iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005142

Ensembl Protein ID

ENSACAP00000015732.3

UniProt Accession

G1KRY6; G1KRY6_ANOCA

Protein Name

Protein kinase C

Gene Name

PRKCI

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000015906.3	ENSACAT00000016048.3	ENSACAP00000015732.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	2.20e-20	72.6	125	206

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           +vrvk++ykg+i  + + +e++++fe L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 125  QVRVKAYYKGDI--MITYFEPSISFEGLCNEVRDMCAFDNeQLFTMKWIDEEGDPCTVSSQLELEEAFRLYElNKDSELLIHVF 206
           69**********..88******************************************************************98 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MVCPRFLHKF QHCEDEGRGG AASRRACVVT QARTLKGRPL RARAPTFRGA AKGGGSLSLS 60
LALFFFRSSG AGPGQAERGE GAMPTQRESH SSSTGSMSHP GLGGGGGGGS GGVGLGLSGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTTCCATTC CTTTTTCTCA CTCACTGCCG CTGCAATGGT CCATTCCGAG GAGTGTTGTC 60
TGCCCCCCCC CGGTATATCA GAGAAATGGT TTGTCCCAGA TTCCTTCACA AGTTCCAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045171--C:intercellular bridge
GO:0005622--C:intracellular
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007015--P:actin filament organization
GO:0045216--P:cell-cell junction organization
GO:0032869--P:cellular response to insulin stimulus
GO:0035089--P:establishment of apical/basal cell polarity
GO:0042462--P:eye photoreceptor cell development
GO:0035556--P:intracellular signal transduction
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:2000353--P:positive regulation of endothelial cell apoptotic process
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252--P:positive regulation of glial cell proliferation
GO:0046326--P:positive regulation of glucose import
GO:0010976--P:positive regulation of neuron projection development
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity

KEGG

acs:100567847

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	94.85	0.00e+00	977.00
IUUC-Apl-003711	Anas platyrhynchos	96.10	0.00e+00	1064.00
IUUC-Ame-010977	Astyanax mexicanus	88.66	0.00e+00	969.00
IUUC-Bta-013414	Bos taurus	95.12	0.00e+00	1090.00
IUUC-Bol-015169	Brassica oleracea	34.97	2.00e-50	194.00
IUUC-Cel-018340	Caenorhabditis elegans	56.69	0.00e+00	684.00
IUUC-Cja-019802	Callithrix jacchus	95.20	0.00e+00	1063.00
IUUC-Cfa-021236	Canis familiaris	94.43	0.00e+00	1065.00
IUUC-Cpo-022127	Cavia porcellus	93.30	0.00e+00	1028.00
IUUC-Csa-023332	Chlorocebus sabaeus	95.02	0.00e+00	905.00
IUUC-Cho-025054	Choloepus hoffmanni	97.56	6.00e-63	234.00
IUUC-Cin-025740	Ciona intestinalis	60.41	0.00e+00	687.00
IUUC-Csv-026145	Ciona savignyi	78.02	5.00e-172	597.00
IUUC-Dre-028444	Danio rerio	89.70	0.00e+00	990.00
IUUC-Dno-029228	Dasypus novemcinctus	99.03	0.00e+00	645.00
IUUC-Dme-031630	Drosophila melanogaster	68.86	0.00e+00	780.00
IUUC-Ete-032633	Echinops telfairi	70.41	5.00e-174	603.00
IUUC-Eca-033572	Equus caballus	95.20	0.00e+00	1065.00
IUUC-Eeu-035110	Erinaceus europaeus	94.95	0.00e+00	1089.00
IUUC-Fca-035559	Felis catus	94.77	0.00e+00	1088.00
IUUC-Fal-036953	Ficedula albicollis	96.62	0.00e+00	1072.00
IUUC-Gmo-039334	Gadus morhua	89.14	0.00e+00	1004.00
IUUC-Gga-040223	Gallus gallus	96.34	0.00e+00	1096.00
IUUC-Gac-042113	Gasterosteus aculeatus	89.51	0.00e+00	1011.00
IUUC-Ggo-044520	Gorilla gorilla	88.19	0.00e+00	983.00
IUUC-Hsa-046991	Homo sapiens	94.95	0.00e+00	1089.00
IUUC-Lch-050263	Latimeria chalumnae	90.75	0.00e+00	1032.00
IUUC-Loc-052221	Lepisosteus oculatus	90.56	0.00e+00	999.00
IUUC-Laf-053591	Loxodonta africana	95.12	0.00e+00	1091.00
IUUC-Mcc-055118	Macaca mulatta	94.22	0.00e+00	1072.00
IUUC-Mga-059886	Meleagris gallopavo	96.10	0.00e+00	1065.00
IUUC-Mmr-060926	Microcebus murinus	95.12	0.00e+00	1092.00
IUUC-Mdo-062698	Monodelphis domestica	94.25	0.00e+00	1067.00
IUUC-Mmu-063689	Mus musculus	94.59	0.00e+00	1082.00
IUUC-Mpu-066630	Mustela putorius furo	94.77	0.00e+00	1087.00
IUUC-Mlu-067416	Myotis lucifugus	91.30	0.00e+00	1019.00
IUUC-Nle-069811	Nomascus leucogenys	94.95	0.00e+00	1089.00
IUUC-Opr-070466	Ochotona princeps	83.86	0.00e+00	711.00
IUUC-Ont-072278	Oreochromis niloticus	85.86	0.00e+00	955.00
IUUC-Oan-073651	Ornithorhynchus anatinus	98.62	0.00e+00	743.00
IUUC-Ocu-074383	Oryctolagus cuniculus	94.95	0.00e+00	1088.00
IUUC-Ola-087283	Oryzias latipes	79.40	0.00e+00	781.00
IUUC-Oga-088337	Otolemur garnettii	87.37	0.00e+00	981.00
IUUC-Oar-089954	Ovis aries	95.38	0.00e+00	1072.00
IUUC-Ptr-091673	Pan troglodytes	94.95	0.00e+00	1089.00
IUUC-Pan-092494	Papio anubis	95.12	0.00e+00	1090.00
IUUC-Psi-094044	Pelodiscus sinensis	97.21	0.00e+00	1103.00
IUUC-Pfo-096661	Poecilia formosa	87.02	0.00e+00	962.00
IUUC-Pab-097659	Pongo abelii	94.77	0.00e+00	1086.00
IUUC-Pca-101107	Procavia capensis	94.72	0.00e+00	754.00
IUUC-Rno-105790	Rattus norvegicus	94.95	0.00e+00	1088.00
IUUC-Sha-106895	Sarcophilus harrisii	95.23	0.00e+00	1046.00
IUUC-Sar-113513	Sorex araneus	92.21	6.00e-169	587.00
IUUC-Ssc-115835	Sus scrofa	94.83	0.00e+00	978.00
IUUC-Tgu-116874	Taeniopygia guttata	96.69	0.00e+00	1099.00
IUUC-Tru-117823	Takifugu rubripes	87.63	0.00e+00	976.00
IUUC-Tsy-119154	Tarsius syrichta	95.20	0.00e+00	1065.00
IUUC-Tni-119968	Tetraodon nigroviridis	87.14	0.00e+00	959.00
IUUC-Tbe-127238	Tupaia belangeri	75.56	0.00e+00	714.00
IUUC-Ttr-129208	Tursiops truncatus	94.95	0.00e+00	1088.00
IUUC-Vpa-130363	Vicugna pacos	85.07	0.00e+00	926.00
IUUC-Xtr-132652	Xenopus tropicalis	87.63	0.00e+00	1002.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence