iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052338

Ensembl Protein ID

ENSLOCP00000007915.1

UniProt Accession

W5MHQ6; W5MHQ6_LEPOC

Genbank Protein ID

ENSLOCP00000007915

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01015961

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000006551.1	ENSLOCT00000007925.1	ENSLOCP00000007915.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.10e-83	278.4	84	806

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..................ellkslqklfeel..... 60
           +Gl+NlgNtCY+NS+LQ+L+ +p +++ +++      k      ++++++++g                  ell+s+++l+ +l     
   Q: 84   VGLNNLGNTCYLNSILQVLYYCPGFKDGIKKlynllsK------KNEKQKDDGakteekqeqseealpvniELLSSFHSLIVSLeqlqs 166
           6******************************5555442......333333333344444566777887888566666666555533333 PP
   S: 61   ..w...kskkk......avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......... 129
             +   +   k      a  pr+ll++l++++++++gy q+DaqE+l+++l  ++e+++   +k++ + e+ +++ ++++         
   Q: 167  syLlnpE---KytdgelAAPPRRLLNTLRQLNPMYEGYLQHDAQEVLQCILGYIQEACET-IKKEYLSHEDPADKPTEMHqkhmaekee 251
           2233330...1444455999**************************************66.4444444444443444333567777788 PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 252  iisstapkvsiretenalkdaknleqdrilegqangkrksdtevgnakkkskthktqkpveenkhftrskrksssdivieshmeevkee 340
           999999*********************************************************************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 341  gndsddkkdnvskgiakkkkrpklnwlkssgkqpsifskfrsmgrrslhsggkeevkppvgngpclalvehedvkddtasdhpvdnllh 429
           ***************************************************************************************98 PP
   S: 130  aeekkkkknk...slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..............slqdcLesftkeeele 201
           +++k+k++++   +l+++lFqgql  +++clec+  ++r+e+f+d+s+pv+++e +k                +l++++++f++ e++ 
   Q: 430  EKQKTKSEGEccfDLMERLFQGQLVLRTRCLECECYTERREDFQDISVPVQEDEPSKVDssteispdpkmelkTLKWAISQFASVERIV 518
           444444444456699***************************************777769***************************** PP
   S: 202  genkyycekckkkqeaekklklkklPevLilhLkRf.....sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvv 285
           ge+ky+ce+c++++eae++l ++k Pev+++hLk+f     +f+ + +  +k+n+ +++pl+L+l+++ct+p+     k+ YeL+avv+
   Q: 519  GEDKYFCETCHHYTEAERSLLFDKTPEVITIHLKCFaanssEFDPYAG-LSKVNTPLQTPLKLSLDEWCTKPS-----KEDYELFAVVM 601
           ************************************888888888855.56********************99.....567******** PP
   S: 286  HsG.slssGHYvayvkn........................................................................ 301
           HsG ++ssGHY++y+k                                                                         
   Q: 602  HSGvTISSGHYTTYIKMmdlknvklqnkvhieedlkpeplneaearacdiqeyddgevsfgksgkghstatgkvstkkssegigllggq 690
           ***************************************************************************************** PP
   S: 302  ..........................................................................ekgkWllfdDskVte 316
                                                                                      +gkW+lfdDs+V+ 
   Q: 691  rsitsfelggnkaansekpicatgnngkmdhgcasgyesaiksekesadanstcnelldakspladsafcnvldYEGKWMLFDDSEVRL 779
           ****************************************99999999999999999999988888888888777999*********** PP
   S: 317  vkeeevleetg......staYvlfYkr 337
           v+e+++l+ ++      st+Y+lfYk+
   Q: 780  VDEKDFLSACSpescttSTPYLLFYKK 806
           ********999**************97 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MPGLVQNEGN GAASGSPLKK NRLSLKFFQK KETKRALNFS EAQEEEEDKP SEPPETESCD 60
QVVPVPNPSS PLTCEKKERL VPFVGLNNLG NTCYLNSILQ VLYYCPGFKD GIKKLYNLLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCTTTGCA GAGGAAAAAC CGCCAAGTTC TGTGCTGGTT GGGATAATAC GAAAACAAAC 60
GAATTTGTTG AATGGATAAA AAAAAACGCT AAGTAATTAA AACCTATTTT CATTCAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001939	Ailuropoda melanoleuca	52.40	0.00e+00	722.00
IUUC-Apl-004204	Anas platyrhynchos	52.39	0.00e+00	669.00
IUUC-Aca-004637	Anolis carolinensis	53.18	0.00e+00	711.00
IUUC-Ame-011718	Astyanax mexicanus	59.57	0.00e+00	795.00
IUUC-Bta-012552	Bos taurus	52.28	0.00e+00	734.00
IUUC-Cja-019588	Callithrix jacchus	53.94	0.00e+00	748.00
IUUC-Cfa-020211	Canis familiaris	53.39	0.00e+00	735.00
IUUC-Cpo-021551	Cavia porcellus	52.95	0.00e+00	719.00
IUUC-Csa-024186	Chlorocebus sabaeus	53.25	0.00e+00	738.00
IUUC-Cho-024739	Choloepus hoffmanni	45.62	5.00e-98	352.00
IUUC-Dre-028184	Danio rerio	57.99	0.00e+00	792.00
IUUC-Dno-029669	Dasypus novemcinctus	52.59	0.00e+00	734.00
IUUC-Dor-030168	Dipodomys ordii	49.76	0.00e+00	634.00
IUUC-Dme-031732	Drosophila melanogaster	30.00	1.00e-17	85.50
IUUC-Ete-032825	Echinops telfairi	49.91	6.00e-131	461.00
IUUC-Eca-033595	Equus caballus	51.76	0.00e+00	674.00
IUUC-Eeu-034877	Erinaceus europaeus	53.43	3.00e-81	296.00
IUUC-Fca-035381	Felis catus	54.86	5.00e-159	554.00
IUUC-Fal-037592	Ficedula albicollis	53.69	0.00e+00	705.00
IUUC-Gmo-039680	Gadus morhua	50.24	0.00e+00	660.00
IUUC-Gga-041196	Gallus gallus	53.56	0.00e+00	739.00
IUUC-Gac-042292	Gasterosteus aculeatus	50.72	0.00e+00	642.00
IUUC-Ggo-044671	Gorilla gorilla	53.20	0.00e+00	745.00
IUUC-Hsa-047020	Homo sapiens	53.49	0.00e+00	744.00
IUUC-Itr-048800	Ictidomys tridecemlineatus	47.69	5.00e-178	617.00
IUUC-Lch-050543	Latimeria chalumnae	52.79	0.00e+00	662.00
IUUC-Laf-053707	Loxodonta africana	52.34	0.00e+00	723.00
IUUC-Mcc-055885	Macaca mulatta	53.56	0.00e+00	743.00
IUUC-Meu-056573	Macropus eugenii	50.62	3.00e-175	608.00
IUUC-Mga-059346	Meleagris gallopavo	53.68	0.00e+00	711.00
IUUC-Mmr-061612	Microcebus murinus	52.81	0.00e+00	731.00
IUUC-Mdo-062887	Monodelphis domestica	52.50	0.00e+00	698.00
IUUC-Mmu-064044	Mus musculus	52.88	0.00e+00	733.00
IUUC-Mpu-066847	Mustela putorius furo	52.33	0.00e+00	735.00
IUUC-Mlu-067684	Myotis lucifugus	52.75	0.00e+00	732.00
IUUC-Nle-070057	Nomascus leucogenys	53.20	0.00e+00	746.00
IUUC-Opr-070463	Ochotona princeps	49.77	6.00e-138	484.00
IUUC-Ont-071975	Oreochromis niloticus	51.48	0.00e+00	657.00
IUUC-Oan-073062	Ornithorhynchus anatinus	66.34	7.00e-32	129.00
IUUC-Ocu-074840	Oryctolagus cuniculus	53.28	0.00e+00	737.00
IUUC-Ola-087088	Oryzias latipes	51.58	0.00e+00	733.00
IUUC-Oga-088472	Otolemur garnettii	53.39	0.00e+00	725.00
IUUC-Oar-089498	Ovis aries	52.81	0.00e+00	736.00
IUUC-Ptr-091395	Pan troglodytes	53.20	0.00e+00	744.00
IUUC-Pan-092462	Papio anubis	53.56	0.00e+00	744.00
IUUC-Psi-093583	Pelodiscus sinensis	53.11	0.00e+00	631.00
IUUC-Pma-094644	Petromyzon marinus	36.84	5.00e-29	120.00
IUUC-Pfo-096314	Poecilia formosa	53.73	0.00e+00	733.00
IUUC-Pab-098568	Pongo abelii	53.20	0.00e+00	746.00
IUUC-Pca-100948	Procavia capensis	49.88	1.00e-98	354.00
IUUC-Pva-102853	Pteropus vampyrus	52.92	0.00e+00	737.00
IUUC-Rno-105573	Rattus norvegicus	52.69	0.00e+00	726.00
IUUC-Sha-107495	Sarcophilus harrisii	51.03	2.00e-165	575.00
IUUC-Sar-113545	Sorex araneus	59.95	2.00e-111	396.00
IUUC-Ssc-115962	Sus scrofa	53.28	0.00e+00	745.00
IUUC-Tgu-116731	Taeniopygia guttata	54.00	0.00e+00	708.00
IUUC-Tru-117893	Takifugu rubripes	54.78	0.00e+00	699.00
IUUC-Tsy-119644	Tarsius syrichta	51.01	8.00e-95	341.00
IUUC-Tni-119819	Tetraodon nigroviridis	50.67	0.00e+00	681.00
IUUC-Tbe-127272	Tupaia belangeri	48.65	3.00e-170	592.00
IUUC-Ttr-128404	Tursiops truncatus	52.76	0.00e+00	739.00
IUUC-Vpa-130205	Vicugna pacos	52.59	0.00e+00	729.00
IUUC-Xtr-132613	Xenopus tropicalis	51.19	0.00e+00	676.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence