iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-17	64.0	439	495

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++++++ly ++a +ddeL+l+kGd+v++  +e+++egW+ g   l+gk+G fP+ +ve+l
   Q: 439  NNQLCKALYTFQARQDDELNLEKGDIVTI--HEKKEEGWWFG--SLNGKKGHFPAAYVEEL 495
           5789*************************..59*********..9**************98 PP

Organism

Rattus norvegicus

Functional Description
(View)

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.

Protein Sequence
(Fasta)

MRDPLTDCSY NKVYKSLKEF AQNGDNFCKQ ITSVLQQRAN LEISYAKGLQ KLAVKLSKAL 60
QSTKKNCLST AWAWASESMK SAADLHQKLG KAIELEAIKP THQVLSMQEK KRKSLDNEVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTGACGTAC TCTAAGCCCT TTGAATCCCG GAAGTCCAGA ACACACCCAA CCTAATTGAT 60
TGCAGCGTCC AGCATGCTGG AGCGTAGGTA AAAGAAAAAG CAGACAACAT TTCAACATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR011072--HR1_rho-bd
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3

PROSITE

PS51741--F_BAR
PS50002--SH3

Pfam

PF00611--FCH
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA

SMART

SM00055--FCH
SM00326--SH3

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005856--C:cytoskeleton
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0006897--P:endocytosis
GO:0045892--P:negative regulation of transcription, DNA-templated

KEGG

rno:311111

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001403	Ailuropoda melanoleuca	73.91	1.00e-106	380.00
IUUC-Aca-005138	Anolis carolinensis	49.61	6.00e-132	464.00
IUUC-Bta-012680	Bos taurus	79.40	0.00e+00	743.00
IUUC-Cja-019985	Callithrix jacchus	82.40	0.00e+00	786.00
IUUC-Cfa-020888	Canis familiaris	73.19	3.00e-106	379.00
IUUC-Cpo-021852	Cavia porcellus	81.87	0.00e+00	733.00
IUUC-Csa-023196	Chlorocebus sabaeus	82.60	0.00e+00	763.00
IUUC-Cin-025272	Ciona intestinalis	26.32	1.00e-33	137.00
IUUC-Dre-027969	Danio rerio	44.13	4.00e-114	404.00
IUUC-Dno-029703	Dasypus novemcinctus	79.19	0.00e+00	710.00
IUUC-Dor-030928	Dipodomys ordii	82.20	0.00e+00	751.00
IUUC-Dme-032164	Drosophila melanogaster	25.06	1.00e-20	95.90
IUUC-Ete-033034	Echinops telfairi	63.53	8.00e-146	510.00
IUUC-Eca-034165	Equus caballus	79.48	0.00e+00	769.00
IUUC-Eeu-034697	Erinaceus europaeus	77.89	0.00e+00	762.00
IUUC-Fca-035811	Felis catus	76.46	0.00e+00	708.00
IUUC-Gac-041751	Gasterosteus aculeatus	44.35	2.00e-115	409.00
IUUC-Hsa-046868	Homo sapiens	72.17	0.00e+00	691.00
IUUC-Itr-049056	Ictidomys tridecemlineatus	84.40	0.00e+00	806.00
IUUC-Lch-050314	Latimeria chalumnae	51.55	1.00e-76	281.00
IUUC-Loc-051803	Lepisosteus oculatus	47.41	8.00e-123	434.00
IUUC-Laf-053672	Loxodonta africana	81.31	0.00e+00	764.00
IUUC-Mcc-054984	Macaca mulatta	74.73	0.00e+00	730.00
IUUC-Mmr-061250	Microcebus murinus	82.04	0.00e+00	789.00
IUUC-Mdo-062278	Monodelphis domestica	72.51	0.00e+00	684.00
IUUC-Mmu-063360	Mus musculus	94.40	0.00e+00	823.00
IUUC-Mpu-065954	Mustela putorius furo	77.82	0.00e+00	703.00
IUUC-Mlu-066993	Myotis lucifugus	76.77	0.00e+00	708.00
IUUC-Nle-069744	Nomascus leucogenys	66.73	6.00e-180	624.00
IUUC-Opr-070442	Ochotona princeps	68.74	0.00e+00	630.00
IUUC-Ont-072001	Oreochromis niloticus	42.49	3.00e-119	422.00
IUUC-Oan-072971	Ornithorhynchus anatinus	68.08	1.00e-171	596.00
IUUC-Ocu-074140	Oryctolagus cuniculus	82.40	0.00e+00	769.00
IUUC-Oba-075752	Oryza barthii	40.98	4.00e-04	41.60
IUUC-Ola-086827	Oryzias latipes	44.71	1.00e-113	403.00
IUUC-Oga-088144	Otolemur garnettii	81.00	0.00e+00	749.00
IUUC-Oar-090280	Ovis aries	79.40	0.00e+00	721.00
IUUC-Ptr-091508	Pan troglodytes	82.40	0.00e+00	748.00
IUUC-Pan-092649	Papio anubis	81.52	0.00e+00	726.00
IUUC-Pfo-097405	Poecilia formosa	43.65	6.00e-109	388.00
IUUC-Pab-097751	Pongo abelii	82.60	0.00e+00	749.00
IUUC-Pca-100878	Procavia capensis	79.24	0.00e+00	746.00
IUUC-Pva-102337	Pteropus vampyrus	77.40	0.00e+00	743.00
IUUC-Sha-106635	Sarcophilus harrisii	61.89	2.00e-151	529.00
IUUC-Ssc-116156	Sus scrofa	77.15	0.00e+00	745.00
IUUC-Tru-118662	Takifugu rubripes	44.06	7.00e-122	430.00
IUUC-Tsy-119337	Tarsius syrichta	78.57	0.00e+00	672.00
IUUC-Tbe-127388	Tupaia belangeri	84.06	0.00e+00	797.00
IUUC-Ttr-128767	Tursiops truncatus	79.40	0.00e+00	714.00
IUUC-Xtr-132443	Xenopus tropicalis	56.50	2.00e-141	496.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence