iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064201

Ensembl Protein ID

ENSMUSP00000103056.1

UniProt Accession

Q64321; Q80VV5; ZBT7B_MOUSE

Genbank Protein ID

AAH46533.1; AAA61956.1; CAA85307.1

Protein Name

Zinc finger and BTB domain-containing protein 7B; Krueppel-related zinc finger protein cKrox; T-helper-inducing POZ/Krueppel-like factor; Zinc finger protein 67; Zinc finger protein Th-POK

Genbank Nucleotide ID

BC046533; L35307; Z36549

Gene Name

Zbtb7b; Thpok; Zfp67

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000028042.15	ENSMUST00000107433.7	ENSMUSP00000103056.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	JASPAR	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.20e-09	39.5	34	112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees..............ksklmveikdvqpevfrallkFlYtgkld 66
           +D ++  +g e+++h++vLaa+S++F++lf+ +   +                 +  e++ v pe++ all+F Yt +l+
   Q: 34   CDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGTvmgtggggtasggaG-AGVCELDFVGPEALGALLEFAYTATLT 112
           89****************************77776557899*******9854.88888888***************9986 PP

Organism

Mus musculus

Functional Description
(View)

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.

Protein Sequence
(Fasta)

MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK 60
KLFTEGGGGT VMGTGGGGTA SGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGATCCCG GGTCAGCCCG GGTGAGGGCC AGGGCCCCCC TGGCACCGCC CATTGTGGTC 60
CAACAGGTTG AGCTGGTGTC CTGCGGAGCC ACCTGCTGGA AAGGGAAGGA GGCCCCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0042803--F:protein homodimerization activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0010628--P:positive regulation of gene expression
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043370--P:regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043376--P:regulation of CD8-positive, alpha-beta T cell differentiation

KEGG

mmu:22724

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005247	Anolis carolinensis	56.19	7.00e-50	191.00
IUUC-Ame-010706	Astyanax mexicanus	85.25	2.00e-61	229.00
IUUC-Bta-013174	Bos taurus	87.32	0.00e+00	736.00
IUUC-Cja-019527	Callithrix jacchus	90.07	0.00e+00	731.00
IUUC-Cfa-021183	Canis familiaris	89.91	0.00e+00	783.00
IUUC-Cpo-021564	Cavia porcellus	91.19	0.00e+00	751.00
IUUC-Csa-024245	Chlorocebus sabaeus	90.62	0.00e+00	733.00
IUUC-Dre-028292	Danio rerio	84.17	1.00e-60	227.00
IUUC-Dno-028864	Dasypus novemcinctus	88.60	0.00e+00	704.00
IUUC-Dor-031131	Dipodomys ordii	88.81	0.00e+00	744.00
IUUC-Eca-033561	Equus caballus	80.00	0.00e+00	649.00
IUUC-Eeu-035040	Erinaceus europaeus	75.34	3.00e-92	331.00
IUUC-Fal-036849	Ficedula albicollis	79.61	1.00e-90	326.00
IUUC-Gmo-038776	Gadus morhua	81.30	1.00e-58	219.00
IUUC-Gga-040853	Gallus gallus	89.04	8.00e-77	280.00
IUUC-Gac-041877	Gasterosteus aculeatus	83.46	2.00e-63	236.00
IUUC-Ggo-044434	Gorilla gorilla	90.44	0.00e+00	726.00
IUUC-Hsa-046812	Homo sapiens	90.44	0.00e+00	724.00
IUUC-Itr-048180	Ictidomys tridecemlineatus	90.99	0.00e+00	770.00
IUUC-Lch-049665	Latimeria chalumnae	52.82	4.00e-120	424.00
IUUC-Mcc-055723	Macaca mulatta	90.62	0.00e+00	712.00
IUUC-Meu-056152	Macropus eugenii	77.32	8.00e-137	479.00
IUUC-Mmr-061549	Microcebus murinus	91.54	0.00e+00	800.00
IUUC-Mdo-061946	Monodelphis domestica	78.49	0.00e+00	679.00
IUUC-Mpu-066752	Mustela putorius furo	84.59	0.00e+00	751.00
IUUC-Nle-069749	Nomascus leucogenys	90.62	0.00e+00	732.00
IUUC-Ocu-074243	Oryctolagus cuniculus	87.90	3.00e-116	411.00
IUUC-Ola-087497	Oryzias latipes	70.30	2.00e-64	239.00
IUUC-Oga-088753	Otolemur garnettii	88.69	0.00e+00	757.00
IUUC-Ptr-091391	Pan troglodytes	90.44	0.00e+00	724.00
IUUC-Pan-092553	Papio anubis	90.26	0.00e+00	728.00
IUUC-Pfo-096585	Poecilia formosa	82.68	4.00e-63	236.00
IUUC-Pab-097962	Pongo abelii	90.62	0.00e+00	730.00
IUUC-Pva-102850	Pteropus vampyrus	84.77	0.00e+00	642.00
IUUC-Rno-105216	Rattus norvegicus	97.43	0.00e+00	789.00
IUUC-Sha-107232	Sarcophilus harrisii	78.90	0.00e+00	684.00
IUUC-Ssc-116341	Sus scrofa	87.64	3.00e-92	331.00
IUUC-Tni-120444	Tetraodon nigroviridis	84.25	1.00e-63	237.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence