iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000012331.3	ENSOCUT00000023658.2	ENSOCUP00000019848.2
ENSOCUG00000012331.3	ENSOCUT00000012349.3	ENSOCUP00000010631.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.10e-08	34.6	1114	1219
E3 activity/N-recognin/N-domain	1.40e-40	137.3	227	303
E3 activity/N-recognin/UBR-box	1.60e-31	108.6	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf............kd...................................gplvlpCgHvfhadClqkw........... 29
           C++C+e+              +                                   g+++++CgHv+ha C+qk+           
   Q: 1114 CILCQEEQevkiennamvfsACvqkstaltqhrgkprelsvvpetldplfmdpdlayGTYTGSCGHVMHAVCWQKYfeavqlssqqr 1200
           7788554433333333332200222333333333333333333333333333333337999************************** PP
   S: 30   ..pglknssskefrCPlCr 46
             ++l +++s+e +CPlC+
   Q: 1201 ihVDLFDLESGEYLCPLCK 1219
           ******************7 PP

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG+ya+c+eak++i+++se+++q+pL+Vev
   Q: 227  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEV 303
           9**************************************************************************97 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C +++
   Q: 97   QLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCLNHE 167
           68******************************************************************996 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MADEEAGGAE RMEVSPELPQ TPQRLACWWD QQIDFHHAFL QHLAQLVPEI YFAEMDPDLE 60
KQEESVQMSI FTPLEWYLFG EDPDICLEKL KHSGAFQLCG KVFKSGETTY SCRDCAIDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG AAGAGGCTGG GGGTGCGGAG AGGATGGAAG TCAGCCCCGA GTTGCCCCAG 60
ACCCCTCAGC GACTGGCATG TGTAAGTGCC TGTAGACAAG TTCCTTTTGT CCTCCCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001354	Ailuropoda melanoleuca	90.28	0.00e+00	3173.00
IUUC-Apl-004160	Anas platyrhynchos	75.56	0.00e+00	2599.00
IUUC-Aca-004982	Anolis carolinensis	72.08	0.00e+00	2523.00
IUUC-Ago-007752	Ashbya gossypii	27.04	2.00e-20	95.50
IUUC-Acl-008055	Aspergillus clavatus	22.72	5.00e-42	167.00
IUUC-Ate-010550	Aspergillus terreus	22.70	4.00e-43	171.00
IUUC-Ame-011231	Astyanax mexicanus	55.44	0.00e+00	1806.00
IUUC-Bgr-011999	Blumeria graminis	22.98	8.00e-44	173.00
IUUC-Bta-012347	Bos taurus	89.18	0.00e+00	3108.00
IUUC-Cja-018911	Callithrix jacchus	88.57	0.00e+00	3066.00
IUUC-Cfa-020991	Canis familiaris	90.39	0.00e+00	3172.00
IUUC-Cpo-021448	Cavia porcellus	87.84	0.00e+00	3079.00
IUUC-Cre-022930	Chlamydomonas reinhardtii	46.15	2.20e-02	30.80
IUUC-Csa-024255	Chlorocebus sabaeus	91.32	0.00e+00	2628.00
IUUC-Cho-024550	Choloepus hoffmanni	69.11	0.00e+00	2291.00
IUUC-Dno-029427	Dasypus novemcinctus	88.77	0.00e+00	3023.00
IUUC-Dor-031073	Dipodomys ordii	81.17	0.00e+00	1305.00
IUUC-Ete-032318	Echinops telfairi	74.94	0.00e+00	1248.00
IUUC-Eca-033348	Equus caballus	89.29	0.00e+00	2887.00
IUUC-Eeu-034664	Erinaceus europaeus	80.26	0.00e+00	2787.00
IUUC-Fca-035604	Felis catus	88.45	0.00e+00	1501.00
IUUC-Fal-037333	Ficedula albicollis	75.00	0.00e+00	2552.00
IUUC-Gmo-039363	Gadus morhua	53.36	0.00e+00	1559.00
IUUC-Gga-040486	Gallus gallus	74.15	0.00e+00	2503.00
IUUC-Gac-041985	Gasterosteus aculeatus	54.34	0.00e+00	1647.00
IUUC-Ggo-044704	Gorilla gorilla	84.05	0.00e+00	2429.00
IUUC-Hsa-046753	Homo sapiens	90.26	0.00e+00	3154.00
IUUC-Itr-048410	Ictidomys tridecemlineatus	90.25	0.00e+00	3131.00
IUUC-Lch-049904	Latimeria chalumnae	60.72	0.00e+00	2086.00
IUUC-Loc-052624	Lepisosteus oculatus	59.28	0.00e+00	1969.00
IUUC-Laf-053857	Loxodonta africana	89.25	0.00e+00	3120.00
IUUC-Mcc-054873	Macaca mulatta	90.54	0.00e+00	3139.00
IUUC-Meu-056858	Macropus eugenii	65.43	0.00e+00	1020.00
IUUC-Mga-059917	Meleagris gallopavo	74.31	0.00e+00	2613.00
IUUC-Mmr-061128	Microcebus murinus	86.78	0.00e+00	2961.00
IUUC-Mdo-062306	Monodelphis domestica	77.21	0.00e+00	2675.00
IUUC-Mmu-063389	Mus musculus	87.09	0.00e+00	3079.00
IUUC-Mpu-065983	Mustela putorius furo	90.32	0.00e+00	3169.00
IUUC-Mlu-068013	Myotis lucifugus	86.40	0.00e+00	3028.00
IUUC-Nle-070031	Nomascus leucogenys	90.37	0.00e+00	3160.00
IUUC-Opr-070551	Ochotona princeps	71.43	0.00e+00	1386.00
IUUC-Ont-072035	Oreochromis niloticus	55.53	0.00e+00	1876.00
IUUC-Oba-075295	Oryza barthii	38.54	5.00e-14	74.70
IUUC-Ogl-077571	Oryza glaberrima	36.21	5.00e-20	94.70
IUUC-Ogu-078497	Oryza glumaepatula	38.54	4.00e-14	74.70
IUUC-Oin-079343	Oryza indica	38.54	5.00e-14	74.30
IUUC-Oni-083099	Oryza nivara	38.54	5.00e-14	74.70
IUUC-Oru-084471	Oryza rufipogon	38.54	5.00e-14	74.70
IUUC-Osa-086106	Oryza sativa	42.00	3.00e-13	70.50
IUUC-Ola-086683	Oryzias latipes	54.87	0.00e+00	1820.00
IUUC-Oga-088017	Otolemur garnettii	85.15	0.00e+00	2951.00
IUUC-Oar-089557	Ovis aries	88.80	0.00e+00	3112.00
IUUC-Ptr-091366	Pan troglodytes	89.13	0.00e+00	3130.00
IUUC-Pan-092184	Papio anubis	90.48	0.00e+00	3139.00
IUUC-Psi-093720	Pelodiscus sinensis	76.00	0.00e+00	2567.00
IUUC-Pma-094152	Petromyzon marinus	38.11	3.00e-139	489.00
IUUC-Pfo-097124	Poecilia formosa	54.77	0.00e+00	1830.00
IUUC-Pab-098586	Pongo abelii	90.54	0.00e+00	3165.00
IUUC-Pop-099184	Populus trichocarpa	44.21	2.00e-13	70.50
IUUC-Pca-100673	Procavia capensis	81.94	0.00e+00	1679.00
IUUC-Pva-102724	Pteropus vampyrus	91.97	0.00e+00	2295.00
IUUC-Pte-104174	Pyrenophora teres	23.42	2.00e-44	175.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	23.17	5.00e-44	174.00
IUUC-Rno-105474	Rattus norvegicus	82.50	0.00e+00	2162.00
IUUC-Sha-106993	Sarcophilus harrisii	77.25	0.00e+00	2753.00
IUUC-Sar-113447	Sorex araneus	85.92	0.00e+00	2097.00
IUUC-Ssc-115768	Sus scrofa	84.98	0.00e+00	2763.00
IUUC-Tgu-116949	Taeniopygia guttata	72.53	0.00e+00	2441.00
IUUC-Tru-117782	Takifugu rubripes	55.04	0.00e+00	1861.00
IUUC-Tsy-119177	Tarsius syrichta	77.39	0.00e+00	2041.00
IUUC-Tni-120884	Tetraodon nigroviridis	50.97	0.00e+00	1667.00
IUUC-Tbe-128088	Tupaia belangeri	77.04	0.00e+00	1157.00
IUUC-Ttr-129062	Tursiops truncatus	84.42	0.00e+00	2914.00
IUUC-Uma-129344	Ustilago maydis	23.00	4.00e-54	207.00
IUUC-Vpa-130578	Vicugna pacos	84.53	0.00e+00	1664.00
IUUC-Xtr-132244	Xenopus tropicalis	60.21	0.00e+00	2077.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence