.07 0.00e+00 1246.00
IUUC-Mmu-063862 Mus musculus 98.14 0.00e+00 1237.00
IUUC-Mpu-066835 Mustela putorius furo 96.12 0.00e+00 1194.00
IUUC-Mlu-067993 Myotis lucifugus 97.69 0.00e+00 1230.00
IUUC-Nfi-068441 Neosartorya fischeri 40.35 1.00e-89 324.00
IUUC-Nle-069711 Nomascus leucogenys 99.84 0.00e+00 1253.00
IUUC-Opr-070509 Ochotona princeps 97.54 0.00e+00 1183.00
IUUC-Ont-072346 Oreochromis niloticus 78.27 0.00e+00 957.00
IUUC-Ocu-074398 Oryctolagus cuniculus 95.35 0.00e+00 1185.00
IUUC-Ola-087168 Oryzias latipes 75.50 0.00e+00 934.00
IUUC-Oga-088138 Otolemur garnettii 97.40 0.00e+00 932.00
IUUC-Oar-090454 Ovis aries 95.19 0.00e+00 1183.00
IUUC-Ptr-090850 Pan troglodytes 100.00 0.00e+00 1255.00
IUUC-Pan-092449 Papio anubis 96.90 0.00e+00 1199.00
IUUC-Psi-093490 Pelodiscus sinensis 93.49 0.00e+00 1152.00
IUUC-Pab-098252 Pongo abelii 99.69 0.00e+00 1250.00
IUUC-Pca-100827 Procavia capensis 97.70 0.00e+00 641.00
IUUC-Pva-102223 Pteropus vampyrus 93.80 0.00e+00 1157.00
IUUC-Ptt-103792 Puccinia triticina 40.99 2.00e-109 389.00
IUUC-Rno-105683 Rattus norvegicus 97.98 0.00e+00 1226.00
IUUC-Sja-107798 Schizosaccharomyces japonicus 25.11 6.00e-30 125.00
IUUC-Ssc-115238 Sus scrofa 98.89 0.00e+00 1098.00
IUUC-Tgu-117310 Taeniopygia guttata 90.25 0.00e+00 974.00
IUUC-Tsy-119423 Tarsius syrichta 84.19 0.00e+00 971.00
IUUC-Ttr-129188 Tursiops truncatus 99.22 0.00e+00 1247.00
IUUC-Vda-129769 Verticillium dahliae 35.91 7.00e-25 107.00
IUUC-Xtr-132370 Xenopus tropicalis 88.66 0.00e+00 966.00
Created Date 25-Jun-2017

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