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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045922
UUCD1 version UUC-HoS-00811
Ensembl Protein ID ENSP00000401878.2
UniProt Accession Q8NFY9; B4DTW6; Q96JI5; KBTB8_HUMAN
Genbank Protein ID BAG62128.1; AAM43839.1; AAI17488.1; BAB47471.1
Protein Name Kelch repeat and BTB domain-containing protein 8; T-cell activation kelch repeat protein
Genbank Nucleotide ID AK096640; AC020655; BC117487; AB058745
Gene Name KBTBD8; KIAA1842; TAKRP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163376.11 ENST00000460576.5 ENSP00000419738.1
ENSG00000163376.11 ENST00000417314.2 ENSP00000401878.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
iRefIndexMentha
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.80e-17 64.0 49 117
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +D++++v+ g+ f++h+ vLaa S++F+++f+++l es+ +++v i +v++e++  +l++ Yt+++ ++e
   Q: 49   TDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTEST-QKEVRIVGVEAESMDLVLNYAYTSRVILTE 117
           6999***9******************************9.*************************98765 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Protein Sequence
(Fasta)
MAASADLSKS SPTPNGIPSS DPASDAMDPF HACSILKQLK TMYDEGQLTD IVVEVDHGKT 60
FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIVGVEAES MDLVLNYAYT SRVILTEANV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045922|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAATGACAT TTCCTTTTTA AATAGCTGGA GTCGGGGCCC CATCGAGAAA TGGCCGCGTC 60
GGCAGGTGGG TCGTGTGGTG GCCAGGGCGG CGTGGAGGGA GGTGAGGGGG AAGGTGGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045922|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0333--Golgi apparatus
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0810--Translation regulation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR028764--KBTBD8
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0005819--C:spindle
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:84541
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001555 Ailuropoda melanoleuca 98.34 0.00e+00 1225.00
IUUC-Apl-004152 Anas platyrhynchos 89.75 0.00e+00 1106.00
IUUC-Aca-005367 Anolis carolinensis 89.74 0.00e+00 1100.00
IUUC-Bta-012910 Bos taurus 98.17 0.00e+00 1222.00
IUUC-Bol-016130 Brassica oleracea 25.70 3.00e-16 80.50
IUUC-Cja-019722 Callithrix jacchus 99.72 0.00e+00 779.00
IUUC-Cfa-020071 Canis familiaris 97.00 0.00e+00 1212.00
IUUC-Cpo-021642 Cavia porcellus 93.85 0.00e+00 1150.00
IUUC-Csa-023578 Chlorocebus sabaeus 99.48 0.00e+00 1187.00
IUUC-Cho-024601 Choloepus hoffmanni 98.67 0.00e+00 801.00
IUUC-Dre-028688 Danio rerio 73.75 0.00e+00 967.00
IUUC-Dno-029176 Dasypus novemcinctus 95.28 0.00e+00 1169.00
IUUC-Dor-030189 Dipodomys ordii 91.65 0.00e+00 1074.00
IUUC-Ete-032523 Echinops telfairi 93.84 0.00e+00 805.00
IUUC-Eca-034064 Equus caballus 97.59 0.00e+00 1003.00
IUUC-Fca-035368 Felis catus 97.50 0.00e+00 1216.00
IUUC-Fal-037559 Ficedula albicollis 88.89 0.00e+00 1123.00
IUUC-Gmo-039491 Gadus morhua 73.40 0.00e+00 915.00
IUUC-Gga-041061 Gallus gallus 89.88 0.00e+00 1111.00
IUUC-Gac-041498 Gasterosteus aculeatus 73.54 0.00e+00 920.00
IUUC-Ggo-045566 Gorilla gorilla 99.83 0.00e+00 1239.00
IUUC-Itr-047903 Ictidomys tridecemlineatus 93.34 0.00e+00 1171.00
IUUC-Lch-049733 Latimeria chalumnae 78.87 0.00e+00 991.00
IUUC-Loc-052890 Lepisosteus oculatus 74.25 0.00e+00 972.00
IUUC-Laf-053776 Loxodonta africana 96.71 2.00e-148 519.00
IUUC-Mmr-060999 Microcebus murinus 91.69 0.00e+00 1122.00
IUUC-Mdo-063061 Monodelphis domestica 90.51 0.00e+00 1038.00
IUUC-Mmu-063655 Mus musculus 97.50 0.00e+00 1211.00
IUUC-Mpu-066789 Mustela putorius furo 98.17 0.00e+00 1223.00
IUUC-Mlu-067917 Myotis lucifugus 96.35 0.00e+00 1153.00
IUUC-Nle-069449 Nomascus leucogenys 99.67 0.00e+00 1240.00
IUUC-Ont-071291 Oreochromis niloticus 74.30 0.00e+00 957.00
IUUC-Oan-073260 Ornithorhynchus anatinus 87.85 0.00e+00 1095.00
IUUC-Ocu-073840 Oryctolagus cuniculus 97.17 0.00e+00 1201.00
IUUC-Ola-086878 Oryzias latipes 73.39 0.00e+00 949.00
IUUC-Oga-087953 Otolemur garnettii 98.67 0.00e+00 1226.00
IUUC-Oar-089418 Ovis aries 98.00 0.00e+00 1219.00
IUUC-Ptr-090765 Pan troglodytes 99.65 0.00e+00 1183.00
IUUC-Pan-091713 Papio anubis 99.17 0.00e+00 1237.00
IUUC-Psi-094050 Pelodiscus sinensis 90.10 0.00e+00 1114.00
IUUC-Pma-094653 Petromyzon marinus 51.56 5.00e-173 601.00
IUUC-Pno-095011 Phaeosphaeria nodorum 25.42 2.00e-07 49.70
IUUC-Pfo-096352 Poecilia formosa 74.26 0.00e+00 954.00
IUUC-Pab-098712 Pongo abelii 99.70 0.00e+00 717.00
IUUC-Pca-100707 Procavia capensis 95.28 2.00e-115 409.00
IUUC-Pva-102231 Pteropus vampyrus 98.92 4.00e-172 597.00
IUUC-Rno-105214 Rattus norvegicus 97.67 0.00e+00 1217.00
IUUC-Sha-106490 Sarcophilus harrisii 89.77 0.00e+00 1041.00
IUUC-Sar-113362 Sorex araneus 97.22 0.00e+00 1164.00
IUUC-Tgu-117035 Taeniopygia guttata 89.44 0.00e+00 1121.00
IUUC-Tru-118510 Takifugu rubripes 72.67 0.00e+00 936.00
IUUC-Tsy-119204 Tarsius syrichta 99.65 0.00e+00 1187.00
IUUC-Tni-120173 Tetraodon nigroviridis 73.23 0.00e+00 942.00
IUUC-Ttr-128377 Tursiops truncatus 92.87 0.00e+00 1088.00
IUUC-Vpa-130133 Vicugna pacos 97.39 3.00e-89 322.00
Created Date 25-Jun-2017

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