iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068013

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02025786

Gene Name

UBR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000010484.2	ENSMLUT00000010545.2	ENSMLUP00000009612.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.70e-08	34.9	1103	1206
E3 activity/N-recognin/N-domain	1.40e-40	137.4	226	302
E3 activity/N-recognin/UBR-box	2.40e-30	104.9	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiC.......................................ledf........kdgplvlpCgHvfhadClqkw........... 29
           C++C                                       l            +g+++++CgHv+ha C+qk+           
   Q: 1103 CILCqeeqevkiennamvlsacvqkstaltqhrgkpiefsgesL--DplfmdsdlAYGTYTGSCGHVMHAVCWQKYfeavqlsfqqr 1187
           77883333333333333333333333333333333333333331..022333333558999************************** PP
   S: 30   ..pglknssskefrCPlCr 46
             ++l +++s+e +CPlC+
   Q: 1188 ihVDLFDLESGEYLCPLCK 1206
           ******************7 PP

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG++a+c+eak++i+++se+++q+pL+Vev
   Q: 226  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAFAACQEAKEDIKSHSENVSQHPLHVEV 302
           9**************************************************************************97 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C +++
   Q: 97   QLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCISHE 167
           68*****************************************************************9986 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MADEEARGVE RMEVGPDLPQ TPQGLASWWD QQVDFHTTFL HHLAQLVPEI YFAEMDPDLE 60
KQEESIQTSI FTPLEWYLFG EDPDICLEKL KHSGVFQLCG KVFKSGETTY SCRDCAIDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG AGGAGGCCAG GGGTGTGGAG AGGATGGAAG TCGGCCCGGA CTTGCCCCAG 60
ACCCCGCAGG GACTGGCATC TGTAAGTCCT CGTGGGCCAG TGCCTTTTGT ACCCCCCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001354	Ailuropoda melanoleuca	91.79	0.00e+00	3236.00
IUUC-Apl-004160	Anas platyrhynchos	76.23	0.00e+00	2679.00
IUUC-Aca-004982	Anolis carolinensis	72.76	0.00e+00	2567.00
IUUC-Ago-007752	Ashbya gossypii	27.22	1.00e-22	103.00
IUUC-Acl-008055	Aspergillus clavatus	24.84	6.00e-37	150.00
IUUC-Ate-010550	Aspergillus terreus	23.07	2.00e-45	179.00
IUUC-Ame-011231	Astyanax mexicanus	55.33	0.00e+00	1821.00
IUUC-Bgr-011999	Blumeria graminis	23.49	9.00e-45	176.00
IUUC-Bta-012347	Bos taurus	91.63	0.00e+00	3205.00
IUUC-Bci-013834	Botrytis cinerea	24.57	5.00e-34	141.00
IUUC-Cja-018911	Callithrix jacchus	86.97	0.00e+00	3052.00
IUUC-Cfa-020991	Canis familiaris	93.11	0.00e+00	3279.00
IUUC-Cpo-021448	Cavia porcellus	89.03	0.00e+00	3135.00
IUUC-Cre-022930	Chlamydomonas reinhardtii	42.31	3.30e-02	30.40
IUUC-Csa-024255	Chlorocebus sabaeus	91.55	0.00e+00	2678.00
IUUC-Cho-024550	Choloepus hoffmanni	76.32	0.00e+00	1956.00
IUUC-Csv-026296	Ciona savignyi	29.13	2.00e-20	93.60
IUUC-Dno-029427	Dasypus novemcinctus	89.71	0.00e+00	3076.00
IUUC-Dor-031073	Dipodomys ordii	76.38	0.00e+00	1328.00
IUUC-Dme-031910	Drosophila melanogaster	31.79	0.00e+00	714.00
IUUC-Ete-032318	Echinops telfairi	71.66	0.00e+00	1188.00
IUUC-Eca-033348	Equus caballus	92.11	0.00e+00	3003.00
IUUC-Eeu-034664	Erinaceus europaeus	82.58	0.00e+00	2861.00
IUUC-Fca-035604	Felis catus	86.43	0.00e+00	2947.00
IUUC-Fal-037333	Ficedula albicollis	76.14	0.00e+00	2640.00
IUUC-Fox-037984	Fusarium oxysporum	25.54	1.00e-37	153.00
IUUC-Gmo-039363	Gadus morhua	54.38	0.00e+00	1599.00
IUUC-Gga-040486	Gallus gallus	75.22	0.00e+00	2595.00
IUUC-Gac-041985	Gasterosteus aculeatus	55.14	0.00e+00	1667.00
IUUC-Ggo-044704	Gorilla gorilla	84.70	0.00e+00	2498.00
IUUC-Hsa-046753	Homo sapiens	91.68	0.00e+00	3248.00
IUUC-Itr-048410	Ictidomys tridecemlineatus	91.13	0.00e+00	3203.00
IUUC-Lch-049904	Latimeria chalumnae	60.49	0.00e+00	2068.00
IUUC-Loc-052624	Lepisosteus oculatus	58.72	0.00e+00	1969.00
IUUC-Laf-053857	Loxodonta africana	87.94	0.00e+00	3083.00
IUUC-Mcc-054873	Macaca mulatta	91.79	0.00e+00	3208.00
IUUC-Meu-056858	Macropus eugenii	62.84	0.00e+00	974.00
IUUC-Mga-059917	Meleagris gallopavo	75.36	0.00e+00	2707.00
IUUC-Mmr-061128	Microcebus murinus	88.09	0.00e+00	3055.00
IUUC-Mdo-062306	Monodelphis domestica	78.19	0.00e+00	2754.00
IUUC-Mmu-063389	Mus musculus	88.06	0.00e+00	3147.00
IUUC-Mpu-065983	Mustela putorius furo	92.31	0.00e+00	3281.00
IUUC-Nle-070031	Nomascus leucogenys	91.79	0.00e+00	3255.00
IUUC-Opr-070551	Ochotona princeps	67.32	0.00e+00	1306.00
IUUC-Ont-072035	Oreochromis niloticus	56.38	0.00e+00	1902.00
IUUC-Ocu-074930	Oryctolagus cuniculus	86.40	0.00e+00	3023.00
IUUC-Oin-079343	Oryza indica	37.50	2.00e-13	72.40
IUUC-Osa-086106	Oryza sativa	42.00	6.00e-13	69.70
IUUC-Ola-086683	Oryzias latipes	55.65	0.00e+00	1838.00
IUUC-Oga-088017	Otolemur garnettii	86.33	0.00e+00	3039.00
IUUC-Oar-089557	Ovis aries	91.10	0.00e+00	3198.00
IUUC-Ptr-091366	Pan troglodytes	90.48	0.00e+00	3223.00
IUUC-Pan-092184	Papio anubis	91.79	0.00e+00	3207.00
IUUC-Psi-093720	Pelodiscus sinensis	77.05	0.00e+00	2641.00
IUUC-Pfo-097124	Poecilia formosa	56.02	0.00e+00	1863.00
IUUC-Pab-098586	Pongo abelii	91.68	0.00e+00	3247.00
IUUC-Pop-099184	Populus trichocarpa	44.21	4.00e-13	69.30
IUUC-Pca-100673	Procavia capensis	80.63	0.00e+00	1646.00
IUUC-Pva-102724	Pteropus vampyrus	87.07	0.00e+00	3030.00
IUUC-Pte-104174	Pyrenophora teres	23.55	1.00e-46	183.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	23.44	2.00e-45	179.00
IUUC-Rno-105474	Rattus norvegicus	86.93	0.00e+00	2296.00
IUUC-Sha-106993	Sarcophilus harrisii	78.36	0.00e+00	2831.00
IUUC-Sar-113447	Sorex araneus	85.61	0.00e+00	2098.00
IUUC-Ssc-115768	Sus scrofa	88.11	0.00e+00	2878.00
IUUC-Tgu-116949	Taeniopygia guttata	70.96	0.00e+00	2417.00
IUUC-Tru-117782	Takifugu rubripes	55.56	0.00e+00	1862.00
IUUC-Tsy-119177	Tarsius syrichta	81.93	0.00e+00	2212.00
IUUC-Tni-120884	Tetraodon nigroviridis	52.17	0.00e+00	1696.00
IUUC-Tre-122137	Trichoderma reesei	25.03	2.00e-57	219.00
IUUC-Tbe-128088	Tupaia belangeri	81.56	0.00e+00	1261.00
IUUC-Ttr-129062	Tursiops truncatus	86.22	0.00e+00	2998.00
IUUC-Vpa-130578	Vicugna pacos	84.16	0.00e+00	2898.00
IUUC-Vvi-130900	Vitis vinifera	44.79	1.00e-12	67.40
IUUC-Xtr-132244	Xenopus tropicalis	59.55	0.00e+00	2042.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence