iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000161996.18	ENST00000549091.5	ENSP00000448122.1
ENSG00000161996.18	ENST00000293879.8	ENSP00000293879.4
ENSG00000161996.18	ENST00000552728.5	ENSP00000448603.1
ENSG00000161996.18	ENST00000550739.1	ENSP00000447435.1
ENSG00000161996.18	ENST00000547944.5	ENSP00000449576.1
ENSG00000161996.18	ENST00000315764.8	ENSP00000322808.4
ENSG00000161996.18	ENST00000551100.1	ENSP00000450308.1
ENSG00000161996.18	ENST00000546896.1	ENSP00000447915.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
HINT	InWeb_IM
Disease-associated Variation
GWASdb
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-36	123.0	1435	1467
UBD/Beta-Prp	1.30e-79	269.2	1306	1608

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH ++v+ + f ++  + +++s Dg+++vW l 
   Q: 1435 GHRSKVNEVVFsPGeSHCATCSEDGSVRVWALA 1467
           8***********8889**************875 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvw...dls..........tgkcvhtlk. 91
           +++    +ll  g  +g + vwd++ g ++ s + +++++  + fs +   lv+gs+ + +++w    +s          +++ ++  + 
   Q: 1306 LCY-GAPPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGS--RLVSGSSTGRLRLWavgAVSelrckgsgarSSSVFMEHEl 1392
           555.344566777778********************************..7*************66633366788876554444444444 PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
             +  v+s sf+ s d  v+G+   t+    + +g+  + + sgh++ vn vv++p ++ ++++s D+ vr+W l++++l+ +++   ++
   Q: 1393 VLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTR-LISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQV-LNQ 1480
           56899999*****99************997778888888.88**************99**************************98.9** PP
   S: 182  svysls......fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn. 264
           s  +l+       ++++++l++g  dg++++++++++ +  +++ h    + v+fs +++ ++sg +Dg + +    +g++ ++l+ h+ 
   Q: 1481 SCLCLAwsppccGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQg 1570
           ******55555555666*********************************************************99*************9 PP
   S: 265  ..ssvisvav.....lsfgdnvlvlgse.dskvniwkl 294
              s i+v++     l++++  l l+++ d++v +w+ 
   Q: 1571 apISTICVTCkecedLGVEGTDLWLAASgDQRVSVWAS 1608
           99999999999999999998888777666*******85 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MARAWQHPFL NVFRHFRVDE WKRSAKQGDV AVVTDKTLKG AVYRIRGSVS AANYIQLPKS 60
STQSLGLTGR YLYVLFRPLP SKHFVIHLDV SSKDNQVIRV SFSNLFKEFK STATWLQFPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGGCGGAA GTGGCACCGT TGCCAGGCAG CCGTTGCCTG GCGTCGCGGG GCGTACTCTG 60
CGCTGGGCGC GCGGAGGCCT AGGCGGGAAG CTCGAGCGGC GGCGCCATGG CCCGAGGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR007714--CFA20/WDR90/C3orf67
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR030466--WDR90

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF05018--DUF667
PF00400--WD40

SMART

SM00320--WD40

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001801	Ailuropoda melanoleuca	70.54	0.00e+00	1372.00
IUUC-Apl-003387	Anas platyrhynchos	52.79	0.00e+00	1631.00
IUUC-Aca-005235	Anolis carolinensis	52.24	0.00e+00	1639.00
IUUC-Ame-011595	Astyanax mexicanus	53.46	0.00e+00	718.00
IUUC-Bta-012328	Bos taurus	68.93	0.00e+00	2278.00
IUUC-Cja-019058	Callithrix jacchus	83.42	0.00e+00	2594.00
IUUC-Cfa-020934	Canis familiaris	65.31	0.00e+00	2040.00
IUUC-Cpo-022025	Cavia porcellus	67.85	0.00e+00	2296.00
IUUC-Cre-022928	Chlamydomonas reinhardtii	29.36	1.00e-60	229.00
IUUC-Csa-023022	Chlorocebus sabaeus	88.75	0.00e+00	3028.00
IUUC-Cin-025133	Ciona intestinalis	36.41	0.00e+00	708.00
IUUC-Csv-025816	Ciona savignyi	36.07	3.00e-169	590.00
IUUC-Dre-028823	Danio rerio	46.35	0.00e+00	1568.00
IUUC-Dno-029211	Dasypus novemcinctus	74.50	0.00e+00	861.00
IUUC-Dor-030211	Dipodomys ordii	71.74	0.00e+00	2058.00
IUUC-Ete-032363	Echinops telfairi	58.96	0.00e+00	879.00
IUUC-Eca-034296	Equus caballus	71.21	0.00e+00	1347.00
IUUC-Eeu-035226	Erinaceus europaeus	60.94	0.00e+00	876.00
IUUC-Fca-035384	Felis catus	69.21	0.00e+00	2319.00
IUUC-Fal-037660	Ficedula albicollis	55.66	0.00e+00	1002.00
IUUC-Gga-040666	Gallus gallus	55.22	0.00e+00	1307.00
IUUC-Gac-041358	Gasterosteus aculeatus	46.21	0.00e+00	1511.00
IUUC-Ggo-045121	Gorilla gorilla	97.94	0.00e+00	3364.00
IUUC-Itr-048485	Ictidomys tridecemlineatus	69.94	0.00e+00	2228.00
IUUC-Lch-050009	Latimeria chalumnae	48.41	0.00e+00	1631.00
IUUC-Loc-052629	Lepisosteus oculatus	45.38	0.00e+00	822.00
IUUC-Mcc-055834	Macaca mulatta	85.93	0.00e+00	2791.00
IUUC-Meu-056162	Macropus eugenii	49.55	0.00e+00	927.00
IUUC-Mga-060167	Meleagris gallopavo	52.19	0.00e+00	1604.00
IUUC-Mmr-060761	Microcebus murinus	82.89	1.00e-149	522.00
IUUC-Mdo-061886	Monodelphis domestica	57.22	0.00e+00	2097.00
IUUC-Mmu-063652	Mus musculus	68.71	0.00e+00	2382.00
IUUC-Mlu-068141	Myotis lucifugus	64.90	0.00e+00	2128.00
IUUC-Nle-069133	Nomascus leucogenys	92.49	0.00e+00	2139.00
IUUC-Ont-072496	Oreochromis niloticus	47.21	0.00e+00	1663.00
IUUC-Oan-072833	Ornithorhynchus anatinus	50.78	0.00e+00	896.00
IUUC-Ola-086564	Oryzias latipes	45.46	0.00e+00	1557.00
IUUC-Oga-088919	Otolemur garnettii	74.26	0.00e+00	2516.00
IUUC-Oar-089946	Ovis aries	72.52	0.00e+00	910.00
IUUC-Ptr-090755	Pan troglodytes	98.30	0.00e+00	2837.00
IUUC-Pan-092054	Papio anubis	87.15	0.00e+00	2994.00
IUUC-Psi-093467	Pelodiscus sinensis	55.22	0.00e+00	1103.00
IUUC-Pma-094573	Petromyzon marinus	42.47	0.00e+00	810.00
IUUC-Pfo-096849	Poecilia formosa	46.06	0.00e+00	1452.00
IUUC-Pab-098320	Pongo abelii	90.97	0.00e+00	2989.00
IUUC-Pca-100172	Procavia capensis	65.91	0.00e+00	2043.00
IUUC-Pva-102772	Pteropus vampyrus	70.60	0.00e+00	1362.00
IUUC-Rno-105046	Rattus norvegicus	68.90	0.00e+00	2395.00
IUUC-Sha-107094	Sarcophilus harrisii	57.36	0.00e+00	2135.00
IUUC-Ssc-116257	Sus scrofa	67.36	0.00e+00	2196.00
IUUC-Tgu-117323	Taeniopygia guttata	59.47	0.00e+00	826.00
IUUC-Tru-118717	Takifugu rubripes	45.11	0.00e+00	1481.00
IUUC-Tni-120108	Tetraodon nigroviridis	45.87	0.00e+00	889.00
IUUC-Ttr-128378	Tursiops truncatus	72.30	0.00e+00	1684.00
IUUC-Xtr-131760	Xenopus tropicalis	49.89	0.00e+00	1692.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence