iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000161011.19	ENST00000389805.8	ENSP00000374455.4
ENSG00000161011.19	ENST00000453046.5	ENSP00000405061.1
ENSG00000161011.19	ENST00000504627.1	ENSP00000425957.1
ENSG00000161011.19	ENST00000510187.5	ENSP00000424477.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15340068; 15493999; 15765181; 15911346; 15964033; 16691492; 16877352; 17052185; 17181397; 17229006; 17296612; 17685470; 23117207; 24642144
ULD/UDP/UFD/PB1	PB1	16949360

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.0011	20.7	396	430
ULD/UDP/UFD/PB1	7.80e-18	66.1	22	102

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGF.dreealqaLraa.nnnleaAvey 37
           + l q+ +MGF d+  +l+ L+++ n+++ aA++ 
   Q: 396  ESLSQMLSMGFsDEGGWLTRLLQTkNYDIGAALDT 430
           6799*******6666*****************985 PP

ULD/UDP/UFD/PB1

   S: 3    rvkvsykgeirsfaldlekpgkfedLlkavrt.ltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqkk 84
           r+ +++++e+++ a+++++pg +e+Ll++v++ +++l+   ++ +Y+DedGDlv+++sDe+l++a+s+   k++++r++i++k
   Q: 22   RFSFCCSPEPEAEAEAAAGPGPCERLLSRVAAlFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSY--VKDDIFRIYIKEK 102
           899*****************************999********************************7..9*********975 PP

Organism

Homo sapiens

Functional Description
(View)

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

Protein Sequence
(Fasta)

MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP 60
GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGCCGCCT TCCGCGGCCA CCGCCGGGCC CGCTCCCGCC GCCGACGCCC AGGTGCGCCA 60
GGTGCGGGCC GGGCGGGGGT CGCGCTCACC TTTCTGGCCG CTGAGTGCCG CGTACCAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0036--Amyotrophic lateral sclerosis
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000270--PB1_dom
IPR033741--SQSTM_UBA
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS51745--PB1
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF00564--PB1
PF16577--UBA_5
PF00569--ZZ

SMART

SM00666--PB1
SM00165--UBA
SM00291--ZnF_ZZ

Gene Ontology

GO:0016235--C:aggresome
GO:0044753--C:amphisome
GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0016234--C:inclusion body
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0016605--C:PML body
GO:0000407--C:pre-autophagosomal structure
GO:0097225--C:sperm midpiece
GO:0042802--F:identical protein binding
GO:0019901--F:protein kinase binding
GO:0005080--F:protein kinase C binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0030971--F:receptor tyrosine kinase binding
GO:0042169--F:SH2 domain binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0006914--P:autophagy
GO:0030154--P:cell differentiation
GO:0016197--P:endosomal transport
GO:0002376--P:immune system process
GO:0035556--P:intracellular signal transduction
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0043066--P:negative regulation of apoptotic process
GO:0044130--P:negative regulation of growth of symbiont in host
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0043065--P:positive regulation of apoptotic process
GO:0016239--P:positive regulation of macroautophagy
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:0001934--P:positive regulation of protein phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0051291--P:protein heterooligomerization
GO:0008104--P:protein localization
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010821--P:regulation of mitochondrion organization
GO:0061635--P:regulation of protein complex stability
GO:0046578--P:regulation of Ras protein signal transduction
GO:0006950--P:response to stress
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:8878

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001367	Ailuropoda melanoleuca	90.86	1.00e-169	588.00
IUUC-Apl-003897	Anas platyrhynchos	59.06	5.00e-116	410.00
IUUC-Aca-004699	Anolis carolinensis	47.81	1.00e-94	340.00
IUUC-Ame-010982	Astyanax mexicanus	45.37	1.00e-65	243.00
IUUC-Bta-012634	Bos taurus	92.05	0.00e+00	750.00
IUUC-Cel-018660	Caenorhabditis elegans	50.00	1.00e-10	59.70
IUUC-Cja-019684	Callithrix jacchus	94.55	0.00e+00	754.00
IUUC-Cfa-020573	Canis familiaris	84.66	3.00e-136	478.00
IUUC-Cpo-021425	Cavia porcellus	79.50	8.00e-175	606.00
IUUC-Csa-023968	Chlorocebus sabaeus	96.59	0.00e+00	750.00
IUUC-Cho-024596	Choloepus hoffmanni	85.81	2.00e-51	196.00
IUUC-Cin-025557	Ciona intestinalis	34.15	2.00e-12	67.00
IUUC-Csv-025974	Ciona savignyi	25.77	7.00e-13	68.20
IUUC-Dre-028621	Danio rerio	43.91	4.00e-95	341.00
IUUC-Dno-029060	Dasypus novemcinctus	88.51	0.00e+00	727.00
IUUC-Dor-030547	Dipodomys ordii	89.38	3.00e-135	475.00
IUUC-Ete-033201	Echinops telfairi	79.36	9.00e-163	566.00
IUUC-Eca-033456	Equus caballus	90.86	0.00e+00	676.00
IUUC-Eeu-035157	Erinaceus europaeus	81.28	1.00e-170	592.00
IUUC-Fca-035403	Felis catus	90.54	0.00e+00	703.00
IUUC-Fal-036798	Ficedula albicollis	57.14	9.00e-134	470.00
IUUC-Gmo-039619	Gadus morhua	40.96	2.00e-47	182.00
IUUC-Gga-040137	Gallus gallus	57.78	7.00e-133	467.00
IUUC-Gac-042410	Gasterosteus aculeatus	45.39	3.00e-95	342.00
IUUC-Ggo-044690	Gorilla gorilla	99.32	0.00e+00	764.00
IUUC-Itr-048536	Ictidomys tridecemlineatus	93.41	0.00e+00	773.00
IUUC-Lch-049658	Latimeria chalumnae	47.29	5.00e-110	391.00
IUUC-Loc-052589	Lepisosteus oculatus	47.70	2.00e-109	389.00
IUUC-Laf-053746	Loxodonta africana	82.29	0.00e+00	644.00
IUUC-Mcc-055635	Macaca mulatta	95.68	0.00e+00	765.00
IUUC-Meu-056528	Macropus eugenii	51.00	2.00e-100	358.00
IUUC-Mga-059458	Meleagris gallopavo	59.65	1.00e-118	419.00
IUUC-Mvi-060347	Microbotryum violaceum	54.05	2.00e-07	52.40
IUUC-Mmr-061539	Microcebus murinus	90.85	8.00e-140	489.00
IUUC-Mdo-063083	Monodelphis domestica	64.98	8.00e-150	523.00
IUUC-Mmu-063589	Mus musculus	89.14	0.00e+00	741.00
IUUC-Mpu-065727	Mustela putorius furo	89.22	8.00e-180	622.00
IUUC-Mlu-067026	Myotis lucifugus	88.00	0.00e+00	630.00
IUUC-Nle-069356	Nomascus leucogenys	68.83	6.00e-129	454.00
IUUC-Opr-071091	Ochotona princeps	71.00	2.00e-94	339.00
IUUC-Ont-071864	Oreochromis niloticus	46.97	1.00e-101	363.00
IUUC-Oan-073308	Ornithorhynchus anatinus	64.52	3.00e-136	478.00
IUUC-Ocu-074110	Oryctolagus cuniculus	92.05	0.00e+00	735.00
IUUC-Ola-086944	Oryzias latipes	45.25	2.00e-40	158.00
IUUC-Oga-088869	Otolemur garnettii	91.93	0.00e+00	744.00
IUUC-Oar-089857	Ovis aries	93.07	0.00e+00	659.00
IUUC-Ptr-091640	Pan troglodytes	99.77	0.00e+00	766.00
IUUC-Pan-092831	Papio anubis	96.64	0.00e+00	755.00
IUUC-Psi-093925	Pelodiscus sinensis	56.32	4.00e-125	441.00
IUUC-Pma-094576	Petromyzon marinus	30.95	9.00e-30	124.00
IUUC-Pfo-097297	Poecilia formosa	43.68	1.00e-89	323.00
IUUC-Pab-098725	Pongo abelii	87.05	0.00e+00	665.00
IUUC-Pca-101106	Procavia capensis	91.14	0.00e+00	714.00
IUUC-Pva-102710	Pteropus vampyrus	88.21	0.00e+00	640.00
IUUC-Rno-105539	Rattus norvegicus	89.14	0.00e+00	744.00
IUUC-Sha-107469	Sarcophilus harrisii	61.08	9.00e-122	430.00
IUUC-Ssc-115526	Sus scrofa	92.95	0.00e+00	730.00
IUUC-Tgu-117194	Taeniopygia guttata	60.31	3.00e-117	414.00
IUUC-Tru-117896	Takifugu rubripes	47.87	2.00e-100	359.00
IUUC-Tni-119943	Tetraodon nigroviridis	47.35	2.00e-89	322.00
IUUC-Ttr-128676	Tursiops truncatus	92.27	0.00e+00	752.00
IUUC-Vda-129812	Verticillium dahliae	40.26	6.00e-08	52.80
IUUC-Vpa-130319	Vicugna pacos	96.00	1.00e-56	213.00
IUUC-Xtr-132907	Xenopus tropicalis	53.81	2.00e-126	445.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence