iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000006498.3	ENSMMUT00000009115.3	ENSMMUP00000008564.3
ENSMMUG00000006498.3	ENSMMUT00000009117.3	ENSMMUP00000008566.3
ENSMMUG00000006498.3	ENSMMUT00000062614.1	ENSMMUP00000046055.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	2.90e-40	137.4	226	302
E3 activity/RING/RING	3.70e-08	34.8	1098	1201
E3 activity/N-recognin/UBR-box	3.50e-31	108.6	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG+ya+c+eak++i+++se+++q+pL+Vev
   Q: 226  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEV 302
           9**************************************************************************97 PP

E3 activity/RING/RING

   S: 1    CaiCledf...............kd..............................gplvlpCgHvfhadClqkw............. 29
           C++C+e+                ++                              g+++++CgHv+ha C+qk+             
   Q: 1098 CILCQEEQevkiennamvlsacvQKstaltqhrgkpielsgetldplfmdpdlayGTYTGSCGHVMHAVCWQKYfeavqlssqqrih 1184
           78885544433333333333222002233333333333333333333333333337999**************************** PP
   S: 30   pglknssskefrCPlCr 46
           ++l +++s+e +CPlC+
   Q: 1185 VDLFDLESGEYLCPLCK 1201
           ****************7 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C++++
   Q: 97   QLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHE 167
           68*******************************************************************96 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MADEEAGGAE RMEISAELPQ TPQRLACWWD QQVDFYTAFL HHLAQLVPEI YFAEMDPDLE 60
KQEQSVQMSI FTPLEWYLFG EDPDICLEKL KHSGAFQLCG KVFKSGETTY SCRDCAIDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTATGTTGCC CATCTCAAAC AATCCTCCCG CCTTGGCCTC CCAAAGTGCT AACATTACAG 60
GGGTGAGCCA TTGTGCTGGC TGAATGTCTG CTCTGTCACT TGGAAGCTGC ATGTCCCTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:709238

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001354	Ailuropoda melanoleuca	95.04	0.00e+00	3347.00
IUUC-Apl-004160	Anas platyrhynchos	78.22	0.00e+00	2749.00
IUUC-Aca-004982	Anolis carolinensis	75.43	0.00e+00	2655.00
IUUC-Acl-008055	Aspergillus clavatus	23.20	1.00e-47	186.00
IUUC-Ate-010550	Aspergillus terreus	23.31	3.00e-47	185.00
IUUC-Ame-011231	Astyanax mexicanus	57.47	0.00e+00	1894.00
IUUC-Bgr-011999	Blumeria graminis	23.24	6.00e-46	181.00
IUUC-Bta-012347	Bos taurus	93.92	0.00e+00	3308.00
IUUC-Bci-013834	Botrytis cinerea	22.76	1.00e-40	163.00
IUUC-Cja-018911	Callithrix jacchus	92.98	0.00e+00	3235.00
IUUC-Cfa-020991	Canis familiaris	95.72	0.00e+00	3375.00
IUUC-Cpo-021448	Cavia porcellus	92.02	0.00e+00	3241.00
IUUC-Csa-024255	Chlorocebus sabaeus	99.73	0.00e+00	2880.00
IUUC-Cho-024550	Choloepus hoffmanni	73.60	0.00e+00	2485.00
IUUC-Dno-029427	Dasypus novemcinctus	93.29	0.00e+00	3193.00
IUUC-Dor-031073	Dipodomys ordii	79.35	0.00e+00	1380.00
IUUC-Ete-032318	Echinops telfairi	75.86	0.00e+00	1268.00
IUUC-Eca-033348	Equus caballus	94.63	0.00e+00	3088.00
IUUC-Eeu-034664	Erinaceus europaeus	85.26	0.00e+00	2984.00
IUUC-Fca-035604	Felis catus	89.22	0.00e+00	3051.00
IUUC-Fal-037333	Ficedula albicollis	78.23	0.00e+00	2709.00
IUUC-Fox-037984	Fusarium oxysporum	26.94	5.00e-40	160.00
IUUC-Gmo-039363	Gadus morhua	56.11	0.00e+00	1655.00
IUUC-Gga-040486	Gallus gallus	77.17	0.00e+00	2660.00
IUUC-Gac-041985	Gasterosteus aculeatus	56.70	0.00e+00	1731.00
IUUC-Ggo-044704	Gorilla gorilla	90.93	0.00e+00	2660.00
IUUC-Hsa-046753	Homo sapiens	98.34	0.00e+00	3456.00
IUUC-Itr-048410	Ictidomys tridecemlineatus	95.16	0.00e+00	3336.00
IUUC-Lch-049904	Latimeria chalumnae	61.92	0.00e+00	2124.00
IUUC-Loc-052624	Lepisosteus oculatus	60.90	0.00e+00	2053.00
IUUC-Laf-053857	Loxodonta africana	91.82	0.00e+00	3207.00
IUUC-Meu-056858	Macropus eugenii	66.50	0.00e+00	1031.00
IUUC-Mga-059917	Meleagris gallopavo	77.26	0.00e+00	2769.00
IUUC-Mmr-061128	Microcebus murinus	92.58	0.00e+00	3199.00
IUUC-Mdo-062306	Monodelphis domestica	80.78	0.00e+00	2828.00
IUUC-Mmu-063389	Mus musculus	92.26	0.00e+00	3270.00
IUUC-Mpu-065983	Mustela putorius furo	95.38	0.00e+00	3387.00
IUUC-Mlu-068013	Myotis lucifugus	91.79	0.00e+00	3243.00
IUUC-Nle-070031	Nomascus leucogenys	98.57	0.00e+00	3465.00
IUUC-Opr-070551	Ochotona princeps	71.08	0.00e+00	1379.00
IUUC-Ont-072035	Oreochromis niloticus	57.78	0.00e+00	1967.00
IUUC-Ocu-074930	Oryctolagus cuniculus	90.54	0.00e+00	3170.00
IUUC-Oba-075295	Oryza barthii	38.54	6.00e-14	74.30
IUUC-Ogu-078497	Oryza glumaepatula	38.54	5.00e-14	74.70
IUUC-Oin-079343	Oryza indica	38.54	7.00e-14	74.30
IUUC-Oni-083099	Oryza nivara	38.54	6.00e-14	74.30
IUUC-Oru-084471	Oryza rufipogon	38.54	6.00e-14	74.30
IUUC-Osa-086106	Oryza sativa	37.59	1.00e-13	72.00
IUUC-Ola-086683	Oryzias latipes	57.48	0.00e+00	1917.00
IUUC-Oga-088017	Otolemur garnettii	90.23	0.00e+00	3155.00
IUUC-Oar-089557	Ovis aries	93.43	0.00e+00	3303.00
IUUC-Ptr-091366	Pan troglodytes	97.14	0.00e+00	3436.00
IUUC-Pan-092184	Papio anubis	99.77	0.00e+00	3445.00
IUUC-Psi-093720	Pelodiscus sinensis	79.23	0.00e+00	2716.00
IUUC-Ppa-095780	Physcomitrella patens	21.74	9.00e-25	110.00
IUUC-Pfo-097124	Poecilia formosa	57.15	0.00e+00	1932.00
IUUC-Pab-098586	Pongo abelii	98.63	0.00e+00	3461.00
IUUC-Pop-099184	Populus trichocarpa	44.21	1.00e-13	70.90
IUUC-Pca-100673	Procavia capensis	85.17	0.00e+00	1739.00
IUUC-Pva-102724	Pteropus vampyrus	88.71	0.00e+00	3088.00
IUUC-Pte-104174	Pyrenophora teres	23.19	1.00e-48	189.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	22.98	2.00e-47	186.00
IUUC-Rno-105474	Rattus norvegicus	88.65	0.00e+00	2336.00
IUUC-Sha-106993	Sarcophilus harrisii	81.26	0.00e+00	2912.00
IUUC-Sar-113447	Sorex araneus	88.22	0.00e+00	2166.00
IUUC-Ssc-115768	Sus scrofa	90.47	0.00e+00	2960.00
IUUC-Tgu-116949	Taeniopygia guttata	73.34	0.00e+00	2492.00
IUUC-Tru-117782	Takifugu rubripes	56.31	0.00e+00	1923.00
IUUC-Tsy-119177	Tarsius syrichta	84.08	0.00e+00	2263.00
IUUC-Tni-120884	Tetraodon nigroviridis	53.11	0.00e+00	1755.00
IUUC-Tbe-128088	Tupaia belangeri	84.14	0.00e+00	1297.00
IUUC-Ttr-129062	Tursiops truncatus	88.37	0.00e+00	3086.00
IUUC-Vpa-130578	Vicugna pacos	86.87	0.00e+00	3003.00
IUUC-Xtr-132244	Xenopus tropicalis	61.27	0.00e+00	2108.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence