iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000161133.16	ENST00000292729.12	ENSP00000292729.8
ENSG00000161133.16	ENST00000454608.3	ENSP00000414922.3

Annotation

Cancer Mutation
ICGC	COSMIC	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	COSMIC
HPM
DNA & RNA Element
microRNA	TRANSFAC	TargetScan	miRcode
RAID2
Protein-protein Interaction
IID	HINT	InWeb_IM
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-53	184.0	55	349

Active Site

Position(s)	Description	Evidence
64	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
318	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +Gl+N+g tC +NS++Q+ ++  ++++ l++    ++++ + +e+  ++  ++  l+e++++s++kav p el  +l+k+++    + q+Da
   Q: 55   VGLHNIGQTCCLNSLIQVFVMNVDFARILKR---ITVPRGA-DEQRRSVPFQMLLLLEKMQDSRQKAVWPLELAYCLQKYNVP--LFVQHDA 140
           6******************************...5555443.567889*********************************99..79***** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
             +   l + +++++                           + +  + ++ l+ +++k++++cl+c+ +ssr++++l+l l++ + +++ +
   Q: 141  AQLYLKLWNLIKDQI--------------------------ADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPL 206
           ***************..........................567788999**************************************999* PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls.......pfctspe 269
           ++l+d+L+ f+++ el ++ k++ce+c kk++ ++ lkl++lP++L++hL+Rfs ++  ++ +ki  +++fp++Ld s       + c    
   Q: 207  KTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN--SQTRKICHSLYFPQSLDFSqilpmkrESCDA-- 294
           *****************************************************7755..6888***************554322112222.. PP
   S: 270  ekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevle 324
            ++++  +YeL+av+ H G ++sGHY++y++n  +gkW++f+Ds++  v++e+++ 
   Q: 295  -EEQSGGQYELFAVIAHVGMADSGHYCVYIRNaVDGKWFCFNDSNICLVSWEDIQC 349
           .223389*************************55777****************986 PP

Organism

Homo sapiens

Functional Description
(View)

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MDGVLFRAHQ CQYVHPCVHV YVTVGLMDPL CRRKSKSRKQ NKLQPNLRIC PWSLVGLHNI 60
GQTCCLNSLI QVFVMNVDFA RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVWP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGGCG TCTTGTTCAG GTGAATTTGT AGACCTGTGT GTGTGTGTGG TTCTCTCAAA 60
GTTCTAGTTT GTTGTGAGAT GGTATGCACC TCTTTTCATT TGTGGGGCTG TAGACCTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ggo-044957	Gorilla gorilla	97.80	5.00e-160	556.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence